在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human DNA/RNA-binding protein KIN17 (KIN)

Recombinant Human DNA/RNA-binding protein KIN17 (KIN)

  • 中文名稱：
    人KIN重組蛋白
  • 貨號：
    CSB-YP012351HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KIN重組蛋白
  • 貨號：
    CSB-EP012351HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KIN重組蛋白
  • 貨號：
    CSB-EP012351HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KIN重組蛋白
  • 貨號：
    CSB-BP012351HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KIN重組蛋白
  • 貨號：
    CSB-MP012351HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KIN
  • Uniprot No.：
  • 別名：
    KIN; BTCD; KIN17DNA/RNA-binding protein KIN17; Binding to curved DNA; KIN; antigenic determinant of recA protein homolog
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-393
  • 氨基酸序列
    MGKSDFLTPK AIANRIKSKG LQKLRWYCQM CQKQCRDENG FKCHCMSESH QRQLLLASEN PQQFMDYFSE EFRNDFLELL RRRFGTKRVH NNIVYNEYIS HREHIHMNAT QWETLTDFTK WLGREGLCKV DETPKGWYIQ YIDRDPETIR RQLELEKKKK QDLDDEEKTA KFIEEQVRRG LEGKEQEVPT FTELSRENDE EKVTFNLSKG ACSSSGATSS KSSTLGPSAL KTIGSSASVK RKESSQSSTQ SKEKKKKKSA LDEIMEIEEE KKRTARTDYW LQPEIIVKII TKKLGEKYHK KKAIVKEVID KYTAVVKMID SGDKLKLDQT HLETVIPAPG KRILVLNGGY RGNEGTLESI NEKTFSATIV IETGPLKGRR VEGIQYEDIS KLA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關產(chǎn)品

靶點詳情

  • 功能：
    Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro.
  • 基因功能參考文獻：
    1. Findings demonstrate that kin17 is closely related to the cell proliferation and invasion of cervical cancer. PMID: 28346239
    2. overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype. PMID: 24755081
    3. Trimethylated at Lys-135 by METTL22 PMID: 23349634
    4. up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development PMID: 21980430
    5. ionizing radiation triggers chromatin complex formation in human cells PMID: 11880372
    6. The overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication. PMID: 12359749
    7. results indicate the presence of functional XPA and XPC proteins is essential for the up-regulation of the KIN17 gene after UVC irradiation; also show that the integrity of global genome repair is required to trigger KIN17 gene expression PMID: 12525703
    8. KIN17 protein may be a component of the DNA replication machinery that participates in the cellular response to unrepaired DSBs, and an impaired KIN17 pathway leads to an increased sensitivity to ionizing radiation. PMID: 12751957
    9. A chromatin-associated protein conserved during evolution and overproduced in certain human tumor cell lines, which is involved in DNA replication. PMID: 12754299
    10. Kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells. PMID: 15831485
    11. C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions. PMID: 16511313
    12. Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain PMID: 17045609
    13. Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix. PMID: 18029424

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    KIN17 family
  • 組織特異性：
    Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6327

    OMIM: 601720

    KEGG: hsa:22944

    STRING: 9606.ENSP00000368881

    UniGene: Hs.397918



主站蜘蛛池模板： 欧亚乱熟女一区二区三区在线| 精品国产av一二三四区| 俄罗斯丰满熟妇hd| 婷婷久久综合九色综合绿巨人| 老司机免费的精品视频| 日本免费高清一本视频| 丁香激情综合久久伊人久久| 国产又色又爽无遮挡免费| 国产无遮挡乱子伦免费精品| 亚洲欧美日韩综合俺去了| 97高清国语自产拍| 老熟妇仑乱一区二区视頻| 在线观看黄a∨免费无毒网站| 国产99视频精品免费视频76| 亚洲国产精品无码久久久不卡| 无码专区一va亚洲v专区在线| 欧美激情精品久久久久久| 亚洲国产午夜精华无码福利| 三级三级久久三级久久| 成人做爰视频www| 一本一道久久综合狠狠老| 国产做无码视频在线观看浪潮| 无码av免费一区二区三区四区| 色无码av在线播放| 在线播放国产一区二区三区 | 大陆熟妇丰满多毛xxxx| 国产69精品久久久久人妻刘玥| 国产精品女人呻吟在线观看| 国产手机在线无码播放视频| 天天拍天天看天天做| 中文字幕人妻a片免费看| 国产精品天干在线观看| 香蕉av777xxx色综合一区| 黑巨人与欧美精品一区| 香蕉久久国产超碰青草| 亚洲老熟女性亚洲| 熟女人妻一区二区三区免费看 | 水蜜桃av导航| 亚洲欧美日韩精品色xxx| 国产精品内射视频免费| 亚洲综合激情另类专区|