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  4. Recombinant Human Cytoskeleton-associated protein 4 (CKAP4)

Recombinant Human Cytoskeleton-associated protein 4 (CKAP4)

  • 中文名稱：
  • 貨號(hào)：
    CSB-YP005453HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-EP005453HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-EP005453HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-BP005453HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號(hào)：
    CSB-MP005453HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cytoskeleton-associated protein 4; 63-kDa cytoskeleton-linking membrane protein; Climp-63; p63; CKAP4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mediates the anchoring of the endoplasmic reticulum to microtubules.; High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.
  • 基因功能參考文獻(xiàn)：
    1. Both DKK1 and CKAP4 are frequently expressed in pancreatic and lung tumours, and their simultaneous expression is negatively correlated with prognosis. PMID: 28514532
    2. CKAP4 has a role as a Dickkopf1 receptor and in pancreatic and lung tumor progression PMID: 27322059
    3. Human Prostate Basal cell hyperplasia is an expansion of p63. PMID: 28795417
    4. APF binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain PMID: 28893174
    5. The still rudimentary information of how CLIMP-63 fulfills these different roles, what these are exactly and how post-translational modifications control them, will be discussed. PMID: 25849921
    6. Although VIMP can interact with CLIMP-63 and Syn5L, it does not interact with MT-binding ER proteins (such as Reep1) that shape the tubular smooth ER PMID: 25008318
    7. revealed that CKAP4 could associate with EGFR at basal status and the complex was reduced upon EGF stimulation, leading to release EGFR into cytoplasm PMID: 24838946
    8. Single nucleotide polymorphisms in p63 are implicated in the etiology of nonsyndromic bladder-exstrophy-epispadias complex. PMID: 23913486
    9. Here we report that the combination of p63, a master regulator of epidermal development and differentiation, and KLF4, a regulator of epidermal differentiation, is sufficient to convert dermal fibroblasts to a keratinocyte phenotype. PMID: 23921950
    10. CKAP4 was correlated with favorable clinical outcome and was an independent predictor for overall survival in hepatic cholangiocarcinoma patients. PMID: 23665508
    11. p63 positively regulates desmosome adhesion by directly controlling the expression of several desmosome genes, including Dsp, Dsc3 and Dsg1. PMID: 23108156
    12. CLIMP63 regulates the luminal diameter within the endoplasmic reticulum and may play a role in regulating the formation of endoplasmic reticulum sheets. PMID: 21111237
    13. The results define CLIMP-63 as a novel protein interactor and regulator of Dicer function, involved in maintaining Dicer protein levels in human cells. PMID: 23047949
    14. Treatment of airway epitheial cells (AEC) with SP-A, monoclonal antibodies to CKAP4/P63, or CKAP4/P63-specific small interfering RNA decreased the binding of purified alginate exopolysaccharide to AEC. PMID: 22966120
    15. This study identifies specific changes in skin structural biology and signalling pathways that result from mutant p63 and provides new molecular insight into the AEC syndrome phenotype PMID: 22329826
    16. CCN2 regulation by antiproliferative factor involves CKAP4 nuclear translocation and binding to the CCN2 promoter. PMID: 22438586
    17. Tumor markers, p63 and high molecular weight cytokeratin, may be utilised in the distinction between urothelial carcinoma with prostatic stromal invasion and urothelial carcinoma with colonisation of prostatic ducts and acini. PMID: 22406481
    18. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma. PMID: 22056955
    19. This study found a consistent expression profile and localization analysis of p63 and GM1 in primary keratinocytes and in human epidermal biopsies. PMID: 21820419
    20. Telomere length in Sjogren syndrome is shorter and associated with lower levels of expression of p63 and nucleostemin than in non-Sjogren syndrome. PMID: 21655359
    21. Synthetic as-antiproliferative factor inhibits cell proliferation in T24 bladder carcinoma cells via the CKAP4 receptor PMID: 21143984
    22. Data demonstrate an important role for the PI3-kinase-Akt pathway in intracellular transport of surfactant protein A receptor P63. PMID: 20870746
    23. p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development. PMID: 20808887
    24. p63 was not found to be highly sensitive for squamous cell carcinoma PMID: 20184665
    25. I510T mutation of p63 was detected in both RHS and AEC syndrome patients and mutation of S541 residue can lead to either RHS (S541Y) or AEC syndrome (S541F). PMID: 20156774
    26. evidence to support the hypothesis that p63 is the functional tPA binding site on VSMC PMID: 12913003
    27. The ectrodactyly, absence of radius side part palm and split foot malformation are caused by the mutation of base pair at number 665 of the exon 5 of P63. PMID: 15476176
    28. CLIMP-63-mediated stable anchoring of the endoplasmic reticulum (ER) to microtubules is required to maintain the spatial distribution of the ER during interphase. PMID: 15703217
    29. is not responsible for autosomal-dominant amelogenesis imperfecta PMID: 16546853
    30. cytoskeleton-associated protein 4/p63 (CKAP4/p63), a type II transmembrane receptor, binds with high affinity to APF PMID: 17030514
    31. Olomoucine, a CDK inhibitor, up-regulates CKAP4, a cytoskeleton-linking membrane protein. PMID: 17975794
    32. Identification of CKAP4/p63 as a substrate of DHHC2, a putative tumor suppressor. PMID: 18296695
    33. CK MNF116 and p63 were useful in identifying squamous cell carcinomas with single cell infiltration. PMID: 18333895
    34. Results substantiate the role of P63 as a lung surfactant protein-A receptor protein localized on the surface of lung type II cells. PMID: 18708633
    35. DHHC2-mediated palmitoylation of CKAP4 has a role in opposing cancer-related cellular behaviors. PMID: 19144824
    36. p73 and p63, but not p53, are modulated during the cell cycle PMID: 19861536
    37. The p62/p63 protein was first identified because it is palmitoylated during mitosis. PMID: 1730740
    38. Purification and cloning of p62/p63. PMID: 8566419

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16991

    KEGG: hsa:10970

    STRING: 9606.ENSP00000367265

    UniGene: Hs.74368



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