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  4. Recombinant Human Class E basic helix-loop-helix protein 41 (BHLHE41)

Recombinant Human Class E basic helix-loop-helix protein 41 (BHLHE41)

  • 中文名稱：
    Recombinant Human Class E basic helix-loop-helix protein 41(BHLHE41)
  • 貨號：
    CSB-YP883658HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Class E basic helix-loop-helix protein 41(BHLHE41)
  • 貨號：
    CSB-EP883658HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Class E basic helix-loop-helix protein 41(BHLHE41)
  • 貨號：
    CSB-EP883658HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Class E basic helix-loop-helix protein 41(BHLHE41)
  • 貨號：
    CSB-BP883658HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Class E basic helix-loop-helix protein 41(BHLHE41)
  • 貨號：
    CSB-MP883658HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    BHLHE41
  • Uniprot No.：
  • 別名：
    Basic helix-loop-helix domain containing class B3; BHE41_HUMAN; bHLH protein DEC2; bHLHB3; bHLHe41; Class B basic helix loop helix protein 3; Class B basic helix-loop-helix protein 3; Class E basic helix-loop-helix protein 41; DEC2; Differentially expressed in chondrocytes protein 2; Enhancer of split and hairy related protein 1; Enhancer-of-split and hairy-related protein 1; hDEC2; Moderately similar to basic-helix loop helix protein M.musculus; SHARP-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-482
  • 氨基酸序列
    MDEGIPHLQE RQLLEHRDFI GLDYSSLYMC KPKRSMKRDD TKDTYKLPHR LIEKKRRDRI NECIAQLKDL LPEHLKLTTL GHLEKAVVLE LTLKHLKALT ALTEQQHQKI IALQNGERSL KSPIQSDLDA FHSGFQTCAK EVLQYLSRFE SWTPREPRCV QLINHLHAVA TQFLPTPQLL TQQVPLSKGT GAPSAAGSAA APCLERAGQK LEPLAYCVPV IQRTQPSAEL AAENDTDTDS GYGGEAEARP DREKGKGAGA SRVTIKQEPP GEDSPAPKRM KLDSRGGGSG GGPGGGAAAA AAALLGPDPA AAAALLRPDA ALLSSLVAFG GGGGAPFPQP AAAAAPFCLP FCFLSPSAAA AYVQPFLDKS GLEKYLYPAA AAAPFPLLYP GIPAPAAAAA AAAAAAAAAA AFPCLSSVLS PPPEKAGAAA ATLLPHEVAP LGAPHPQHPH GRTHLPFAGP REPGNPESSA QEDPSQPGKE AP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11.
  • 基因功能參考文獻：
    1. We validated DEC2 gene as a direct target of miR-873 which could reverse the repressive effects of miR-873 on esophageal cancer cell. PMID: 29890466
    2. Knockdown of DEC2 resulted in a significant (26.7%) reduction of VEGF expression in MIO-M1 cells under hypoxia-mimicking conditions induced by DFO (P < .05). Levels of HIF1alpha protein were also reduced significantly, by 60.2%, in MIO-M1 cells treated with siRNA against the DEC2 gene (P < .05). Moreover, HIF1alpha levels showed a significant (2.5-fold) increase in MIO-M1 cells overexpressing DEC2 (P < .05). PMID: 30250985
    3. Mutation in DCE2 gene is associated with short sleep behavioral trait. PMID: 29531056
    4. It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. PMID: 27384883
    5. venous levels lower in preeclampsia than in normal pregnancy PMID: 27845885
    6. The renal cell cancers associated polymorphic HIF-binding site at chromosome 12p12.1 regulates BHLHE41 expression. PMID: 28715484
    7. Findings suggest that basic helix-loop-helix family, member e41 protein (DEC2) suppresses cell cycle progression of the mesenchymal cells. PMID: 27430159
    8. DEC1, at least partly, exerted a pro-apoptotic effect, whereas DEC2 exerted an anti-apoptotic effect in paclitaxel-induced apoptosis of human prostate cancer cells. PMID: 27840924
    9. the present study indicated that SHARP1 acts as a tumor suppressor in thyroid cancer and that its downregulation may contribute to the proliferation, migration and invasion of thyroid cancer cells through mechanisms possibly involving HIF1alpha PMID: 27121679
    10. Study found that DEC2 was a direct target of miR-138. PMID: 27095063
    11. DEC2 is aberrantly expressed in rheumatoid arthritis tissue, it is induced by TNFalpha and not only affects the expression of genes belonging to molecular clock but also significantly impacts on the expression of IL-1beta as well as other inflammatory genes. PMID: 26710124
    12. BHLHE40/41 are promising markers to predict the aggressiveness of each Endometrial Neoplasm case and that molecular targeting strategies involving BHLHE40/41 and SP1 may effectively regulate Endometrial Neoplasm progression. PMID: 26391953
    13. DEC2 facilitates HIF-1alpha stabilization and promotes HIF-1 activation in osteosarcoma. PMID: 25884381
    14. DEC2 participates in hypoxia-induced cell proliferation by functioning as a target gene of the PI3K/Akt signaling pathway and regulating the expression of c-Myc. PMID: 25524285
    15. SHARP1 interacted with HIF-1alpha physically. PMID: 24918449
    16. Data suggest that SHARP1 plays a critical role in tumorigenesis and acquisition of the metastatic phenotype in endometrial cancer. PMID: 24997474
    17. DEC2 regulates cellular function by modulating the expression of Twist1 PMID: 25446074
    18. BHLHE41 mutations reduce total sleep while maintaining NREM sleep and provide resistance to the effects of sleep loss; mutations that affect sleep also modify the normal inhibition of BHLHE41 of CLOCK/BMAL1 transactivation PMID: 25083013
    19. we find high frequency of RAS mutations in t(6;11)(q27;q23) pediatric AML and are the first to report a unique and significant differential overexpression of BHLHB3 in these patients. PMID: 24561520
    20. GLI1 expression was immunohistochemically related positively with BHLHE41 and inversely with MLH1 in PDAC cells and precancerous lesions of the pancreas. PMID: 24165159
    21. Sumoylation of Sharp-1 exerts an impact on chromatin structure and transcriptional repression of muscle gene expression through recruitment of G9a. PMID: 23637228
    22. DEC2 regulates apoptosis in oral cancer cells via regulation of pro-apoptotic factor Bim expression PMID: 22572381
    23. SHARP1 is required, and sufficient, to limit expression of HIF-target genes PMID: 22801492
    24. results suggest that DEC2 periodically represses the promoter activity of CYP2D6, resulting in its circadian expression in serum-shocked cells PMID: 22355045
    25. DEC2 has anti-apoptotic effects on the paclitaxel-induced apoptosis in human breast cancer MCF-7 cells. PMID: 21327324
    26. demonstrated DEC2 expression in response to the treatment with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, in cultured human mesangial cells PMID: 21129405
    27. a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes PMID: 16287852
    28. DEC1 and DEC2 may play a crucial role in the adaptation to hypoxia PMID: 12354771
    29. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. [dec1] PMID: 12397359
    30. DEC1-mediated repression on the expression of DEC2 PMID: 12624110
    31. role of the BHLHB3 protein as a tumor suppressor for lung cancer. PMID: 18223678
    32. MLH1 is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. PMID: 18345027
    33. DEC1, along with DEC2, plays a role in the finer regulation and robustness of the molecular clock CLOCK/BMAL1 PMID: 18411297
    34. study identified a mutation, P385R, in DEC2 associated with a short sleep phenotype; activity profiles & sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice PMID: 19679812

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16617

    OMIM: 606200

    KEGG: hsa:79365

    STRING: 9606.ENSP00000242728

    UniGene: Hs.177841



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