Recombinant Human Centriolin (CNTRL), partial

中文名稱：

Recombinant Human Centriolin(CNTRL) ,partial
貨號：

CSB-YP773804HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Centriolin(CNTRL) ,partial
貨號：

CSB-EP773804HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Centriolin(CNTRL) ,partial
貨號：

CSB-EP773804HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Centriolin(CNTRL) ,partial
貨號：

CSB-BP773804HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Centriolin(CNTRL) ,partial
貨號：

CSB-MP773804HU
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CNTRL
Uniprot No.：

Q7Z7A1
別名：

CNTRL; CEP1; CEP110Centriolin; Centrosomal protein 1; Centrosomal protein of 110 kDa; Cep110
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.
基因功能參考文獻：
1. CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models PMID: 23777766
2. CEP110 is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC. PMID: 11956314
3. We propose that centriolin anchors protein complexes required for vesicle targeting and fusion and integrates membrane-vesicle fusion with abscission. PMID: 16213214
相關疾?。?/div>
A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring.
組織特異性：

Widely expressed with highest levels in testis and trachea.
數據庫鏈接：

HGNC: 1858

OMIM: 605496

KEGG: hsa:11064

STRING: 9606.ENSP00000238341

UniGene: Hs.653263