Recombinant Human Coiled-coil domain-containing protein 11 (CCDC11)

中文名稱：

Recombinant Human Coiled-coil domain-containing protein 11(CCDC11)
貨號：

CSB-YP856981HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Coiled-coil domain-containing protein 11(CCDC11)
貨號：

CSB-EP856981HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Coiled-coil domain-containing protein 11(CCDC11)
貨號：

CSB-EP856981HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Coiled-coil domain-containing protein 11(CCDC11)
貨號：

CSB-BP856981HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Coiled-coil domain-containing protein 11(CCDC11)
貨號：

CSB-MP856981HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CFAP53
Uniprot No.：

Q96M91
別名：

4933415I03Rik; CCD11_HUMAN; CCDC11; Cilia and flagella associated protein 53; Coiled coil domain containing 11; Coiled coil domain containing protein 11; Coiled-coil domain-containing protein 11; FLJ32743; HTX6; MGC117752; RGD1306734
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-514
氨基酸序列

MYSQRFGTVQ REVKGPTPKV VIVRSKPPKG QGAEHHLERI RRSHQKHNAI LASIKSSERD RLKAEWDQHN DCKILDSLVR ARIKDAVQGF IINIEERRNK LRELLALEEN EYFTEMQLKK ETIEEKKDRM REKTKLLKEK NEKERQDFVA EKLDQQFRER CEELRVELLS IHQKKVCEER KAQIAFNEEL SRQKLVEEQM FSKLWEEDRL AKEKREAQEA RRQKELMENT RLGLNAQITS IKAQRQATQL LKEEEARLVE SNNAQIKHEN EQDMLKKQKA KQETRTILQK ALQERIEHIQ QEYRDEQDLN MKLVQRALQD LQEEADKKKQ KREDMIREQK IYHKYLAQRR EEEKAQEKEF DRILEEDKAK KLAEKDKELR LEKEARRQLV DEVMCTRKLQ VQEKLQREAK EQEERAMEQK HINESLKELN CEEKENFARR QRLAQEYRKQ LQMQIAYQQQ SQEAEKEEKR REFEAGVAAN KMCLDKVQEV LSTHQVLPQN IHPMRKACPS KLPP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.
基因功能參考文獻：
1. CCDC11 is a cilium-associated gene with a role in left-right patterning in Xenopus and in laterality disorders in humans PMID: 28621423
2. Cfap53 is a conserved regulator of organ laterality in both humans and zebrafish. PMID: 26531781
3. CCDC11 has a conserved essential function in cilia of the vertebrate left-right organizer during embryogenesis. PMID: 25504577
4. The authors suggest that CCDC11 is associated with autosomal recessive laterality defects of diverse phenotype resulting in SIT in one individual family member who is otherwise healthy, and in complex laterality anomalies (HS) in another member. PMID: 22577226
相關疾病：

Heterotaxy, visceral, 6, autosomal (HTX6)
亞細胞定位：

Cell projection, cilium.
蛋白家族：

CFAP53 family
組織特異性：

Expressed in skin fibroblasts (at protein level).
數據庫鏈接：

HGNC: 26530

OMIM: 614759

KEGG: hsa:220136

STRING: 9606.ENSP00000381553

UniGene: Hs.658630