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  4. Recombinant Human CD109 antigen (CD109), partial

Recombinant Human CD109 antigen (CD109), partial

  • 中文名稱：
    Recombinant Human CD109 antigen(CD109) ,partial
  • 貨號：
    CSB-YP740988HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human CD109 antigen(CD109) ,partial
  • 貨號：
    CSB-EP740988HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human CD109 antigen(CD109) ,partial
  • 貨號：
    CSB-EP740988HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human CD109 antigen(CD109) ,partial
  • 貨號：
    CSB-BP740988HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human CD109 antigen(CD109) ,partial
  • 貨號：
    CSB-MP740988HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CD109
  • Uniprot No.：
  • 別名：
    150 KDa TGF beta 1 binding protein; 150 KDa TGF-beta-1-binding protein; 7D1; 8A3; Activated T cell marker CD109; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; CD 109; CD109; CD109 antigen; CD109_HUMAN; CPAMD7; DKFZp762L1111; E123; FLJ38569; FLJ41966; Gov system alloantigens on platelets; p180; Platelet specific Gov antigen; Platelet-specific Gov antigen; r150; RP11 525G3.1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Modulates negatively TGFB1 signaling in keratinocytes.
  • 基因功能參考文獻：
    1. GRP78 binds to and acts in concert with a glycosylphosphatidylinositol-anchored protein, CD109, in blocking TGF-beta signaling by promoting the routing of the TGF-beta receptor to the caveolae, thereby disrupting its binding to and activation of Smad2. PMID: 29654145
    2. CD109 knockdown upregulated IL-8 expression through activation of TGF-beta/Akt/NF-kappaB pathway in human umbilical vein endothelial cells PMID: 27121053
    3. High expression of CD109 in brain tumor stem cells is involved in glioma progression. PMID: 28888050
    4. The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta/Smad signaling through control of p-smad2. PMID: 27074923
    5. CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients. PMID: 28032275
    6. Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta RI was highly correlated with higher expression of Smad7 and Ki67, suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7-mediated degradation of TGF-beta RI. PMID: 26838754
    7. sCD109 can bind TGF-beta, inhibit TGF-beta binding to its receptors and decrease TGF-beta signalling and TGF-beta-induced cellular responses. PMID: 26621871
    8. These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome. PMID: 26707640
    9. CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas. PMID: 26249215
    10. CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma. PMID: 25388101
    11. expression increased in cutaneous squamous cell carcinoma PMID: 25271095
    12. The results suggest that circulating endothelial cells express CD109 and represent a rare population of circulating tumor endothelial cells, that play a potentially useful prognostic role in patients with glioblastoma. PMID: 25506915
    13. CD109 overexpression was significantly associated with surgical stage, distant metastasis, and poor prognosis in myxofibrosarcoma. PMID: 26031650
    14. Three glioblastoma cell lines, SK-MG-1, U251MG and MG178, were tested and CD109 overexpression attenuated TGF-beta1 signaling and enhanced EGF signaling in SK-MG-1, but not in U251MG or MG178. PMID: 25724945
    15. CD109 is highly expressed in TNBC and is a potential biomarker for the initiation, progression, and differentiation of breast cancer tumors. PMID: 25149155
    16. CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC PMID: 24667143
    17. High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in a novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma. PMID: 24376795
    18. Hematopoietic cell marker CD109 is expressed in hepatic progenitor cells. PMID: 24396288
    19. expression of CD109 (human platelet antigen 15) mRNA is different in various human cell types PMID: 23509816
    20. The upregulation of CD109 protein in SSc may represent an adaptation or consequence of aberrant TGF-beta signaling in systemic sclerosis PMID: 22694813
    21. CD109 is an important regulator of SMAD7/Smurf2-mediated degradation of TGFBR1. PMID: 21898545
    22. CD109 release from the cell surface in human keratinocytes regulates TGF-beta receptor expression, TGF-beta signalling and STAT3 activation. PMID: 21539622
    23. CD109 regulates TGF-beta receptor endocytosis and degradation to inhibit TGF-beta signaling. PMID: 21295082
    24. Report PRSS3/mesotrypsin upregulation in breast cancer cells and identify CD109 as the functional proteolytic target of mesotrypsin. PMID: 20035377
    25. These findings suggest that CD109 is involved in bladder tumorigenesis and is a potential target for cancer immunotherapy. PMID: 20946523
    26. Processing of CD109 into 180 kDa and 25 kDa proteins by furin, followed by complex formation with the type I TGF-beta receptor is required for the regulation of TGF-beta signaling in cancer cells and keratinocytes. PMID: 20101215
    27. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. cDNA sequence determination and protein structure analysis given. PMID: 11861284
    28. A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. PMID: 11861285
    29. Findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins. PMID: 15826242
    30. CD109 plays a unique role in the regulation of isoform-specific TGF-beta signaling in keratinocytes. PMID: 16754747
    31. Findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas. PMID: 17493171
    32. the novel gene HEPT3 may function through its noncoding RNA and its overexpression may play a role in hepatocarcinogenesis [HEPT3] PMID: 17611685
    33. CD109 expression may play a role in the development of lung squamous cell carcinoma. PMID: 17922683
    34. Up-regulation of CD109 expression is associated with carcinogensis of the squamous epithelium of the oral cavity. PMID: 19016750
    35. Found with a mutation in 7% of colon cancers studied. PMID: 16959974

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 組織特異性：
    Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and act
  • 數據庫鏈接：

    HGNC: 21685

    OMIM: 608859

    KEGG: hsa:135228

    STRING: 9606.ENSP00000287097

    UniGene: Hs.399891



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