在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Calcium and integrin-binding family member 2 (CIB2)

  • 中文名稱:
    Recombinant Human Calcium and integrin-binding family member 2(CIB2)
  • 貨號:
    CSB-YP005427HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Calcium and integrin-binding family member 2(CIB2)
  • 貨號:
    CSB-EP005427HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Calcium and integrin-binding family member 2(CIB2)
  • 貨號:
    CSB-EP005427HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Calcium and integrin-binding family member 2(CIB2)
  • 貨號:
    CSB-BP005427HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Calcium and integrin-binding family member 2(CIB2)
  • 貨號:
    CSB-MP005427HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CIB2
  • Uniprot No.:
  • 別名:
    Calcium and integrin binding protein 2; Calcium and integrin-binding family member 2; Cib2; CIB2_HUMAN; DNA dependent protein kinase interacting protein 2; Kinase interacting protein 2; Kinase-interacting protein 2; KIP 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-187
  • 氨基酸序列
    MGNKQTIFTE EQLDNYQDCT FFNKKDILKL HSRFYELAPN LVPMDYRKSP IVHVPMSLII QMPELRENPF KERIVAAFSE DGEGNLTFND FVDMFSVLCE SAPRELKANY AFKIYDFNTD NFICKEDLEL TLARLTKSEL DEEEVVLVCD KVIEEADLDG DGKLGFADFE DMIAKAPDFL STFHIRI
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process.
  • 基因功能參考文獻:
    1. this study identifies CIB1 and CIB2 as host helper factors for HIV-1 replication that are required for optimal receptor-mediated viral entry PMID: 27489023
    2. results suggest that GJB2 and CIB2 are common cause of hearing loss in different Pakistani ethnicities PMID: 29086887
    3. High CIB2 expression is associated with ovarian Cancer. PMID: 28729416
    4. Novel homozygous missense variant c.196C>T and compound heterozygous variants, c.[97C>T];[196C>T], were associated with nonsyndromic deafness. PMID: 26173970
    5. We identified a novel variant (rs7164338) on chromosome 15q25.1 in the CIB2 associated with lower pulse wave velocity. PMID: 26378684
    6. CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family PMID: 26426422
    7. Data indicate that that CIB2 localizes to stereocilia and interacts with the USH proteins myosin VIIa and whirlin, suggesting CIB2 is a Ca2+-buffering protein essential for calcium homeostasis in the mechanosensory stereocilia of inner ear hair cells. PMID: 24022220
    8. Consistent with molecular modeling predictions of calcium binding, CIB2 significantly decreased the ATP-induced calcium responses in heterologous cells, whereas mutations in deafness DFNB48 altered CIB2 effects on calcium responses PMID: 23023331
    9. CIB2, as binding partners for the integrin alphaIIb subunit, which suggests that they are potentially involved in regulating integrin alphaIIb subunit activation. PMID: 22779914

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Deafness, autosomal recessive, 48 (DFNB48); Usher syndrome 1J (USH1J)
  • 亞細胞定位:
    Cytoplasm. Cell projection, stereocilium. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Cell membrane, sarcolemma.
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 24579

    OMIM: 605564

    KEGG: hsa:10518

    STRING: 9606.ENSP00000258930

    UniGene: Hs.129867



主站蜘蛛池模板: 少妇人妻无码专区视频| 国产精品卡1卡2卡3网站| 亚洲中文有码字幕日本第一页| 欧美成人aaaa免费全部观看| 亚洲国产制服丝袜高清在线| 四虎精品免费永久免费视频| 婷婷色婷婷开心五月四房播播| 国产色视频一区二区三区| 欧洲多毛裸体xxxxx| 狼人亚洲国内精品自在线| 国产成人免费高清直播| 国产精品区av| 国产乱人对白| 国产蝌蚪视频一区二区三区| 国产成人av国语在线观看| 久久不见久久见免费视频观看| 欧美牲交40_50a欧美牲交aⅴ| 人人妻人人澡人人爽超污| 国产精品沙发系列| 秋霞午夜鲁丝片午夜精品| 国产亚洲精品综合一区| 99国内精品久久久久久久| 欧美一性一乱一交一视频| 色舞月亚洲综合一区二区| 无码中文av波多野结衣一区| 国产乱码一区二区三区| 高清偷自拍第1页| 猫咪av成人永久网站在线观看| 国产精品三级av及在线观看| 狠狠色狠狠色综合日日五| 亚洲成在人线视av| 久青草国产97香蕉在线影院| 产后漂亮奶水人妻无码| 四虎成人精品在永久免费| 国产乱妇乱子在线播放视频| 国产精品久久无码不卡黑寡妇| 99精品免视看| 国产精品美女久久久| 日本在线看片免费人成视频1000| 久久国产精品国产四虎90后| 国产青榴视频在线观看|