Recombinant Human Chromodomain-helicase-DNA-binding protein 6 (CHD6), partial

中文名稱：

Recombinant Human Chromodomain-helicase-DNA-binding protein 6(CHD6) ,partial
貨號：

CSB-YP851546HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Chromodomain-helicase-DNA-binding protein 6(CHD6) ,partial
貨號：

CSB-EP851546HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Chromodomain-helicase-DNA-binding protein 6(CHD6) ,partial
貨號：

CSB-EP851546HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Chromodomain-helicase-DNA-binding protein 6(CHD6) ,partial
貨號：

CSB-BP851546HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Chromodomain-helicase-DNA-binding protein 6(CHD6) ,partial
貨號：

CSB-MP851546HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CHD6
Uniprot No.：

Q8TD26
別名：

ATP dependent helicase CHD6; ATP-dependent helicase CHD6; CHD-6; CHD5; CHD6; CHD6_HUMAN; chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6; helicase C-terminal domain- and SNF2 N-terminal domain-containing protein; KIAA1335; Radiation induced gene B protein; Radiation-induced gene B protein; RIGB; RP4-620E11.2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.; (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.
基因功能參考文獻：
1. The role of CHD6 in regulating the chromatin topology of CFTR as an exemplary genetic model for this mechanism was described. PMID: 25631877
2. CHD6 regulates the topology of the CFTR locus PMID: 25631877
3. These data indicate that CHD6 degradation is a general effect exerted by influenza A viruses and suggest that this viral repressor may play an important inhibitory role since degradation and accumulation into inactive chromatin occur during the infection. PMID: 23408615
4. CHD6 has a negative role in the influenza virus cycle because the virus replicates more efficiently in CHD6-silenced cells. PMID: 21899694
5. Both RNA knockdown experiments and mutational analyses of the E2C domain suggest that binding of CHD6 to E8--E2C contributes to the transcriptional repression of the huma papillomavirus E6/E7 oncogene promoter. PMID: 20631145
6. CHD6 colocalizes with both hypo- and hyper-phosphorlylated forms of RNA polymerase II. CHD6 was found to be present at sites of mRNA synthesis and to be part of a high molecular weight complex. PMID: 17027977
7. Describes AY034072, the sequence of a gene whose original symbol, CHD5, has been changed to CHD6. PMID: 11889561
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相關疾?。?/div>
A chromosomal aberration disrupting CHD6 has been found in a patient with mild to moderate mental retardation and minor facial anomalies. Translocation t(18;20)(q21.1;q11.2) with TCF4 producing a CHD6-TCF4 fusion transcript (PubMed:18627065).
亞細胞定位：

Nucleus, nucleoplasm.
蛋白家族：

SNF2/RAD54 helicase family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 19057

OMIM: 616114

KEGG: hsa:84181

STRING: 9606.ENSP00000362330

UniGene: Hs.740645