在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human DEP domain-containing protein 5 (DEPDC5), partial

Recombinant Human DEP domain-containing protein 5 (DEPDC5), partial

  • 中文名稱：
    Recombinant Human DEP domain-containing protein 5(DEPDC5) ,partial
  • 貨號：
    CSB-YP006728HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human DEP domain-containing protein 5(DEPDC5) ,partial
  • 貨號：
    CSB-EP006728HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human DEP domain-containing protein 5(DEPDC5) ,partial
  • 貨號：
    CSB-EP006728HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human DEP domain-containing protein 5(DEPDC5) ,partial
  • 貨號：
    CSB-BP006728HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human DEP domain-containing protein 5(DEPDC5) ,partial
  • 貨號：
    CSB-MP006728HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    DEP domain containing 5; DEP domain-containing protein 5; DEP.5; DEPD5_HUMAN; DEPDC5; FFEVF; KIAA0645
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
  • 基因功能參考文獻：
    1. the DEPDC5-KO HCC cells could acquire anti-oxidant ability through p62 accumulation and survive under leucine starvation, and that downregulated DEPDC5 expression was an independent predictive factor for patient outcome. PMID: 29311600
    2. Knockout of either TSC1 or DEPDC5 led to enhanced HIV-1 reactivation in both a T-cell and a monocyte cell lines. PMID: 30087333
    3. Our finding suggests that DEPDC5 is not only the most common gene for familial focal epilepsy but also could be a significant gene for sporadic focal epilepsy. Since focal epilepsies account for more than 60% of all epilepsies, the effect of mTORC1 inhibitor on patients with focal epilepsy due to DEPDC5 mutations will be an important future direction of research. PMID: 28170089
    4. This cohort study showed DEPDC5 mutations were present in 8% of individuals with focal epilepsy, including one individual with focal cortical dysplasia. PMID: 27173016
    5. DEPDC5 variants increase fibrosis progression in European subjects with chronic HCV infection. Our findings suggest that DEPDC5 down-regulation may contribute to HCV-related fibrosis by increasing MMP2 synthesis through the beta-catenin pathway PMID: 26517016
    6. This revealed four patients to have two or more tumors that were clonally related, all of which lacked MED12 mutations. DEPDC5 was discovered as a novel tumor suppressor gene playing a role in the progression of uterine leiomyomas. PMID: 25964426
    7. This study found a single DEPDC5 mutation in one of (2.2%) 45 families with genetic temporal lobe epilepsy, a proportion much lower than that reported in other inherited focal epilepsies. PMID: 26216793
    8. Genetic variations in DEPDC5 gene region may influence HCV-associated liver cirrhosis and/or hepatocellular carcinoma. development. PMID: 25551790
    9. The effects of 10 DEPDC5 variants identified in individuals with focal epilepsy and two DEPDC5 variants identified in serous ovarian tumors, on TORC1 signaling and GATOR-1 complex formation. PMID: 25366275
    10. A recurrent mutation in DEPDC5 predisposes to focal epilepsies in the French-Canadian population. PMID: 24283814
    11. An association was made for DEPDC5 with sporadic focal cortical dysplasia and also hemimegalencephaly. PMID: 25599672
    12. Truncating DEPDC5 mutations were found in all four French families with focal cortical dysplasia and focal epilepsy. PMID: 25623524
    13. MICA and DEPDC5 SNPs were found to be strongly associated with HCV-induced HCC. PMID: 25764692
    14. This chapter focuses on DEPDC5, a newly identified gene in autosomal dominant focal epilepsies [review] PMID: 25194487
    15. PAPL, IL10RB and DEPDC5 polymorphisms have an impact on progression of hepatitis B virus-related liver disease. PMID: 25032264
    16. Mutations in DEPDC5 are associated with childhood focal epilepsies. PMID: 24591017
    17. DEPDC5 loss-of-function mutations may represent a part of the broader familial focal epilepsy with variable foci phenotype found in 30 European families with a presentation of autosomal dominant nocturnal frontal lobe epilepsy. PMID: 24814846
    18. DEPDC5 mutations are associated with both lesional and nonlesional epilepsies. PMID: 24585383
    19. Mutations in DEPDC5 cause familial focal epilepsy with variable foci. PMID: 23542697
    20. Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. PMID: 21725309

    顯示更多

    收起更多

  • 相關疾病：
    Epilepsy, familial focal, with variable foci 1 (FFEVF1)
  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, perinuclear region. Lysosome membrane.
  • 蛋白家族：
    IML1 family
  • 組織特異性：
    Expressed in developing and adult brain.
  • 數據庫鏈接：

    HGNC: 18423

    OMIM: 604364

    KEGG: hsa:9681

    STRING: 9606.ENSP00000371546

    UniGene: Hs.435022



主站蜘蛛池模板： 男女啪祼交视频| 一边吃奶一边添p好爽高清视频| 性动态图av无码专区| 18禁黄污吃奶免费看网站| 97夜夜澡人人爽人人喊a| 精品aⅴ一区二区三区| 亚洲精品无码少妇30p| 性无码专区无码| 人妻熟女αⅴ一区二区三区| 538prom精品视频在线播放| 波多野结av在线无码中文| 国产一在线精品一区在线观看| 国产成人无码网站| 青青国产揄拍视频 | 日本无卡码高清免费v| 女人喷潮完整视频| 欧美性猛交xxxx免费视频软件 | 亚洲男人天堂| 波多野吉衣av无码| 国产国拍精品av在线观看| 在线 国产 精品 蜜芽| 欧洲成人午夜精品无码区久久| 日本丰满白嫩大屁股ass| 自拍校园亚洲欧美另类| 亚洲人成线无码7777| 成人爽a毛片免费啪啪| 亚洲a∨国产av综合av| 伊人大杳焦在线| 精品人妻少妇一区二区三区| 蜜桃视频网站| 久久久774这里只有精品17| 蜜桃mv在线播放免费观看视频| 超清av在线播放不卡无码| av无码中文一区二区三区四区| 无码国产精成人午夜视频| 国产精品成人av在线观看| 国产av国片偷人妻麻豆| 内射小寡妇无码| 202丰满熟女妇大| 人妻夜夜爽天天爽三区麻豆av网站| 免费的av网站在线观看国产精品|