在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Citrate synthase, mitochondrial (CS)

Recombinant Human Citrate synthase, mitochondrial (CS)

  • 中文名稱：
    Recombinant Human Citrate synthase, mitochondrial(CS)
  • 貨號：
    CSB-YP006031HU(A4)
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Citrate synthase, mitochondrial(CS)
  • 貨號：
    CSB-EP006031HU(A4)-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Citrate synthase, mitochondrial(CS)
  • 貨號：
    CSB-BP006031HU(A4)
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Citrate synthase, mitochondrial(CS)
  • 貨號：
    CSB-MP006031HU(A4)
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CISY_HUMAN; Citrate synthase; Citrate synthase; mitochondrial; citrate synthetase; Cs; EC 2.3.3; EC 2.3.3.1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    28-466
  • 氨基酸序列
    ASS TNLKDILADL IPKEQARIKT FRQQHGKTVV GQITVDMMYG GMRGMKGLVY ETSVLDPDEG IRFRGFSIPE CQKLLPKAKG GEEPLPEGLF WLLVTGHIPT EEQVSWLSKE WAKRAALPSH VVTMLDNFPT NLHPMSQLSA AVTALNSESN FARAYAQGIS RTKYWELIYE DSMDLIAKLP CVAAKIYRNL YREGSGIGAI DSNLDWSHNF TNMLGYTDHQ FTELTRLYLT IHSDHEGGNV SAHTSHLVGS ALSDPYLSFA AAMNGLAGPL HGLANQEVLV WLTQLQKEVG KDVSDEKLRD YIWNTLNSGR VVPGYGHAVL RKTDPRYTCQ REFALKHLPN DPMFKLVAQL YKIVPNVLLE QGKAKNPWPN VDAHSGVLLQ YYGMTEMNYY TVLFGVSRAL GVLAQLIWSR ALGFPLERPK SMSTEGLMKF VDSKSG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. citrate synthase and ACSS1 have tumorigenic functions in hepatocellular carcinoma PMID: 27363021
    2. Citrate synthase activity was lower in patients with heart failure with preserved ejection fraction compared to controls. PMID: 27179829
    3. mir-122 and its targets G6PC3, ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers. PMID: 27793029
    4. METTL12 methylates CS on Lys-395, which is localized in the CS active site. Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate. PMID: 28887308
    5. Data suggest that METTL12, localized in mitochondrial matrix, modifies/methylates Lys368 of citrate synthase in external surface region close to its catalytic site; addition/removal of methylation has no effect on citrate synthase activity; Lys368 occurs in highly conserved sequence of amino acid residues of citrate synthase. (METTL12 = methyltransferase-like protein 12) PMID: 28391595
    6. Data suggest that downregulation of citrate synthase (CS) expression in 293T cells leads to low level of ATP production, excessive superoxide formation and cell apoptosis, which implies a possible mechanism for hearing loss in A/J mice. PMID: 28216161
    7. Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities. PMID: 28161643
    8. Paretic muscle in hemiparetic stroke survivors had lower CS concentration. PMID: 26361074
    9. The citrate synthase knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production, but great increases in glycolytic metabolism. PMID: 23139858
    10. Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression. PMID: 22485150
    11. Responses of skeletal and cardiac muscles in CS activity and gene expression at 1 and 48 h after endurance training. Acute effect of exercise on training-induced elevation in CS activity in rat soleus but not ventricle muscles. PMID: 12531911
    12. possible role of CS-specific autoantibodies in the pathomechanism of allograft vasculopathy PMID: 15711981
    13. It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis. PMID: 15714131
    14. These results provide an important basis for the study of mitochondrial dysfunction due to aberrant CSa trafficking. PMID: 19479947

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Citrate synthase family
  • 數據庫鏈接：

    HGNC: 2422

    OMIM: 118950

    KEGG: hsa:1431

    STRING: 9606.ENSP00000342056

    UniGene: Hs.743252



主站蜘蛛池模板： 欧美牲交视频免费观看| 欧美高清精品一区二区| 国产精品亚洲五月天高清| 国产一区二区亚洲精品| 男女18禁啪啪无遮挡激烈网站 | 少妇高潮喷水久久久久久久久久| 看全色黄大色大片免费久久| 国产精品人成视频国模| 久久se精品一区二区三区| 天堂资源中文| 韩国理伦片一区二区三区在线播放| 青青草av一区二区三区| 日日日日做夜夜夜夜做无码| 国产在线精品一区在线观看| 97人人模人人爽人人少妇| 色天天天综合色天天| 性一交一乱一伦一| 人妻丰满熟妇av无码区app| av色欲无码人妻中文字幕| 人与狗精品aa毛片| 久久精品国产久精国产爱| 屁屁影院ccyy备用地址| 米奇影视第四色| 日本少妇xxx做受| 国产日产高清欧美一区| 无码国产69精品久久久久孕妇| 乱人伦人妻中文字幕无码久久网 | 国产肥熟女视频一区二区三区| 亚洲欧美国产双大乳头| 亚洲精品国产av现线| 色橹橹欧美在线观看视频高清| 精品无码人妻一区二区三区品| 蜜臀av色欲a片无码一区| 伊人久久大香线蕉无码| 久久www免费人成精品| 成人无码男男gv在线观看网站| 玩弄放荡人妻少妇系列| 国产成人av一区二区三区| 精品熟女少妇a∨免费久久| 日99久9在线 | 免费| 扒开女人内裤猛进猛出免费视频|