在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DNA-binding protein RFX6 (RFX6), partial

  • 中文名稱:
    人RFX6重組蛋白
  • 貨號:
    CSB-YP812809HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RFX6重組蛋白
  • 貨號:
    CSB-EP812809HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RFX6重組蛋白
  • 貨號:
    CSB-EP812809HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RFX6重組蛋白
  • 貨號:
    CSB-BP812809HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RFX6重組蛋白
  • 貨號:
    CSB-MP812809HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RFX6
  • Uniprot No.:
  • 別名:
    RFX6; RFXDC1; DNA-binding protein RFX6; Regulatory factor X 6; Regulatory factor X domain-containing protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.
  • 基因功能參考文獻:
    1. RFX6 heterozygous protein truncating variants cause reduced penetrance maturity-onset diabetes of the young (MODY). PMID: 29026101
    2. study reports two individuals each with compound heterozygous RFX6 nonsense mutations and an intestinal phenotype consistent with Mitchell-Riley syndrome, but with onset of diabetes in childhood rather than in the first 2 weeks of life PMID: 26264437
    3. association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations. PMID: 26537068
    4. RFX6 controls insulin gene transcription, insulin content, and secretion by regulation of Ca(2+)-channel genes. PMID: 25497100
    5. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus. PMID: 23803082
    6. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. PMID: 24390282
    7. Our results provide further support for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in Eastern Asian populations PMID: 22662242
    8. RFX6 mutation is responsible for neonatal diabetes syndrome. PMID: 21965172
    9. Therefore, RFX6 appears to have a pivotal role in the maintenance of the phenotype of the beta-cells in addition to their development. PMID: 21750414
    10. In early development Rfx6 plays a broad role, being essential for development of most anterior endodermal organs. At later stages however, Rfx6 function is restricted to endocrine cells. PMID: 21215266
    11. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20676098
    12. studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans PMID: 20148032
    13. RFX6 is a winged helix transcription factor expressed almost exclusively in the pancreatic islets. PMID: 18673564

    顯示更多

    收起更多

  • 相關疾病:
    Mitchell-Riley syndrome (MTCHRS)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    RFX family
  • 組織特異性:
    Expressed in pancreas. Expressed in pancreatic beta-cells (insulin-positive cells) and alpha-cells (glucagon-positive cells) (at protein level). Specifically expressed in pancreas, small intestine and colon. Expressed in endocrine cells in the islets.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21478

    OMIM: 612659

    KEGG: hsa:222546

    STRING: 9606.ENSP00000332208

    UniGene: Hs.352276



主站蜘蛛池模板: 日本熟妇中文字幕三级| 亚洲码欧美码一区二区三区| 人妻少妇无码精品视频区| 欧美综合乱图图区乱图图区| 欲香欲色天天天综合和网| 少妇被又大又粗又爽毛片久久黑人| 欧美性猛交xxxx三人| 亚洲国产制服丝袜无码av| 护士奶头又白又大又好摸视频| 又色又爽又黄的美女裸体网站| 成人试看30分钟免费视频| 国产日产亚洲系列最新| 亚洲人成无码网站在线观看| 在线aⅴ亚洲中文字幕| 一区二区亚洲精品国产精华液| 亚洲国产a∨无码中文777| 国产精品国产三级国产剧情| 亚洲熟妇无码乱子av电影| 欧美一区二区三区成人片在线| 少妇精品视频无码专区| 内射小寡妇无码| 婷婷五月综合色视频| 亚洲成av人片在www色猫咪| 国产 日韩 中文字幕 制服| 国产丝袜肉丝视频在线| 加比勒色综合久久| 国产网红主播无码精品| 国产真实乱人偷精品人妻| 人妻少妇久久中文字幕| 最新无码a∨在线观看| 最新国产精品精品视频| 夜色福利院在线观看免费| 久久99精品久久久久婷婷| 色翁荡熄又大又硬又粗又动态图| 欧美写真视频在线观看| 国产片av国语在线观麻豆| 成人午夜免费无码区| 国精产品999一区二区三区有限 | 人妻av中文系列| 内射人妻无码色ab麻豆| 综合自拍亚洲综合图区高清|