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  4. Recombinant Human Codanin-1 (CDAN1), partial

Recombinant Human Codanin-1 (CDAN1), partial

  • 中文名稱：
    Recombinant Human Codanin-1(CDAN1) ,partial
  • 貨號：
    CSB-YP810285HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Codanin-1(CDAN1) ,partial
  • 貨號：
    CSB-EP810285HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Codanin-1(CDAN1) ,partial
  • 貨號：
    CSB-EP810285HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Codanin-1(CDAN1) ,partial
  • 貨號：
    CSB-BP810285HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Codanin-1(CDAN1) ,partial
  • 貨號：
    CSB-MP810285HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CDAN1
  • Uniprot No.：
  • 別名：
    CDA1; CDAI; CDAN1; CDAN1_HUMAN; Codanin; Codanin-1; Codanin1; PRO1295
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May act as a negative regulator of ASF1 in chromatin assembly.
  • 基因功能參考文獻：
    1. Mutation in CDAN1 gene is associated with congenital dyserythropoietic anemia. PMID: 29031773
    2. The missense substitution in CDAN1, C15ORF41, encodes a novel restriction endonuclease in congenital dyserythropoietic anemia type I. PMID: 23716552
    3. The proband with congenital dyserythropoietic anemia Iota in the first family was a compound heterozygote of CDAN1 with mutation IVS-12+2T>C and c. 3389C>T. PMID: 24196372
    4. The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. PMID: 22407294
    5. A link between mutant codanin-1 and the aberrant localization of HP1 alpha is supported by the finding that codanin-1 can be coimmunoprecipitated by anti-HP1 alpha antibodies erythroblasts from patients with congenital dyserythropoietic anemia type 1. PMID: 21364188
    6. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1 PMID: 12434312
    7. codanin-1 may play a role in the development of the skeleton. PMID: 16767397
    8. This second case of retinal angioid streaks in CDA I reports a patient homozygous for the Arg1042Trp mutation in codanin-1. PMID: 18081704
    9. Congenital dyserythropoietic anemia I (CDA I) is a well-defined entity within the heterogeneous group of the CDAN1 family; here it is associated with mutations in a Chinese family. PMID: 18575862
    10. Data suggest that codanin-1 is a cell cycle-regulated protein active in the S phase. PMID: 19336738

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  • 相關疾?。?/div>
    Anemia, congenital dyserythropoietic, 1A (CDAN1A)
  • 亞細胞定位：
    Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.
  • 組織特異性：
    Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
  • 數據庫鏈接：

    HGNC: 1713

    OMIM: 224120

    KEGG: hsa:146059

    STRING: 9606.ENSP00000348564

    UniGene: Hs.599232



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