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  4. Recombinant Human Coilin (COIL)

Recombinant Human Coilin (COIL)

  • 中文名稱：
    Recombinant Human Coilin(COIL)
  • 貨號：
    CSB-YP005713HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Coilin(COIL)
  • 貨號：
    CSB-EP005713HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Coilin(COIL)
  • 貨號：
    CSB-EP005713HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Coilin(COIL)
  • 貨號：
    CSB-BP005713HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Coilin(COIL)
  • 貨號：
    CSB-MP005713HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    COIL
  • Uniprot No.：
  • 別名：
    CLN 80; CLN80; COIL; COIL_HUMAN; Coilin; Coilin p80; p80; P80 coilin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-576
  • 氨基酸序列
    MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG FSSGAFLGLY LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG DINLSLRKAK KRAFQLEEGE ETEPDCKYSK KHWKSRENNN NNEKVLDLEP KAVTDQTVSK KNKRKNKATC GTVGDDNEEA KRKSPKKKEK CEYKKKAKNP KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS KESPSSSSES ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR GRPGPGLSSQ TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN LFSWKGAKGR GMRGRGRGRG HPVSCVVNRS TDNQRQQQLN DVVKNSSTII QNPVETPKKD YSLLPLLAAA PQVGEKIAFK LLELTSSYSP DVSDYKEGRI LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV EYAVTQESKI TVFWKELIDP RLIIESPSNT SSTEPA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
  • 基因功能參考文獻：
    1. The existence of chromatolysis and eccentric nuclei in SMA motor neurons correlates with Cajal body disruption and nucleolar relocalization of coil in, a Cajal body marker. PMID: 22302308
    2. Data indicate that annexin A2 overexpression in microsatellite instability (MIN) cells induces disassembly and colocalization of coilin with centromeres. PMID: 25347736
    3. Authors summarize what has been learned in the past 25 years about coilin's structure, post-transcriptional modifications, and interactions with RNA and proteins. [Review] PMID: 25970135
    4. The study shows that coilin-KO human cells that lack Cajal bodies are phenotypically normal with respect to telomere homeostasis. PMID: 25477378
    5. Coilin couples snRNA and snoRNA biogenesis, making cajal bodies the cellular hub of small ncRNA metabolism. PMID: 25514182
    6. The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly. PMID: 24413165
    7. Results suggest that UBL5 could be targeted to Cajal bodies (CBs) via its interaction with coilin. PMID: 23726919
    8. coilin is subjected to regulated specific proteolysis by calpain, and this processing may play a role in the regulation of coilin activity and Cajal body formation PMID: 23064547
    9. Data indicate coilin involvement in the processing of telomerase RNA both in vitro and in vivo. PMID: 23274112
    10. investigated the role of coilin in the DNA damage response and found that coilin reduction correlated with significantly increased levels of soluble gammaH2AX in etoposide treated U2OS cells PMID: 22986342
    11. new characteristics of coilin in vitro PMID: 22558428
    12. These results emphasize the role of coilin phosphorylation in the formation and activity of Cajal bodies. PMID: 21991343
    13. Results identify a novel and unexpected function for coilin, independent of its role in snRNP biogenesis, establishing a new link between the DNA damage response and the inhibition of rRNA synthesis. PMID: 21289084
    14. Data demonstrate by NMR methods that the carboxy-terminal region contains a Tudor domain. PMID: 20875822
    15. results suggest the existence of a dynamic flux of coilin between Cajal bodies, nucleoplasm and nucleolus, and indicate that coilin methylation plays a key role in this process PMID: 20449600
    16. in addition to affecting coilin-coilin interaction and localization in the nucleus, the phosphorylation state of coilin also impacts its interaction with SMN and SmB' and may play a role in controlling U snRNP cycling through the Cajal bodies. PMID: 19997741
    17. The level of snRNP protein expression and snRNP assembly, rather than the expression levels of p80-coilin, may be a key trigger for Cajal body formation in stable HeLa cell lines. PMID: 11792806
    18. Coilin is a Cajal body marker; its methylation regulates nuclear body formation. PMID: 12361597
    19. Specific regions within the C-terminus of coilin, the Cajal Body marker protein, are responsible for regulating the number of nuclear foci. Coilin from various species shows different tendencies to form nuclear foci. PMID: 12482916
    20. SMN and coilin interact differentially with Cajal bodies and have roles in the pathway for reassembly of nucleoli and Cajal bodies following mitosis PMID: 12679382
    21. p80 coilin protein co-localizes with ataxin-1 aggregates in the nucleoplasm PMID: 12757932
    22. specific EB-1/AIDA-1 isoforms, such as AIDA-1c, may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells PMID: 15862129
    23. Direct interactions between the Cajal body (CB) protein coilin and the promyelocytic leukemia (PML) body protein PIASy have a role in mediating association of CBs to PML bodies. PMID: 16219678
    24. Complexes of proteasome activator subunit gamma/coilin found in Cajal body - levels of complex increased by UV rays. PMID: 17088425
    25. Ectopic expression of AGAP2 causes both BRAG2 and the coiled bodies' marker coilin to accumulate in nucleoli. PMID: 17461797
    26. These findings demonstrate that coilin modifications or levels impact artificial reporter splicing, possibly by influencing small nuclear ribonucleoprotein biogenesis. PMID: 18322647
    27. FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. PMID: 18677100
    28. Data support a model whereby coilin is the target of an uncharacterized signal transduction cascade that responds to the increased transcription and snRNP demands found in transformed cells. PMID: 19435804

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  • 亞細胞定位：
    Nucleus. Nucleus, Cajal body.
  • 蛋白家族：
    Coilin family
  • 組織特異性：
    Found in all the cell types examined.
  • 數據庫鏈接：

    HGNC: 2184

    OMIM: 600272

    KEGG: hsa:8161

    STRING: 9606.ENSP00000240316

    UniGene: Hs.532795



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