在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cocaine esterase (CES2)

  • 中文名稱:
    Recombinant Human Cocaine esterase (CES2)
  • 貨號:
    CSB-YP005259HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Carboxylesterase 2;CE-2;hCE-2;Methylumbelliferyl-acetate deacetylase 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Yeast
  • 分子量:
    60.5 kDa
  • 表達區域:
    27-559aa
  • 氨基酸序列
    QDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins.
  • 基因功能參考文獻:
    1. SNPs in CDA and CES2 were associated with benefit from the addition of capecitabine to chemotherapy in metastatic breast cancer patients. PMID: 28827188
    2. Results revealed that most of the colorectal cancer specimens showed a considerable reduction in CES2 expression compared with adjacent normal tissue independently of p53. PMID: 29651325
    3. Anordrin is predominantly catalyzed by CES1 and CES2 to generate the main active metabolite, anordiol. PMID: 28532270
    4. These data suggest that infants younger than 3 weeks of age would exhibit significantly lower CES1- and CES2-dependent metabolic clearance compared with older individuals. PMID: 26825642
    5. Carboxylesterase 2 possesses triglyceride and diacylglycerol lipase activities and displayed an inverse correlation with HOMA-IR and hepatic diacylglycerol concentrations in humans. PMID: 28099843
    6. has triglyceride hydrolase activity; as a result, gain of hepatic CES2 function increases fatty acid oxidation and inhibits lipogenesis, whereas loss of hepatic CES2 stimulates lipogenesis by inducing endoplasmic reticulum stress PMID: 26806650
    7. Plasma cells are strong producers of CES-2 in intestinal inflammation and cancer and may be involved in metabolic activation of ester-containing prodrugs. PMID: 27149931
    8. Data show that carboxylesterase 2 (CES2A1) is the primary mediator of carboxylesterase (CES) substrates in the enterocytes. PMID: 28285137
    9. Findings suggest that CES2 expression and activity, by mediating the intratumoral activation of irinotecan, is a contributor to FOLFIRINOX sensitivity in pancreatic cancer. PMID: 26025324
    10. In the liver and duodenum, CES2 mRNA expression increased and exhibited a postnatal surge. PMID: 25724353
    11. After oral administration of dabigatran etexilate to humans, DABE is hydrolyzed by intestinal CES2 to the intermediate M2 metabolite followed by hydrolysis of M2 to DAB in the liver by CES1. PMID: 24212379
    12. expression of CES2, UGTA1A1, and GUSB varies in colorectal pathology tissues and that the expression of CES2 is somewhat related to tumor staging. PMID: 24195516
    13. Variations in CES2 in the promoter region, may alter rifampicin metabolism by affecting expression of the gene PMID: 23471941
    14. CES2 RNA expression was observed in neuroblastoma cells, and its expression in neuroblastoma cell lines was positively correlated with sensitivity to CPT-11 and apoptosis after CPT-11 exposure in vitro PMID: 23480903
    15. tested the hypothesis that an individual's CES phenotype can be characterized by reporter substrates/probes that interrogate native CES1 and CES2 activities in liver and immunoblotting methods PMID: 22525521
    16. Report CES2 mediated hydrolysis of heroin, cocaine and CPT-11. PMID: 20649590
    17. A comparison of the substrate specificity of CES1 versus CES2 reveals broad but distinct substrate preferences. PMID: 19508181
    18. The multiple promoters in the CES2 gene were characterized. PMID: 12835618
    19. Single-nucleotide polymorphism in carboxylesterase 2 is associated with reduced mRNA expression in colorectal tumors PMID: 15475243
    20. analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene PMID: 15475733
    21. human carboxylesterase 2 gene presents several polymorphisms, none of which seems to be involved in significant variations in protein activity PMID: 15592324
    22. TFF-1 is lost late in the progression from Barrett's Esophagus to adenocarcinoma, while CES-2 is upregulated PMID: 15967118
    23. in diffuse large B-cell lymphoma, molecular alterations in ice, bcl-2, c-myc and p53 are present in hematopoietic cells from bone marrow as well as in primitive hematopoietic progenitors PMID: 16690525
    24. p53 directly regulates CES-2 expression in a colonic cancer cell line. PMID: 16963839
    25. 830C>G single nucleotide polymorphism of CES2 is unlikely to have significant functional consequences on CES2 expression, activity or function PMID: 17483951
    26. IL-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of CES2. PMID: 17537833
    27. In a Japanese population, CES2 haplotypes and a defective allele were associated with a decrease in enzyme levels or activity. Pharmacokinetics of irinotecan was evaluated in cancer patients. PMID: 17640957
    28. comparative analysis of CES1 and CES2 in liver and small intestine of humans, monkeys, dogs, rabbits and rats PMID: 17764701
    29. Carboxylesterase 2 is downregulated in colorectal cancer following progression of the disease PMID: 18259949
    30. Carboxylesterase 1A2 has been isolated and determined to be identical to carboxylesterase 1A1 except for exon 1 and the 5' regulatory element. PMID: 18305377
    31. an association between a polymorphism in the CES2 gene and the efficacy of capecitabine has been described PMID: 18473752
    32. pharmacogenomic characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes PMID: 18794728
    33. Carboxylesterases play critical roles in drug metabolism and insecticide detoxication; findings show large variability among different age groups or even within the same age group. PMID: 18983829
    34. serum carboxylesterase-2 level might be a potential marker in the diagnosis of the early stage ovarian cancer. PMID: 19856659

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 蛋白家族:
    Type-B carboxylesterase/lipase family
  • 組織特異性:
    Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
  • 數據庫鏈接:

    HGNC: 1864

    OMIM: 605278

    KEGG: hsa:8824

    STRING: 9606.ENSP00000317842

    UniGene: Hs.282975



主站蜘蛛池模板: 一本到中文无码av在线精品| 欧美综合区自拍亚洲综合绿色| 免费人成再在线观看视频| 视频久re精品在线观看| 亚洲欧美日韩一区二区| 人人插人人插人人爽| 久久综合九色欧美综合狠狠| 亚洲性色av一区二区三区| 中文亚洲无线码49vv| 无人区一码卡二卡三乱码| 国产佗精品一区二区三区| 亚洲色婷婷久久精品av蜜桃| 欲求不满邻居的爆乳在线播放| 西西艺术人像摄影| 国产手机在线无码播放视频| 亚洲综合色成在线播放| 色综合99久久久无码国产精品| 亚洲国产最大av| 亚洲精品无码乱码成人| 把女邻居弄到潮喷的性经历| 人妻精品无码一区二区三区 | 国产无遮挡乱子伦免费精品| 欧洲一卡2卡3卡4卡乱码视频| 日韩电影一区二区三区| 四虎影视成人永久免费观看视频| 午夜影视啪啪免费体验区入口| 国产av影片麻豆精品传媒| 又色又爽又黄高潮的免费视频| 情侣做性视频在线播放| 国产精品爆乳在线播放第一人称| 欧美色欧美亚洲高清在线观看| 国产高潮流白浆视频| 内射人妻少妇无码一本一道| 在线视频免费观看爽爽爽| 久久亚洲精品高潮综合色a片| 久久精品成人免费观看97| 大香伊人久久精品一区二区| 亚洲精品成人久久久| 亚洲综合av色婷婷| 国产免费久久精品99reswag| 亚洲精品www久久久|