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  4. Recombinant Human Coronin-7 (CORO7), partial

Recombinant Human Coronin-7 (CORO7), partial

  • 中文名稱：
    Recombinant Human Coronin-7(CORO7) ,partial
  • 貨號：
    CSB-YP005819HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Coronin-7(CORO7) ,partial
  • 貨號：
    CSB-EP005819HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Coronin-7(CORO7) ,partial
  • 貨號：
    CSB-EP005819HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Coronin-7(CORO7) ,partial
  • 貨號：
    CSB-BP005819HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Coronin-7(CORO7) ,partial
  • 貨號：
    CSB-MP005819HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CORO7
  • Uniprot No.：
  • 別名：
    0610011B16Rik; 70 kDa WD repeat tumor rejection antigen homolog; CORO 7; Coro7; CORO7_HUMAN; Coronin-7; Coronin7; Crn7; FLJ22021; FLJ44188; POD1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

相關產品

靶點詳情

  • 功能：
    F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
  • 基因功能參考文獻：
    1. Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function PMID: 25887538
    2. Results show that enforced targeting of Crn7 to TGN 9trans-Golgi network) bypasses the requirement of K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi trafficking. PMID: 24768539
    3. Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex. PMID: 21130766
    4. role in the organization of intracellular membrane compartments and vesicular trafficking rather than in remodeling the cytoskeleton PMID: 15327992
    5. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi PMID: 16905771
    6. Sequential events of protein interaction and posttranslational modification result in the membrane targeting of Crn7. PMID: 18581049

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  • 亞細胞定位：
    Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
  • 蛋白家族：
    WD repeat coronin family
  • 組織特異性：
    Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.
  • 數據庫鏈接：

    HGNC: 26161

    OMIM: 611668

    KEGG: hsa:79585

    STRING: 9606.ENSP00000460885

    UniGene: Hs.437957



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