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  4. Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1), partial

Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1), partial

  • 中文名稱：
    Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase(ALDH1L1) ,partial
  • 貨號(hào)：
    CSB-YP001569HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase(ALDH1L1) ,partial
  • 貨號(hào)：
    CSB-EP001569HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase(ALDH1L1) ,partial
  • 貨號(hào)：
    CSB-EP001569HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase(ALDH1L1) ,partial
  • 貨號(hào)：
    CSB-BP001569HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase(ALDH1L1) ,partial
  • 貨號(hào)：
    CSB-MP001569HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ALDH1L1
  • Uniprot No.：
  • 別名：
    10 formyltetrahydrofolate dehydrogenase; 10 FTHFDH; 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; AL1L1_HUMAN; Aldehyde dehydrogenase 1 family member L1; Aldehyde dehydrogenase family 1 member L1; aldh1l1; Cytosolic 10-formyltetrahydrofolate dehydrogenase; DKFZp781N0997; EC 1.5.1.6; FDH; formyltetrahydrofolate dehydrogenase; FTHFD; OTTHUMP00000155221; OTTHUMP00000214696; OTTHUMP00000214700; OTTHUMP00000222724
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

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靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Our results suggest that ALDH1L1 may be a biomarker for predicting postoperative clinical outcomes. Moreover, ALDH1L1-rs2276724 and mRNA expression were associated with TP53 expression in HBV-related hepatocellular carcinoma patients PMID: 28714006
    2. ALDH1L1 has a role in response to the combined treatment of gossypol and phenformin in non-small cell lung cancer PMID: 27384481
    3. high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients PMID: 27015121
    4. The three functional domains of ALDH1L1 was defined positions of the 4'-phosphopantetheine arm within the two catalytic domains and to predict N-terminal:intermediate and intermediate:C-terminal domain interfaces. PMID: 28414156
    5. The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for neural tube defects in the Chinese population. PMID: 26993122
    6. Data suggest that isoforms of FTHFD occur both in mitochondria and in cytosol; activity of cytosolic FTHFD appears to respond to supply of one-carbon groups in excess of those required for classical one-carbon metabolism. [REVIEW] PMID: 26567272
    7. JNK1/2 phosphorylate Bid at Thr59 within the caspase cleavage site in response to ALDH1L1. PMID: 25077544
    8. ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. PMID: 24953984
    9. one variant in the ALDH1L1 locus, rs2364368, was associated with incident ischemic stroke. PMID: 24651765
    10. The results in this study, for the first time, reveal that the mRNA and protein expressions of ALDH1L1 are significantly reduced in hepatocellular carcinoma tissues PMID: 21987076
    11. Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme. PMID: 21540484
    12. These studies support ALDH1L1 as a general CNS astroglial marker. PMID: 21046559
    13. inhibition of cell motility by ALDH1L1 associated with dephosphorylation of the actin depolymerizing factor cofilin by PP1 and PP2A PMID: 20729910
    14. down-regulation of FDH in tumors is proposed to be one of the cellular mechanisms that enhance proliferation. PMID: 12065246
    15. FDH antiproliferative effects on A549 cells include both G(1) cell cycle arrest and caspase-dependent apoptosis PMID: 12805405
    16. None of the snps that defined 3 separate haplotype blocks in the FTHFD gene, rs2365004, rs11923466, rs2886059, rs10934751, rs2276731, rs1823213 and rs4646701 were associated with prostate cancer risk. PMID: 19064578

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    GART family; Aldehyde dehydrogenase family, ALDH1L subfamily
  • 組織特異性：
    Highly expressed in liver, pancreas and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3978

    OMIM: 600249

    KEGG: hsa:10840

    STRING: 9606.ENSP00000377083

    UniGene: Hs.434435



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