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  4. Recombinant Human Corticotropin-releasing factor-binding protein (CRHBP)

Recombinant Human Corticotropin-releasing factor-binding protein (CRHBP)

  • 中文名稱：
    Recombinant Human Corticotropin-releasing factor-binding protein(CRHBP)
  • 貨號：
    CSB-YP005964HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Corticotropin-releasing factor-binding protein(CRHBP)
  • 貨號：
    CSB-EP005964HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Corticotropin-releasing factor-binding protein(CRHBP)
  • 貨號：
    CSB-EP005964HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Corticotropin-releasing factor-binding protein(CRHBP)
  • 貨號：
    CSB-BP005964HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Corticotropin-releasing factor-binding protein(CRHBP)
  • 貨號：
    CSB-MP005964HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CRHBP
  • Uniprot No.：
  • 別名：
    CRHBP; CRFBPCorticotropin-releasing factor-binding protein; CRF-BP; CRF-binding protein; Corticotropin-releasing hormone-binding protein; CRH-BP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    25-322
  • 氨基酸序列
    YLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ LEPYELENPN GNSIGEFCLS GL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
  • 基因功能參考文獻：
    1. found no differences in genotype distributions between heroin-dependent subjects and controls. However, identified a prominent interaction of one variant of the CRHBP gene predicting the risk of heroin relapse in the chronically stressed subjects. PMID: 29853227
    2. A measure of stressful life events was significantly predictive of alcohol use/misuse. In addition, this association was significantly dependent upon the number of putative risk variants at rs1715749, a single-nucleotide polymorphism (SNP) in CRHBP. PMID: 26751645
    3. We describe for the first time tumor specific epigenetic silencing of CRHBP and statistical association with aggressive tumors thus suggesting the CRH system to contribute to the development of kidney cancer. PMID: 27695045
    4. Genetic polymorphism rs7718461 in the CRHBP gene showed significant association with overall pain severity during the year after motor vehicle collision. PMID: 26447706
    5. Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD and depressive symptoms PMID: 24075295
    6. Significant main effects on children's cortisol reactivity were found for loci on CRHR1 and CRHBP. PMID: 23131710
    7. A significant association was observed in Blacks, Hispanics and Whites between birth weight and maternal CRH-BP single nucleotide polymorphism genotypes. PMID: 22984453
    8. There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and restrained eating condition (p = 0.033 PMID: 22286724
    9. CRHBP variation may predispose, independently and additively, to suicidal behavior in individuals who have experienced childhood trauma. PMID: 21978546
    10. interaction of CRHR1 SNP rs110402 and SNP rs3811939 predicts high risk of comorbid alcoholism in schizophrenic patients PMID: 21810631
    11. results extend recent preclinical and clinical findings implicating the CRH-BP in stress-related alcoholism and confirm the role of the Asp40 allele of the OPRM1 gene in reward-driven alcohol phenotypes PMID: 21039637
    12. genotype analyses yielded significant association between CRHBP and suicide attempt (P = 0.035); interaction analysis showed significant interaction between CRH receptor type 1 and CRHBP in influencing suicide attempt and severity of suicidal behaviour PMID: 18838498
    13. SNP rs10473984 affects response to citalopram in African American and Hispanic patients with major depressive disorder PMID: 20368512
    14. Detected in myometrium. Widespread expression of CRH system in gestational tissue suggests paracrine role CRH in birth process (e.g. effects on macrophages and endothelial cells). PMID: 12784189
    15. The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression. PMID: 14573312
    16. The placenta was identified as the main site of the CRH-BP mRNA expression during the last weeks of pregnancy PMID: 15072543
    17. analysis of regulation and function of CRH-BP [review] PMID: 16368564
    18. We found a significant decrease in CRF-BP mRNA levels in the basolateral amygdala of male bipolar and male schizophrenic subjects and the lateral amygdala of male bipolar subjects compared to controls. PMID: 16482088
    19. expression of CRH-BP, CRH-R1 and CRH-R2 in uterine tissues is down-regulated during pregnancy; the most pronounced down-regulation of CRH-BP and CRH-R2 occurred in laboring cervix, irrespective the length of gestation PMID: 16734917
    20. Five single nucleotide polymorphisms (SNPs) and a deletion polymorphism in the CRF-BP gene were genotyped and the haplotype block structure of the gene was assessed. PMID: 17599466
    21. An isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder. PMID: 17728670
    22. CRH-BP modulates CRH which influences cortical and hippocampal EEG activity and is the primary mediator of the neuroendocrine stress response. this suggest a likely role for CRH-BP in stress-related alcoholism. PMID: 18974851
    23. In white women, non-smokers with the CT genotype at CRH-BP + 17487 have lower Nugent scores than non-smokers with the TT genotype; whereas smokers with the CT genotype have higher Nugent scores than smokers with the TT genotype PMID: 19131402

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    CRF-binding protein family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2356

    OMIM: 122559

    KEGG: hsa:1393

    STRING: 9606.ENSP00000274368

    UniGene: Hs.115617



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