在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human CCR4-NOT transcription complex subunit 6 (CNOT6)

Recombinant Human CCR4-NOT transcription complex subunit 6 (CNOT6)

  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 6(CNOT6)
  • 貨號(hào)：
    CSB-YP892149HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 6(CNOT6)
  • 貨號(hào)：
    CSB-EP892149HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 6(CNOT6)
  • 貨號(hào)：
    CSB-EP892149HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 6(CNOT6)
  • 貨號(hào)：
    CSB-BP892149HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 6(CNOT6)
  • 貨號(hào)：
    CSB-MP892149HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CNOT6
  • Uniprot No.：
  • 別名：
    A230103N10Rik; AA407540; AW456442; carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4 like; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex; subunit 6; Cnot6; CNOT6_HUMAN; Cytoplasmic deadenylase; EC 3.1.-.-; fa03c11; fc17f01; KIAA1194; MGC98472; OTTHUMP00000161544; wu:fa03c11; wu:fc17f01; zgc:65822
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-557
  • 氨基酸序列
    MPKEKYEPPD PRRMYTIMSS EEAANGKKSH WAELEISGKV RSLSASLWSL THLTALHLSD NSLSRIPSDI AKLHNLVYLD LSSNKIRSLP AELGNMVSLR ELHLNNNLLR VLPFELGKLF QLQTLGLKGN PLTQDILNLY QEPDGTRRLL NYLLDNLSGT AKRITTEQPP PRSWIMLQEP DRTRPTALFS VMCYNVLCDK YATRQLYGYC PSWALNWDYR KKAIIQEILS CNADIVSLQE VETEQYYSFF LVELKERGYN GFFSPKSRAR TMSEQERKHV DGCAIFFKTE KFTLVQKHTV EFNQLAMANS EGSEAMLNRV MTKDNIGVAV LLELRKESIE MPSGKPHLGT EKQLILVANA HMHWDPEYSD VKLVQTMMFL SEVKNIIDKA SRNLKSSVLG EFGTIPLVLC ADLNSLPDSG VVEYLSTGGV ETNHKDFKEL RYNESLTNFS CHGKNGTTNG RITHGFKLQS AYESGLMPYT NYTFDFKGII DYIFYSKPQL NTLGILGPLD HHWLVENNIS GCPHPLIPSD HFSLFAQLEL LLPFLPQVNG IHLPGRR
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
  • 基因功能參考文獻(xiàn)：
    1. The CNOT6 rs2453176 Single Nucleotide Polymorphism may be a new functional susceptible locus for lung cancer risk. PMID: 27805284
    2. miR-29c-3p promotes the senescence of Mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways. PMID: 26792405
    3. These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module. PMID: 25944446
    4. Results identified CNOT6/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a p53-dependent pathway. PMID: 21233283
    5. CCR4 and BTG2 interact and have a role in cell-cycle regulation PMID: 12771185
    6. CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and RCD1 and CCR4 might mediate their function through their interaction with NIF-1 PMID: 18180299
    7. hCCR4/cNOT6 targets DNA-damage response proteins PMID: 18818012
    8. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT6 binds CNOT8 in yeast two-hybrid assays. PMID: 19558367

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CCR4/nocturin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14099

    OMIM: 608951

    KEGG: hsa:57472

    STRING: 9606.ENSP00000261951

    UniGene: Hs.608380



主站蜘蛛池模板： 国产99久9在线视频 | 传媒| 强睡邻居人妻中文字幕| 欧美国产日韩a在线视频| 国内精品久久久久影院老司机 | a毛片免费全部播放| 国内自拍五区| 成年丰满熟妇午夜免费视频| 亚欧免费无码aⅴ在线观看蜜桃| 久久久一本精品99久久精品66直播 | 国产免费牲交视频| 国偷自产av一区二区三区| 亚洲人成在线观看网站不卡| 国产97色在线 | 日| 国产精品久久久一区二区三区| 色欲色香天天天综合无码www| 国产色视频自在线观看| 精品四虎国产在免费观看| 精品国产一区二区三区久久久狼| 欧美激情性做爰免费视频| 久久久精品久久日韩一区综合| 夜夜欢性恔真人免费视频| 久久成人国产精品| 久久精品中文闷骚内射| 欧美饥渴熟妇高潮喷水| 日韩~欧美一中文字幕| www一区二区www免费| 综合图片亚洲综合网站| 又大又粗又爽免费视频a片| 国产色a在线观看| 粗了大了 整进去好爽视频| 九九热线有精品视频| 在线观看无码av网站永久免费| 国产精品久久久久9999| 国产互换人妻hd| 最近高清中文在线字幕在线观看1| 丁香婷婷综合激情五月色| av色欲无码人妻中文字幕| 精品毛片乱码1区2区3区| 久久综合久中文字幕青草| 国产精品亚洲а∨天堂2021| 天堂在线资源中文在线8|