在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Charged multivesicular body protein 5 (CHMP5)

  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 5(CHMP5)
  • 貨號:
    CSB-YP878944HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 5(CHMP5)
  • 貨號:
    CSB-EP878944HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 5(CHMP5)
  • 貨號:
    CSB-BP878944HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 5(CHMP5)
  • 貨號:
    CSB-MP878944HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    apoptosis-related protein PNAS-2; C9orf83; CGI 34; Charged multivesicular body protein 5; CHMP 5; CHMP family; member 5; chmp5; CHMP5_HUMAN; Chromatin modifying protein 5; Chromatin-modifying protein 5; Chromosome 9 open reading frame 83; HGNC:26942; HSPC177; hVps60; PNAS 2; SNF7 domain containing protein 2; SNF7 domain-containing protein 2; SNF7DC2; Vacuolar protein sorting 60; Vacuolar protein sorting-associated protein 60; Vps60
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-219
  • 氨基酸序列
    MNRLFGKAKP KAPPPSLTDC IGTVDSRAES IDKKISRLDA ELVKYKDQIK KMREGPAKNM VKQKALRVLK QKRMYEQQRD NLAQQSFNME QANYTIQSLK DTKTTVDAMK LGVKEMKKAY KQVKIDQIED LQDQLEDMME DANEIQEALS RSYGTPELDE DDLEAELDAL GDELLADEDS SYLDEAASAP AIPEGVPTDT KNKDGVLVDE FGLPQIPAS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
  • 基因功能參考文獻:
    1. CHMP5 might be involved in the homeostatic regulation of TCR on the cell surface, presumably through TCR recycling or degradation. Thus CHMP5 is implicated in TCR-mediated signaling. PMID: 26821576
    2. ESCRT-III protein CHMP5 inhibits LIP5-mediated VPS4 activation by inducing a moderate conformational change within LIP5. PMID: 25637630
    3. after CHMP5 inhibition, both Granzyme B/Perforin apoptotic pathway and apoptosis-inducing factor-mediated necrotic pathway were activated, while autophagic pathway was not activated PMID: 23619569
    4. PNAS-2 was shown to be anti-apoptotic and may participate in leukemogenesis PMID: 17855796
    5. pnas-2 is specifically up-regulated in acute leukemia patients. PMID: 18426649
    6. The pnas-2 gene may be closely related with apotosis of arsenic sulfide treated APL cells. PMID: 17708794

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
  • 蛋白家族:
    SNF7 family
  • 數據庫鏈接:

    HGNC: 26942

    OMIM: 610900

    KEGG: hsa:51510

    STRING: 9606.ENSP00000223500

    UniGene: Hs.635313



主站蜘蛛池模板: 免费看成人午夜福利专区| 天天躁人人躁人人躁狂躁| 大胸少妇午夜三级| 午夜精品一区二区三区免费视频 | 中文字幕亚洲无线码| 免费看无码毛视频成片| 国产色播av在线观看| 天干天干夜啦天干天干国产| 亚洲精品av一区午夜福利| 日韩人妻精品无码一区二区三区| 亚洲国产av无码精品| 国产v亚洲v天堂无码久久久| 久久综合九色综合97网| 久久99日韩国产精品久久99| 无人区一码卡二卡三乱码| 日欧一片内射va在线影院| 色多多性虎精品无码av| 国内精品久久久久影院薰衣草| 欧美综合自拍亚洲综合区| 成熟老妇女毛茸茸的做性| 中文字幕人成无码人妻综合社区| 欧美日韩一区二区成人午夜电影| 无码精品久久久久久人妻中字| 日韩免费一区二区三区高清| 少妇的渴望hd高清在线播放| 国产av人人夜夜澡人人爽麻豆 | 丰满人妻熟妇乱又仑精品| 亚洲色成人网一二三区| 精品一区二区ww| av无码人妻无码男人的天堂| 国产成年无码久久久免费| 无码精品a∨在线观看中文| 18禁裸体女免费观看| 国产成人亚洲综合网色欲网| 2021年精品国产福利在线| 无码人妻h动漫中文字幕| 在线看片免费人成视频久网| 日本在线a一区视频| 东京热人妻丝袜av无码| 天美麻花果冻视频大全英文版 | 亚洲国产成人精品激情姿源 |