在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Chromobox protein homolog 8 (CBX8)

In Stock
  • 貨號:
    CSB-EP864026HUa0
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    CBX8
  • Uniprot No.:
  • 別名:
    (Polycomb 3 homolog)(Pc3)(hPc3)(Rectachrome 1)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    49.4 kDa
  • 表達區域:
    1-389aa
  • 氨基酸序列
    MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
  • 基因功能參考文獻:
    1. CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma. PMID: 29066512
    2. CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis. PMID: 28912889
    3. The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients. PMID: 28837252
    4. CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis PMID: 27505670
    5. CBX8 plates roles in epigenetic regulation in DNA damage response. PMID: 27555324
    6. IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression PMID: 25398592
    7. The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues. PMID: 26837964
    8. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment. PMID: 26718407
    9. Low CBX8 expression was associated with distant metastasis in colorectal cancer. PMID: 25360999
    10. CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy. PMID: 25197352
    11. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics. PMID: 24460908
    12. Interaction with CBX8 precludes AF9-DOT1L binding. PMID: 23891621
    13. CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter. PMID: 23474493
    14. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. PMID: 22094252
    15. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions. PMID: 17332741

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 15962

    OMIM: 617354

    KEGG: hsa:57332

    STRING: 9606.ENSP00000269385

    UniGene: Hs.387258



主站蜘蛛池模板: 国产成人无码精品久久久免费 | 精品无人国产偷自产在线| 久久久久久九九99精品| 少妇特殊按摩高潮惨叫无码| 日本一道本高清一区二区| 欧美z0zo人禽交免费观看99| 久久av无码αv高潮αv喷吹| 久久人人爽人人爽人人爽| 免费看女人与善牲交| 777米奇色狠狠俺去啦奇米77| 免费无码一区二区三区a片百度 | 中文精品久久久久人妻| 狠狠亚洲色一日本高清色| 中文字幕无线观看中文字幕| 午夜精品久久久久久久无码| 久章草国语自产拍在线观看 | 少妇愉情理伦片丰满丰满| 亚洲国产果冻传媒av在线观看 | 亚洲精品专区成人网站| 西西人体大胆午夜视频| 欧美一区二区三区激情 | 久久er99国产精品免费| 射精区-区区三区| 亚洲精品一区二区久| 国产麻豆 9l 精品三级站| 男生白内裤自慰gv白袜男同| 久久综合九色综合97欧美| 无码高潮少妇毛多水多水免费| 日韩亚洲中字无码一区二区三区 | 99国产精品欧美一区二区三区| 污污内射在线观看一区二区少妇| 国产有奶水哺乳期无码avav| 人妻无码中文字幕永久在线 | 国产亚洲精品ae86| 亚洲精品久久国产高清小说| 综合亚洲另类欧美久久成人精品| 性一交一乱一色一视频| 无套内射chinesehd熟女| 亚洲 日本 欧美 中文幕| 啦啦啦中文在线观看日本| 亚洲欧美成人综合图区|