在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Cell death regulator Aven (AVEN)

Recombinant Human Cell death regulator Aven (AVEN)

  • 中文名稱：
    Recombinant Human Cell death regulator Aven(AVEN)
  • 貨號：
    CSB-YP868289HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cell death regulator Aven(AVEN)
  • 貨號：
    CSB-EP868289HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cell death regulator Aven(AVEN)
  • 貨號：
    CSB-EP868289HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cell death regulator Aven(AVEN)
  • 貨號：
    CSB-BP868289HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cell death regulator Aven(AVEN)
  • 貨號：
    CSB-MP868289HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AVEN
  • Uniprot No.：
  • 別名：
    1700013A01Rik; 1700056A21Rik; Apoptosis caspase activation inhibitor; AVEN; AVEN_HUMAN; Cell death regulator Aven; mAven L; mAven S; MGC124011; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-362
  • 氨基酸序列
    MQAERGARGG RGRRPGRGRP GGDRHSERPG AAAAVARGGG GGGGGDGGGR RGRGRGRGFR GARGGRGGGG APRGSRREPG GWGAGASAPV EDDSDAETYG EENDEQGNYS KRKIVSNWDR YQDIEKEVNN ESGESQRGTD FSVLLSSAGD SFSQFRFAEE KEWDSEASCP KQNSAFYVDS ELLVRALQEL PLCLRLNVAA ELVQGTVPLE VPQVKPKRTD DGKGLGMQLK GPLGPGGRGP IFELKSVAAG CPVLLGKDNP SPGPSRDSQK PTSPLQSAGD HLEEELDLLL NLDAPIKEGD NILPDQTSQD LKSKEDGEVV QEEEVCAKPS VTEEKNMEPE QPSTSKNVTE EELEDWLDSM IS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Protects against apoptosis mediated by Apaf-1.
  • 基因功能參考文獻：
    1. AVEN and BIRC6 are inhibited by combination therapy of miR-30e and proanthocyanidin in glioblastoma stem cells PMID: 27388765
    2. The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
    3. the expression of Aven is regulated by the Akt signaling pathway through cathepsin D activity, which contributes to the sensitivity of cancer cells to chemotherapeutic agents. PMID: 25573060
    4. The findings implicate Aven in ATR-Chk1 signalling and point towards Chk1 inhibition as a strategy to sensitize human osteosarcomas to chemotherapy. PMID: 25757065
    5. Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. PMID: 22751129
    6. a model of Aven activation by which its N-terminal inhibitory domain is removed by CathD-mediated proteolysis, thereby unleashing its cytoprotective function. PMID: 22388353
    7. The results suggest that deregulation of the expression of the apoptosis inhibitor Aven may be related to male factor infertility. PMID: 21718987
    8. the expression level of aven mRNA in de novo AML patients obviously increases PMID: 20030919
    9. Results suggest that the regulation of Exportin-1/CRM1-dependent nucleocytoplasmatic traffic of Aven could modulate its ability to influence cell cycle progression. PMID: 20935510
    10. Aven expression was found to be higher in patients >or=10 years old or <1 year, and with unfavorable cytogenetic abnormalities. It was also significantly higher in relapsed patients in the standard-risk group and an independent poor prognostic factor. PMID: 16388850
    11. point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors PMID: 18303113
    12. These results identify Aven as a new ATM activator and describe a positive feedback loop operating between Aven and ATM; in aggregate, these findings place Aven, a known apoptotic inhibitor, as a critical transducer of the DNA-damage signal. PMID: 18571408

    顯示更多

    收起更多

  • 亞細胞定位：
    Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes.
  • 組織特異性：
    Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 13509

    OMIM: 605265

    KEGG: hsa:57099

    STRING: 9606.ENSP00000306822

    UniGene: Hs.555966



主站蜘蛛池模板： 日本欧美久久久久免费播放网 | 亚洲人成人77777网站| 亚洲乱妇老熟女爽到高潮的片| 国产精品无码一区二区在线| 久久久中文字幕日本无吗| 亚洲精品久久yy5099| 18禁超污无遮挡无码网址| 五 月 丁 香 综合中文| 好大好硬好爽免费视频| 日韩av无码免费播放| 国产肥熟女视频一区二区三区| 看成年全黄大色黄大片| 亚洲 日韩 国产 有码 不卡| 日本黄页网站免费大全| 国产亚洲一区二区在线观看| 蜜臀av99无码精品国产专区| 乱子伦农村xxxxbbb| 玩两个丰满老熟女| 天堂а√中文在线官网| 亚洲精品卡2卡3卡4卡5卡区| 国产精品a久久777777| 无码里番纯肉h在线网站| 久久人人爽人人爽人人片av麻烦| 饥渴少妇做私密保健视频| 国产精品女主播在线视频| 国产肉体xxxx裸体784大胆| 国产又粗又猛又大爽又黄| 97无码免费人妻超级碰碰夜夜| 久久精品人人做人人综合试看| 亚洲人成人网站在线观看| 成人内射国产免费观看| 窝窝午夜看片成人精品| 亚洲男人a在天堂线一区| 无码成人一区二区| 强辱丰满人妻hd中文字幕| 无码中文字幕va精品影院| 国产久久精品| 亚洲日韩av无码中文字幕美国| 中文字幕aav| 日韩一区二区三区四区区区| 性视频播放免费视频|