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  4. Recombinant Human Cardiomyopathy-associated protein 5 (CMYA5), partial

Recombinant Human Cardiomyopathy-associated protein 5 (CMYA5), partial

  • 中文名稱：
    Recombinant Human Cardiomyopathy-associated protein 5(CMYA5) ,partial
  • 貨號(hào)：
    CSB-YP843149HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cardiomyopathy-associated protein 5(CMYA5) ,partial
  • 貨號(hào)：
    CSB-EP843149HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cardiomyopathy-associated protein 5(CMYA5) ,partial
  • 貨號(hào)：
    CSB-EP843149HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cardiomyopathy-associated protein 5(CMYA5) ,partial
  • 貨號(hào)：
    CSB-BP843149HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cardiomyopathy-associated protein 5(CMYA5) ,partial
  • 貨號(hào)：
    CSB-MP843149HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CMYA5
  • Uniprot No.：
  • 別名：
    2310076E16Rik; C5orf10; Cardiomyopathy associated 5; Cardiomyopathy associated protein 5; Cardiomyopathy-associated protein 5; Chromosome 5 open reading frame 10; CMYA 5; Cmya5; CMYA5_HUMAN; DKFZp451G182; DKFZp451G223; DTNBP2; Dystrobrevin binding protein 2; Dystrobrevin-binding protein 2; Genethonin 3; Genethonin-3; Myospryn; SPRY domain containing protein 2; SPRY domain-containing protein 2; SPRYD2; TRIM76; Tripartite motif containing 76; Tripartite motif containing protein 76; Tripartite motif-containing protein 76
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A. May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration. Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle.
  • 基因功能參考文獻(xiàn)：
    1. The results showed that MYBPC3 25-bp deletion polymorphism was significantly associated with elevated risk of left ventricular dysfunction (LVD), while TTN 18 bp I/D, TNNT2 5 bp I/D and myospryn K2906N polymorphisms did not show any significant association with LVD. PMID: 27350668
    2. Specific alleles and haplotype in the CMYA5 confer genetic risk for both schizophrenia and major depressive disorder in the Han Chinese population. PMID: 24988482
    3. meta-analysis confirming association of CMYA5 polymorphisms and schizophrenia in East Asian population. PMID: 24524722
    4. Association of cardiomyopathy-associated 5 (CMYA5) gene of Schizophrenia, is reported. PMID: 23528614
    5. In a Han Chinese sample of schizophrenic patients, SNPs within CMYA5 were associated with the disorder. PMID: 23778016
    6. CMYA5 is a new potential substrate of Kcna3 in human heart PMID: 23335746
    7. 2 SNPS in CYMA5, rs4704591 & rs10043986, are significantly associated with schizophrenia. Haplotype conditioned analyses indicated that the association signals observed at these two markers are independent. PMID: 20838396
    8. This study demonstrated that the association between CMYA5 and schizophrenia in Han Chinese. PMID: 21295948
    9. Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies. PMID: 20634290
    10. Functions directly downstream of MEF2A at the costamere in striated muscle potentially playing a role in myofibrillogenesis. PMID: 16407236
    11. perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin PMID: 17872945
    12. Polymorphism of myospryn is associated with left ventricular hypertrophy, and an association between a Z-disc protein and cardiac adaptation in response to pressure overload. PMID: 18344630
    13. Review discusses interactions that suggest myospryn is involved in two seemingly distinct processes, protein kinase A signalling and vesicular trafficking. PMID: 19140017

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  • 亞細(xì)胞定位：
    Nucleus. Sarcoplasmic reticulum. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, myofibril, sarcomere, M line.
  • 組織特異性：
    Expressed in skeletal muscle; at a strong level and in heart.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14305

    OMIM: 612193

    KEGG: hsa:202333

    STRING: 9606.ENSP00000394770

    UniGene: Hs.482625



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