在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Cysteinyl leukotriene receptor 2 (CYSLTR2), partial

Recombinant Human Cysteinyl leukotriene receptor 2 (CYSLTR2), partial

  • 中文名稱：
    Recombinant Human Cysteinyl leukotriene receptor 2(CYSLTR2),partial
  • 貨號：
    CSB-YP006466HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cysteinyl leukotriene receptor 2(CYSLTR2),partial
  • 貨號：
    CSB-EP006466HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cysteinyl leukotriene receptor 2(CYSLTR2),partial
  • 貨號：
    CSB-EP006466HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cysteinyl leukotriene receptor 2(CYSLTR2),partial
  • 貨號：
    CSB-BP006466HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cysteinyl leukotriene receptor 2(CYSLTR2),partial
  • 貨號：
    CSB-MP006466HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CYSLTR2; CYSLT2; CYSLT2R; PSEC0146; Cysteinyl leukotriene receptor 2; CysLTR2; G-protein coupled receptor GPCR21; hGPCR21; G-protein coupled receptor HG57; HPN321
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
  • 基因功能參考文獻：
    1. Its mutation is found in patients with meningeal melanocytic tumour. PMID: 29476293
    2. our study identifies CYSLTR2 L129Q alterations as a previously unrecognized activating mutation in blue nevi, occuring in a mutually exclusive fashion with known GNAQ and GNA11 mutations. PMID: 27934878
    3. The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children PMID: 27221082
    4. findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Galphaq signaling in uveal melanoma pathogenesis PMID: 27089179
    5. CysLTRs -1 and -2 seem to be involved in lymphocyte maturation that occurs in tonsils, without influence of allergies. PMID: 27115897
    6. CysLT2 receptors were expressed in lung specimens isolated from asthma subjects. Activation of CysLT2 receptors may contribute to antigen-induced bronchoconstriction in certain asthma population. PMID: 26433531
    7. Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT receptor PMID: 25839425
    8. CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH. PMID: 25760841
    9. Suggest that endothelial and nonendothelial CysLT2R niches have separate roles in mediating inflammatory responses in ischemic/perfusion injury. PMID: 24285579
    10. ATRA treatment induces CysLT(2)R mRNA and protein expression in colon cancer cell lines PMID: 23829413
    11. CysLT2 receptor plays a primary role in the vascular responses in the upper respiratory tract. PMID: 23524649
    12. increased expression in tonsillar tissues of Chinese children with sleep-disordered breathing PMID: 22634478
    13. There is a protective role against tumor progression for CysLT(2)R and that it highlights new possibilities to regulate the CysLT(2)R. PMID: 22194989
    14. The synthesis of cys-LTs from LTA(4) by endothelial cells is directly associated with the activation of the CysLT(2) receptor in a typical autocrine fashion. PMID: 21753081
    15. Cysteinyl leukotriene receptor 2 gene polymorphism -1220 A/C is not associated with atopic dermatitis or psoriasis vulgaris in Japanese patients. PMID: 21352274
    16. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner PMID: 21203429
    17. results indicate that the M201V polymorphism drastically affects CysLT(2) responses to LTD(4) and less to LTC(4) PMID: 20966037
    18. Data show functional expression of CysLT1 and 2 receptors on human platelets and demonstrate that CysLTs induced the release of significant amounts of RANTES, which suggests a novel role for human platelets in CysLT-mediated allergic inflammation. PMID: 20433311
    19. Ca2+ fluxes elicited by CysLT in these vascular endothelial cells emanate from perturbation of the CysLT2R, rather than the expected CysLT1R. PMID: 12816881
    20. mast cells express the type 2 receptor for cysLTs (CysLT2R) as well, and that the amount of surface CysLT2R protein increases in response to priming with IL-4 PMID: 13679572
    21. Mutations in cysteinyl leukotriene 2 receptor is associated with atopy PMID: 14515063
    22. identified three novel exons in the 5' untranslated region of CYSLTR2 and eight novel polymorphisms; the -1220A > C polymorphism is associated with the development of asthma PMID: 15454733
    23. 601A>G coding polymorphism in the CYSLT2 receptor alters the potency of LTD4 PMID: 15475736
    24. Endothelial CysLT2R increases vascular permeability & recruits neutrophils via enhanced P-selectin expression. It may participate in hypotensive anaphylaxis. CysLT2R-dependent NO formation interacts with superoxide to form peroxynitrite. PMID: 15545522
    25. CysLT 1 expression predominates on inflammatory leukocytes in aspirin-sensitive rhinosinusitis. Effects of cysteinyl leukotrienes on glands and epithelium may be mediated predominantly through cysLT 2. Potentially important therapeutic implications. PMID: 15696087
    26. Because LTD4 and thrombin are likely to be formed concomitantly in vivo, cysLT2-R and PAR-1 may cooperate to augment vascular injury. PMID: 16606835
    27. CYSLTR2 and ALOX5 polymorphisms may predispose a minority of individuals to excessive cysteinyl-leukotriene concentrations, yielding a distinct asthma phenotype most likely to respond to leukotriene modifier pharmacotherapy. PMID: 17460547
    28. CysLT1R and CysLT2R expression in monocytes can be regulated by CysLT itself and T(H)2 cytokines at the transcriptional level. PMID: 17941281
    29. Since prostacyclin is a major blood vessel-protective and anti-thrombotic eicosanoid, the EC cysLT(2)-R may limit its otherwise pro-inflammatory actions through a protective Ca(2+)/calcineurin/NFAT-dependent COX-2 feedback loop PMID: 17991613
    30. the potential implication of CysLT2 in the inflammatory response through the modulation of chemokine gene transcription. PMID: 18048362
    31. Our results reveal that CysLT(2)R can mediate inflammatory reactions in a vascular bed-specific manner by altering transendothelial vesicle transport-based vascular permeability. PMID: 18779380
    32. increase in urinary levels is associated with anaphylaxies and eosinophilic pneumonia PMID: 18946233
    33. The sequence variants of CysLTR2 may affect its transcription and the stability of its mRNA, resulting in altered expression of CysLTR2 protein, which in turn causes some asthmatics to be susceptible to aspirin hypersensitivity PMID: 19840403

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
  • 數據庫鏈接：

    HGNC: 18274

    OMIM: 605666

    KEGG: hsa:57105

    STRING: 9606.ENSP00000282018

    UniGene: Hs.253706



主站蜘蛛池模板： 久久天天躁狠狠躁夜夜2019| 性色欲情网站| 中文成人无码精品久久久动漫| 少妇的渴望hd高清在线播放| 精品国产av一二三四区| 午夜精品久久久久久久久久久久| 毛片完整版的免费观看| 成熟老妇女毛茸茸的做性| 亚洲精品久久| 99精品久久久久久久婷婷| www激情内射在线看| 亚洲国产日韩欧美综合a| 国产av丝袜旗袍无码网站 | 久久人人爽人人爽人人片av高清| 丰满少妇弄高潮了www| 九九热线有精品视频| 国产网曝门亚洲综合在线| 免费看欧美成人a片无码| 国产成人综合色在线观看网站| 99久久精品国产一区二区三区| 久久青青草原国产最新片完整| 成人做爰www网站视频下载| 日本免费大黄在线观看| 亚洲高清无在码在线电影不卡| 久久亚洲精品无码av宋| 亚洲日本在线电影| 精品女同一区二区三区免费站| av高清无码 在线播放| 怡红院成永久免费人视频新的| 人与嘼交av免费| 久久综合给综合给久久| 国内精品自在自线视频| 国产精品av在线| 国产精品无码永久免费不卡| 女被啪到深处喷水gif动态图| 国产又色又爽又刺激在线观看| 日本乱子人伦在线视频| 欧美片内射欧美美美妇| 很黄很色60分钟在线观看| 香蕉影院在线观看| 中文字幕无码日韩欧免费软件|