在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ciliary neurotrophic factor receptor subunit alpha (CNTFR)

Recombinant Human Ciliary neurotrophic factor receptor subunit alpha (CNTFR)

  • 中文名稱：
    Recombinant Human Ciliary neurotrophic factor receptor subunit alpha(CNTFR)
  • 貨號：
    CSB-YP005684HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Ciliary neurotrophic factor receptor subunit alpha(CNTFR)
  • 貨號：
    CSB-EP005684HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Ciliary neurotrophic factor receptor subunit alpha(CNTFR)
  • 貨號：
    CSB-EP005684HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Ciliary neurotrophic factor receptor subunit alpha(CNTFR)
  • 貨號：
    CSB-BP005684HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ciliary neurotrophic factor receptor alpha; Ciliary neurotrophic factor receptor; Ciliary neurotrophic factor receptor subunit alpha; CNTF Receptor alpha; CNTF receptor subunit alpha; CNTFR Alpha; CNTFR; CNTFR-alpha; CNTFR_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    23-342
  • 氨基酸序列
    QRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1.
  • 基因功能參考文獻：
    1. The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder. PMID: 24565995
    2. gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. PMID: 23398366
    3. Data indicate that CNTFRalpha plays a role in the formation or maintenance of tumor-initiating cells in gliomas, is a marker that correlates with histological grade, may underlie treatment resistance in some cases, and is a potential therapeutic target. PMID: 23061382
    4. expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth. PMID: 22343487
    5. Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders. PMID: 20219210
    6. interactions of CNTFR with LIFR and gp130 in vitro PMID: 12707266
    7. C174T polymorphism in exon 9 of CNTFR is significantly associated with fat-free mass in men and women, with concomitant differences in muscular strength. PMID: 12807897
    8. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
    9. In liver CNTFRalpha serves as a key modulator in regulating PI3K and AMP-activated protein kinase dynamically under CNTF stimulation, resulting in the increase of glucose uptake and translocation of glucose transporter 4. PMID: 18307269
    10. These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Type I cytokine receptor family, Type 3 subfamily
  • 組織特異性：
    Nervous system and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2170

    OMIM: 118946

    KEGG: hsa:1271

    STRING: 9606.ENSP00000242338

    UniGene: Hs.129966



主站蜘蛛池模板： 亚洲国产欧美在线人成| 99久久国产亚洲高清观看| 亚洲国产精品无码专区影院| 国产精品久久久久久人妻精品动漫| 国产成人精品电影在线观看| 亚洲最新无码中文字幕久久| 羞羞视频在线观看| 色综合色狠狠天天综合网| 国产av影片麻豆精品传媒| 精品国产自在精品国产精华天| 色综合久久网| 巨爆乳无码视频在线观看| 一边捏奶头一边啪高潮视频| 日日噜噜大屁股熟妇| 亚洲一卡2卡3卡4卡精品 | 99大香伊乱码一区二区| 又色又爽又高潮免费视频观看| 无套内射视频囯产| a狠狠久久蜜臀婷色中文网| 亚洲精品1卡2卡三卡23卡| 国产成人久久精品77777综合| 人妻洗澡被强公日日澡| 亚洲色偷偷偷网站色偷一区 | 女人高潮内射99精品 | 最近中文字幕免费大全在线| 免费观看日本污污ww网站| 欧美大成色www永久网站婷| 醉酒后少妇被疯狂内射视频| 亚洲国产欧美在线成人app| 一本色道久久88加勒比—综合| 国产一区二区三区四区五区加勒比| 久久天天躁夜夜躁狠狠i女人 | 国产在线一区二区三区四区五区| 亚洲免费观看在线视频| 亚洲 自拍 另类小说综合图区| 亚洲旡码a∨一区二区三区| 精品免费国偷自产在线视频| 精品成人av一区二区三区| 天天做天天爱天天综合网| 内射小寡妇无码| 好男人社区影院www|