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Recombinant Human Ceruloplasmin (CP), partial

In Stock
  • 貨號(hào):
    CSB-EP005874HUa0
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    CP
  • Uniprot No.:
  • 別名:
    (Ferroxidase)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    32.1 kDa
  • 表達(dá)區(qū)域:
    807-1050aa
  • 氨基酸序列
    ILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense.
  • 基因功能參考文獻(xiàn):
    1. ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients PMID: 29127684
    2. Maternal blood ceruloplasmin level was found to be lower in neural tube defect-affected pregnancies as compared to healthy controls. PMID: 28397206
    3. Increased serum transferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes has been reported. PMID: 29079528
    4. Strong correlations between the meconium concentrations of CP, LF and MPO indicate a possible role of these complementary proteins in maintaining homeostasis of the intrauterine environment of the fetus. CP, LF and MPO measured in meconium may serve as biomarkers for assessment of impairment of oxidative balance during intrauterine life with its potential impact on disease development in adulthood. PMID: 27903408
    5. A woman in her 50s who initially presented with movement disorder was diagnosed with aceruloplasminemia, a rare autosomal recessive disorder resulting in accumulation of iron deposits in major organs. Genetic testing confirmed mutations in the ceruloplasmin gene (c.1864 + 1G>C). PMID: 27416276
    6. Higher circulating ceruloplasmin levels were associated with increased atrial fibrillation risk. PMID: 28427851
    7. for ATP7B mutations, the more severe impact on ATP7B protein was, the younger onset age and lower Cp level presented. The feasibility of presymptomatic DNA diagnosis and predicting clinical manifestation or severity of Wilson disease (WD) would be facilitated with identified mutations and genotype-phenotype correlation precisely revealed in the study. PMID: 27982432
    8. Ceruloplasmin is supposed to be related with advanced T stage and perineural invasion, having a possibility as a candidate prognostic marker for bile duct cancer. PMID: 28423673
    9. Mechanistically, ceruloplasmin could specifically interact with the hepatitis B virus middle surface protein. PMID: 28678687
    10. The present study determined that ARE, CLP, CAT, and MPO levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units. PMID: 28167245
    11. Ceruloplasmin was independently and negatively associated with liver fibrosis in chronic hepatitis b. PMID: 27920479
    12. Coronary atherosclerosis is distinguished by serum C4 complement up-regulation and ceruloplasmin down-regulation. PMID: 28091899
    13. Data show that the concentration of ceruloplasmin (ferroxidase; Cp) was significantly higher in Low hemoglobin (Hb) compared to High Hb subsample. PMID: 27235174
    14. serum ceruloplasmin level was lower in the primary open-angle glaucoma group in comparison to the group with only cataract. PMID: 27109647
    15. The determination of serum ceruloplasmin in adolescents might be a useful tool to identify patients with the highest risk of future cardiovascular disease. PMID: 27083758
    16. The main result of this study is that ceruloplasmin specific activity is associated with a decreased risk of developing Alzheimer's disease PMID: 26836154
    17. pathological cerebrospinal fluid's environment of Parkinson's disease patients promoted the same modifications in the exogenously added ceruloplasmin PMID: 26537957
    18. Homozygosity for c.1948G>A is described in a Dutch family with aceruloplasminemia. PMID: 25661792
    19. Cp-mediated neuroprotection occurs via the inhibition of seizure-associated oxidative damage. PMID: 25843655
    20. PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia PMID: 25490030
    21. results of this study suggest that common genetic variants of CP are associated with PD and further investigation is needed to explore their functions in Parkinson disease. PMID: 25758665
    22. we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers. PMID: 24676332
    23. sLe(x)/CP ratio tended to be higher for the pancreatic adenocarcinoma PMID: 25595436
    24. brain microvascular endothelial cell -secreted cytokine activity increases the gene expression of neighboring C6 glioma CP, which reciprocally acts on basolateral BMVEC ferroportin to enhance brain iron import PMID: 25311416
    25. High ceruloplasmin levels are associated with preeclampsia. PMID: 25463281
    26. Mercury metallation of the bacterial copper protein azurin is analogous to the one of human cerulopsmin and factor VIII in mercury poisoning. PMID: 25265377
    27. A reduced serum FeOx activity, which can potentially lead to a rise in oxidative stress-induced biomolecular damage, seems to be a shared condition in inflammatory disorders of the central nervous system including MS. PMID: 25398823
    28. This review describes the main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein) PMID: 24988611
    29. ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells PMID: 24533165
    30. The core-fucosylation ratio of ceruloplasmin increases significantly in alcohol-related hepatocellular carcinoma. PMID: 24799124
    31. In CKD patients, increased serum ceruloplasmin, a regulator of nitric oxide activity, is associated with increased risk of long-term adverse cardiovascular events, even after multivariable model adjustment for traditional clinical/biologic risk factors. PMID: 24311705
    32. Ceruloplasmin and gelsolin are closely interacted with the oncogene NF-kappab. PMID: 23925487
    33. Increased urinary excretion of plasma proteins such as IgG, ceruloplasmin and transferrin, with different molecular radii of 55 A or less and different isoelectric points precede development of microalbuminuria in patients with NIDDM and hypertension. PMID: 24256706
    34. The main result of this meta-analysis is that copper not bound to ceruloplasmin appears signi fi cantly increased in subjects with Alzheimer's disease when compared to healthy controls. PMID: 24072069
    35. CP levels correlate negatively and indirectly with inflammation and fibrosis stages in male chronic hepatitis B patients. PMID: 24282481
    36. both Cp NGR sites can deamidate during aging under oxidative conditions, likely as a consequence of oxidative-induced structural changes, thereby promoting a gain of function in integrin binding, signaling, and cell adhesion. PMID: 24366863
    37. Findings indicate a causal role of ceruloplasmin in AF pathophysiology and suggest that ceruloplasmin might be a mediator in a specific inflammatory pathway that causally links inflammatory diseases and incidence of Atrial Fibrillation (AF). PMID: 24118451
    38. A novel homozygous mutation of c.2185 delC in exon 12 was found in ceruloplasmin gene in a patient with aceruloplasminemia. PMID: 23812204
    39. Eosinophil activation occurred in early and late responses after L-ASA NPT in upper airway mucosa of AERD patients, where ApoA1, alpha2M and CP as well as CysLT may be involved in eosinophilic inflammation. PMID: 23786280
    40. The diffusion of an Fe(2+) ion from the inner opening of the human H-chain ferritin to a ferroxidase site located in the interior region of the protein coat is assisted by Thr135, His136 and Tyr137. PMID: 23344859
    41. Ceruloplasmin was significantly elevated in patients with ischemic or nonischemic cardiomyopathy and had linear correlation with C-reactive protein and LVEF PMID: 23781119
    42. Cp was associated with incident heart failure, mortality, and cardiovascular disease in the Atherosclerosis Risk in Communities population. PMID: 23861484
    43. Data suggest that ceruloplasmin (CP) level in serum decreases according to severity of pediatric nonalcoholic fatty liver disease (NAFLD); thus, serum CP may serve as biomarker to discriminate children with severe NAFLD. PMID: 23154483
    44. plasma ceruloplasmin is a potential plasma biomarker of aGvHD, and it also has prognostic value for risk-adapted prophylaxis. PMID: 23505556
    45. Iron efflux from human brain microvasculature endothelial cells ferroportin requires the action of an exocytoplasmic ferroxidase which can be either endogenous hephaestin or extracellular ceruloplasmin. PMID: 23640881
    46. study of effect of occupational exposure to lead among metallurgy workers in Poland on blood levels of transferrin (TRF), ceruloplasmin (CER) and haptoglobin (HPG): Data suggest that blood levels of copper and CER are raised with lead exposure. PMID: 22923205
    47. ceruloplasmin should provide a protective shield against inadvertent oxidant production by myeloperoxidase during inflammation PMID: 23306200
    48. Letter: report mutations in ceruloplasmin promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda. PMID: 23012398
    49. study to determine if genetic variations identified in CP gene contribute to oesophageal cancer (OC) pathogenesis or susceptibility in Black Xhosa-speaking South African population; statistically significant associations found for 2 of the novel variants with OC in this study and could potentially contribute to disease susceptibility PMID: 21901748
    50. change of the maintenance of three acute phase proteins: ceruloplasmin, alpha1-antitripsin and orosomucoid in an oral fluid and blood plasma at paradontitis and myocardial infarction PMID: 22708402

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  • 相關(guān)疾病:
    Aceruloplasminemia (ACERULOP)
  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Multicopper oxidase family
  • 組織特異性:
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2295

    OMIM: 117700

    KEGG: hsa:1356

    STRING: 9606.ENSP00000264613

    UniGene: Hs.558314



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