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  4. Recombinant Human Collagen alpha-1 (V) chain (COL5A1), partial

Recombinant Human Collagen alpha-1 (V) chain (COL5A1), partial

  • 中文名稱：
    Recombinant Human Collagen alpha-1(V) chain(COL5A1) ,partial
  • 貨號：
    CSB-YP005748HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(V) chain(COL5A1) ,partial
  • 貨號：
    CSB-EP005748HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(V) chain(COL5A1) ,partial
  • 貨號：
    CSB-EP005748HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(V) chain(COL5A1) ,partial
  • 貨號：
    CSB-BP005748HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(V) chain(COL5A1) ,partial
  • 貨號：
    CSB-MP005748HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    AB collagen; Alpha 1 type V collagen; Alpha 2 type V collagen; CO5A1_HUMAN; COL5A1; Col5A2; COL5A2 protein; Col5A3; Collagen alpha 1(V) chain; Collagen alpha 2 (V) chain precursor; Collagen alpha 2(V) chain; Collagen alpha 3(V) chain; Collagen alpha-1(V) chain; Collagen fetal membrane A polypeptide; Collagen type V alpha 1; Collagen type V alpha 2; Collagen type V alpha 3; Collagen V alpha 2 polypeptide; CollagenV; MGC105115; OTTHUMP00000064637; Pro alpha 1 type V collagen; Pro alpha 3(V) collagen; Procollagen alpha 2(V); Type V preprocollagen alpha 2 chain
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
  • 基因功能參考文獻：
    1. Mutations affecting COL5A1 or COL5A2 are responsible for spectrum of mucocutaneous, ocular and facial features in 62 classical Ehlers-Danlos syndrome patients. PMID: 28485813
    2. COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby PMID: 29143592
    3. COL5A1 may contribute the metastasis of lung adenocarcinoma. PMID: 29702185
    4. sex-specific allele combinations of BGN, COL5A1, and DCN, as well as eight miRNA recognition sequences, were associated with altered susceptibility to anterior cruciate ligament ruptures PMID: 28927971
    5. Variants of the COL5A1 gene seem to influence quadriceps muscle-tendon stiffness. PMID: 27717059
    6. Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels. PMID: 28618934
    7. Data suggest that, compared with obese white women, obese black women exhibit higher expression of HIF1A (hypoxia inducible factor 1 alpha), COL5A1 (collagen Valpha1), and COL6A1 (collagen VIalpha1) in gluteal but not abdominal subcutaneous adipose tissue depots; up-regulation of expression of these proteins correlates with reduced insulin sensitivity in black women only. PMID: 27628582
    8. COL5A1 mutation is associated with Adrenocortical Adenomas. PMID: 27389594
    9. Gene expression levels of three randomly selected DEGs, VCAN, COL5A1 and KCNJ16, were examined using RT-PCR in 10 ATC samples.. angiogenesis was activated by the high expression of CTHRC1, VCAN and POSTN, providing necessary nutrition for tumor cells PMID: 27599582
    10. COL5A1 rs12722 was found to be associated with severity of musculoskeletal injuries but not with incidence of musculoskeletal injuries in top-level soccer players. PMID: 25583227
    11. Data (including data from studies in knockout mice) suggest causative role for collagen(V)alpha1 hypersensitivity/autoimmunity in pathogenesis of atherosclerosis; both immune tolerance and reduction of plaque burden are dependent on interleukin 35. PMID: 26721885
    12. Familial Ehlers-Danlos syndrome with lethal arterial events caused by a mutation in COL5A1 is described in a mother and her two sons, who all died at an early age from arterial ruptures. PMID: 25845371
    13. Individuals with the BstUI A1 allele and DpnII B2 allele of the COL5A1 gene have a high likelihood of developing symptoms of the tennis elbow PMID: 25896984
    14. In conclusion, the novel main finding of this study was a significant interaction between the COL5A1 rs12722 T/C and COL12A1 rs970547 A/G variants and risk of anterior cruciate ligament injury. PMID: 25073002
    15. variants within the functional COL5A1 3'-untranslated region are associated with idiopathic carpal tunnel syndrome PMID: 24966028
    16. Running economy, the energy cost or oxygen uptake for a given submaximal running speed, was not associated with variants within the COL5A1gene. PMID: 25188268
    17. found down-regulation of COL5A1 in osteo-induced cultures at days 21 and 28, when the mineralized matrix accumulates PMID: 25132375
    18. High Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma. PMID: 25449434
    19. COL5A1 mutations led to structural tendon pathology and low tendon stiffness in classic Ehlers-Danlos syndrome PMID: 25122555
    20. Tendon properties do not seem to be influenced by the COL5A1 rs12722 gene variant. PMID: 24643429
    21. Provide evidence for a relationship between COL5A1, running performance, and joint range of motion. PMID: 24085259
    22. data confirm that COL5A1 and COL5A2 are the major, if not the only, genes involved in classic Ehlers-danlos syndrome PMID: 23587214
    23. The COL5A1 3'-UTR markers rs71746744, rs16399 and rs1134170 are associated with chronic Achilles tendinopathy. PMID: 23347277
    24. study shows that over 90% of patients, which strictly satisfy all major Villefranche criteria for classic Ehlers-Danlos Syndrome (EDS)harbor a type V collagen defect which indicates that this is the major--if not only--cause of classic EDS PMID: 22696272
    25. SNPs in the COL5A1 region, which regulate normal variation in CCT, may play a role in the thinning associated with keratoconus. PMID: 23513063
    26. An large number of hydroxyproline residues were mapped to the X-positions of Gly-X-Y triplets of the alpha1(V) collagen chain. PMID: 23060441
    27. Single nucleotide polymorphisms in COL5A1 gene is associated with central corneal thickness in glaucoma. PMID: 22814818
    28. collagen V may be expressed in skin as different subtypes with important but distinct roles in matrix organization and stability. PMID: 22437311
    29. The association between COL5A1 BstUI RFLP and sit and reach (SR) ROM in an apparently healthy and physically active cohort was investigated. The COL5A1 BstUI RFLP was found to be associated with SR ROM, particularly with increasing age. PMID: 21362053
    30. The COL5A1 genotype was found to be significantly associated with performance in a 56 km ultra-endurance run. The COL5A1 gene may alter muscle-tendon stiffness. PMID: 21934170
    31. This study suggests a fetal association of COL5A2 and a combined fetal-maternal association of COL5A1 with spontaneous preterm delivery. PMID: 22208904
    32. Before bronchiolitis obliterans, lung transplantation patients had antibodies to Col-V,alpha1(V) & alpha2(V) but at clinical diagnosis of BOS, antibodies were restricted to alpha1(V). Lung biopsy indicating that alpha1(V)epitopes are exposed. PMID: 22132895
    33. phenotypes associated directly or indirectly with the mechanical properties of musculoskeletal soft tissue [review] PMID: 21697718
    34. Tendinopathic phenotype is associated with increased COL5A1 mRNA stability. PMID: 21609763
    35. This is the first study to identify the COL5A1 BstUI RFLP as a marker for endurance running performance. PMID: 20798666
    36. role of mutations in Ehlers-Danlos syndrome (Review) PMID: 20847697
    37. GWAS summary data, COL5A1 was genome-wide significant (beta = 0.13 SD, P = 5.1 x 10(-8)), together with two additional novel loci. The second new locus (defined by rs1034200) was 5 kb from the AVGR8 gene PMID: 20719862
    38. The authors found no interaction between the matrix metallopeptidase 3 rs679620 variant, the COL5A1 BstUI restriction fragment length polymorphism and range of motion measurements. PMID: 20359947
    39. Investigates the association of sequence variants within COL5A1 and musculotendinous range of motion. Data suggest that the COL5A1 BstUI RFLP is independently associated with lower limb ROM. PMID: 19422640
    40. Heterozygous mutations in COL3A1 is associated with arterial rupture in classic Ehlers-Danlos syndrome. PMID: 20635400
    41. The formation of [alpha1(V)](3) homotrimers was considerably favored over the heterotrimer [alpha1(V)](2)alpha2(V). PMID: 20625483
    42. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20719862
    43. Variants within the MMP3 gene are associated with Achilles tendinopathy and the MMP3 gene variant rs679620 and the COL5A1 marker rs12722 interact to modify the risk of tendinopathy. PMID: 19042922
    44. The CC genotype of the COL5A1 BstUI RFLP was underrepresented in female participants with anterior cruciate ligament ruptures. PMID: 19654427
    45. Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. PMID: 12145749
    46. Antisense oligonucleotides reduced synthesis of type V procollagen alpha1 chain. In addition, both antisense oligonucleotides partially reduced type V procollagen alpha1 chain mRNA expression. PMID: 14504037
    47. analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer PMID: 15136578
    48. Finds the COL5A1 BstUI RFLP associated with Achilles tendon pathology and more specifically, chronic ATP. PMID: 16430677
    49. In the eye, COL5A1 and COL5A2 mutations manifest as abnormally thin and steep corneas with floppy eyelids. PMID: 16431952
    50. Collagen type V alpha 1 was efficiently cleaved by BMP-1 indicating that the triple helix is not required for enzyme activity. PMID: 17407447

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  • 相關疾病：
    Ehlers-Danlos syndrome, classic type (EDS)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 數據庫鏈接：

    HGNC: 2209

    OMIM: 120215

    KEGG: hsa:1289

    STRING: 9606.ENSP00000360882

    UniGene: Hs.210283



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