在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Coactosin-like protein (COTL1)

  • 中文名稱:
    Recombinant Human Coactosin-like protein(COTL1)
  • 貨號:
    CSB-EP622751HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    COTL1
  • Uniprot No.:
  • 別名:
    CLP; Coactosin like 1; Coactosin-like protein; COTL1; COTL1_HUMAN; FLJ43657; MGC19733
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    31.8kDa
  • 表達區域:
    2-142aa
  • 氨基酸序列
    ATKIDKEACRAAYNLVRDDGSAVIWVTFKYDGSTIVPGEQGAEYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSELKKAGGANYDAQTE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
  • 基因功能參考文獻:
    1. Study uncovers a novel tumor-suppressor role for CLP/Cotl1 and identify the downstream effectors interleukin 24 (IL-24)/PERP and IL-24/MAPK/ERK/TGF-beta. PMID: 28925397
    2. our combined results elucidated genetic and epigenetic silencing of miR-506-3p enhances COTL1 oncogene expression to foster NSCLC progression. PMID: 27893417
    3. The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied. PMID: 25034252
    4. COTL1 regulates lamellipodia dynamics in part by protecting F-actin from cofilin-mediated disassembly. PMID: 24454796
    5. PAI-RBP1 and C1orf142 expression levels are higher in 95D (high metastatic potential) than in 95C (low metastatic potential) non-small lung cancer cells, whereas COTL1 expression level is lower in 95D when compared to 95C cells. PMID: 22373659
    6. Up-regulated COTL-1 expression in small cell lung cancer was validated by Western blot analysis, immunohistochemistry, and qRT-qPCR. PMID: 21047053
    7. Results of the present study support a role for CLP as a chaperoning scaffold factor, influencing both the stability and the activity of 5-LO. PMID: 19807693
    8. CLP 57-65 peptide elicits immediate-type hypersensitivity. Identical peptides are recognized by cellular and humoral immune systems to a tumor-associated antigen. CLP 15-24 and 104-113 might be used for peptide-based immunotherapy of HLA-A2(+) cancers. PMID: 11870627
    9. NMR resonance assignments and the secondary structures of human Coactosin like protein (hCLP) D123N PMID: 15213466
    10. coactosin-like protein (CLP) is an actin-binding protein as well as a 5-lipoxygenase binding partner PMID: 15333945
    11. structural analysis shows that CLP forms a polymer along the crystallographic b axis with the exact same repeat distance as F-actin; a model for the CLP polymer and F-actin binding has therefore been proposed. PMID: 15459340
    12. preliminary crystallographic studies of human coactosin-like protein (CLP) PMID: 15583396
    13. Coactosin-like protein (CLP) up-regulates Ca(2+)-induced 5-lipoxygenase (5LO) activity, and increases the amount of Leukotriene A(4) formed by 5LO. PMID: 16924104
    14. extended region of beta4-beta5 of hCLP (residue 66-75) was found very flexible and very important for F-actin binding. The C-terminal residues of human coactosin-like protein were not involved in F-actin binding PMID: 17070122
    15. We found that coactosin-like1 (COTL1) were highly expressed in rheumatoid arthritis patients compared with healthy controls PMID: 19307756

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
  • 蛋白家族:
    Actin-binding proteins ADF family, Coactosin subfamily
  • 組織特異性:
    Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
  • 數據庫鏈接:

    HGNC: 18304

    OMIM: 606748

    KEGG: hsa:23406

    STRING: 9606.ENSP00000262428

    UniGene: Hs.289092



主站蜘蛛池模板: 亚洲毛片多多影院| 久久精品2021国产| 日本久久高清一区二区三区毛片| 精品无人区麻豆乱码1区2区| 中文字幕人妻丝袜二区| 国产人久久人人人人爽| 隔壁老王国产在线精品| 97精品国自产在线偷拍| 免费天堂无码人妻成人av电影| 亚洲成a人v欧美综合天堂麻豆| 日本少妇被黑人xxxxx| 日韩精品无码免费专区午夜不卡| 久久99久久99久久综合| 久久精品久久精品久久39| 亚洲日韩av无码中文字幕美国| 一本大道久久东京热av| 亚洲色无码中文字幕在线| 日韩高清国产一区在线| 中文天堂在线www| 亚洲热无码av一区二区东京热av| 久久久国产精品无码一区二区| 波多野结衣免费一区视频| 337p粉嫩大胆色噜噜噜| 水蜜桃av无码| 97人妻免费公开在线视频| 欧美视频专区一二在线观看| 久久久无码一区二区三区| 51社区精品视频| 永久中文字幕免费视频网站| 自拍偷自拍亚洲精品播放| 久久综合久久鬼色| 2020精品国产视| 麻花传媒mv国产免费观看视频 | 大帝a∨无码视频在线播放| 国内精品九九久久精品| 精品无码av无码专区| 国产精品无码永久免费888| 内射精品无码中文字幕| 国产亚洲精品久久久久秋霞| 男女下面一进一出好爽视频| 国产成人不卡无码免费视频|