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  4. Recombinant Human Cation transport regulator-like protein 2 (CHAC2)

Recombinant Human Cation transport regulator-like protein 2 (CHAC2)

  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 2(CHAC2)
  • 貨號：
    CSB-YP845146HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 2(CHAC2)
  • 貨號：
    CSB-EP845146HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 2(CHAC2)
  • 貨號：
    CSB-EP845146HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 2(CHAC2)
  • 貨號：
    CSB-BP845146HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 2(CHAC2)
  • 貨號：
    CSB-MP845146HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CHAC2
  • Uniprot No.：
  • 別名：
    Cation transport regulator like protein 2; Cation transport regulator-like protein 2; ChaC; cation transport regulator homolog 2 (E. coli); chac2; CHAC2_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-184
  • 氨基酸序列
    MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV TLVEDPAGCV WGVAYRLPVG KEEEVKAYLD FREKGGYRTT TVIFYPKDPT TKPFSVLLYI GTCDNPDYLG PAPLEDIAEQ IFNAAGPSGR NTEYLFELAN SIRNLVPEEA DEHLFALEKL VKERLEGKQN LNCI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
  • 基因功能參考文獻：
    1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis. PMID: 29054545
    2. Results showed for the first time that CHAC2 was degraded by the ubiquitin-proteasome pathway and CHAC2 expression inhibited tumor cell growth, proliferation, migration in vitro and in vivo. Mechanistic study showed that CHAC2 induced mitochondrial apoptosis and autophagy through unfolded protein response. PMID: 28837156
    3. Human and mouse ChaC2 proteins purified in vitro show 10-20-fold lower catalytic efficiency than ChaC1, although they showed comparable Km values PMID: 27913623
  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Gamma-glutamylcyclotransferase family, ChaC subfamily
  • 數據庫鏈接：

    HGNC: 32363

    OMIM: 617446

    KEGG: hsa:494143

    STRING: 9606.ENSP00000295304

    UniGene: Hs.585944



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