在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cytoskeleton-associated protein 5 (CKAP5), partial

  • 中文名稱:
    Recombinant Human Cytoskeleton-associated protein 5(CKAP5) ,partial
  • 貨號(hào):
    CSB-YP617899HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Cytoskeleton-associated protein 5(CKAP5) ,partial
  • 貨號(hào):
    CSB-EP617899HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Cytoskeleton-associated protein 5(CKAP5) ,partial
  • 貨號(hào):
    CSB-EP617899HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Cytoskeleton-associated protein 5(CKAP5) ,partial
  • 貨號(hào):
    CSB-BP617899HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Cytoskeleton-associated protein 5(CKAP5) ,partial
  • 貨號(hào):
    CSB-MP617899HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CKAP5
  • Uniprot No.:
  • 別名:
    CKAP5; KIAA0097Cytoskeleton-associated protein 5; Colonic and hepatic tumor overexpressed gene protein; Ch-TOG
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments.
  • 基因功能參考文獻(xiàn):
    1. Eribulin binding to the tip of microtubules and subsequent loss of ch-TOG is a priming event leading to alterations in microtubule dynamics and breast cancer cell migration. PMID: 26497677
    2. Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with microtubule- associated protein TPX2. PMID: 26414402
    3. Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles. PMID: 24273164
    4. Data show that five genes CKAP5, KPNB1, RAN, TPX2 and KIF11 were shown to be essential for tumor cell survival in both head and neck squamous cell carcinoma (HNSCC)and non-small cell lung cancer (NSCLC), but most particularly in HNSCC. PMID: 23444224
    5. These observations indicate that EB1 and ch-TOG regulate microtubule organisation differently via distinct regions in the plus ends of microtubules. PMID: 23251535
    6. Clathrin promotes centrosome maturation by stabilizing the microtubule-binding protein ch-TOG, defining a novel role for the clathrin-ch-TOG complex. PMID: 22891263
    7. Data show that ILK performs its centrosome clustering activity in a centrosome-dependent, manner through the microtubule regulating proteins TACC3 and ch-TOG. PMID: 20838383
    8. the association between aurora A phosphorylation and spindle apparatus; regulation from aurora A is mediated by CHC in recruiting phospho-TACC3 and subsequently ch-TOG to mitotic spindles. PMID: 20566684
    9. TOG has roles during mitosis in focusing MT minus ends at spindle poles, maintaining centrosome integrity, and contributing to spindle bipolarity PMID: 14718566
    10. TOG mediates the association of hnRNP A2-positive granules with microtubules during transport and/or localization PMID: 15703215
    11. Hsp90 is required to localize ch-TOG to the mitotic spindle. PMID: 17376965
    12. A novel function of Aurora-A, the regulation of ch-TOG and MCAK localization, in a common pathway in control of spindle pole integrity. PMID: 18663358
    13. ch-Tog has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK, and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity. PMID: 18809577
    14. Data hypothesize that TOGp is required for chromosome motility as a downstream consequence of reduced microtubule dynamics and/or density. PMID: 19373773

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
  • 蛋白家族:
    TOG/XMAP215 family
  • 組織特異性:
    Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 28959

    OMIM: 611142

    KEGG: hsa:9793

    STRING: 9606.ENSP00000432768

    UniGene: Hs.201253



主站蜘蛛池模板: 久久精品夜夜夜夜夜久久| 国产 | 久你欧洲野花视频欧洲1| 特级做a爰片毛片免费看无码| 久久综合狠狠色综合伊人| 色窝窝色蝌蚪在线视频| 国产精品自在线拍国产| 国产xxxx做受视频| 国产丝袜在线精品丝袜| 欧美精品18videosex性欧| 欧美乱码卡一卡二卡三新区| 内射白浆一区二区在线观看 | 亚洲综合网站精品一区二区| 亚洲欧美日韩综合久久久久久 | 寂寞骚妇被后入式爆草抓爆| 丰满的少妇xxxxx人| 人摸人人人澡人人超碰97| 一区二区传媒有限公司| 国产乱人伦app精品久久| 色狠狠一区二区三区香蕉| 亚洲狠狠色丁香婷婷综合| 国产午夜福利不卡在线观看| 久久99精品久久久久蜜芽| 狠狠色综合激情丁香五月| 欧美人与动欧交视频| 无遮挡午夜男女xx00动态| 国产精品麻豆aⅴ人妻| 亚洲综合区图片小说区| 欧美老妇与zozoz0交| 欧美人与禽猛交狂配| 天天综合网亚在线| 欧美成人www免费全部网站| 极品人妻videosss人妻| 亚洲 欧美 国产 日韩 精品| 亚洲成av人片无码bt种子下载| 99精品国产丝袜在线拍国语| 久久久国产乱子伦精品| 欧美精品无码一区二区三区 | 中国熟妇牲交视频| 久久久精品456亚洲影院| 2020无码天天喷水天天爽| 无罩大乳的熟妇正在播放|