在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human CCR4-NOT transcription complex subunit 1 (CNOT1), partial

Recombinant Human CCR4-NOT transcription complex subunit 1 (CNOT1), partial

  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 1(CNOT1) ,partial
  • 貨號：
    CSB-YP005663HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 1(CNOT1) ,partial
  • 貨號：
    CSB-EP005663HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 1(CNOT1) ,partial
  • 貨號：
    CSB-BP005663HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human CCR4-NOT transcription complex subunit 1(CNOT1) ,partial
  • 貨號：
    CSB-MP005663HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CNOT1
  • Uniprot No.：
  • 別名：
    CNOT1; CDC39; KIAA1007; NOT1; AD-005CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog; NOT1H; hNOT1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.
  • 基因功能參考文獻(xiàn)：
    1. These results together with the authors' previous study, have identified that CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTPmediated ICAM1 and IL8 mRNA decay. PMID: 29956766
    2. YTHDF2 recruits the CCR4-NOT complex through a direct interaction between the YTHDF2 N-terminal region and the SH domain of the CNOT1 subunit, and that this recruitment is essential for the deadenylation of m6A-containing RNAs by CAF1 and CCR4. PMID: 27558897
    3. the CNOT1-LMNA-Hedgehog signaling pathway axis exerts an oncogenic role in osteosarcoma progression, which could be a potential target for gene therapy. PMID: 28188704
    4. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
    5. miRNAs, AGOs, GW182, the CCR4-NOT complex, and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells PMID: 27009120
    6. Single nucleotide polymorphism in CNOT1 gene is associated with osteosarcoma susceptibility. PMID: 25663449
    7. CNOT1 facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway. PMID: 25035296
    8. SNP rs7188697 A/G significantly associated with response to dendritic cells therapeutic HIV vaccine PMID: 24433985
    9. Crystal structures of the DDX6, CNOT1 and CNOT9 complexes. PMID: 24768538
    10. Crystal structure of the DDX6, CNOT9 and CNOT1 complex. PMID: 24768540
    11. The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure. PMID: 24121232
    12. Authors identify an evolutionarily conserved C-terminal motif in human TTP that directly binds a central domain of CNOT1, a core subunit of the CCR4-NOT complex. PMID: 23644599
    13. The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates. PMID: 22977175
    14. Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs. PMID: 22367759
    15. Depletion of CNOT1 induces cell death in a caspase-dependent manner. PMID: 21976065
    16. purification and characterization of 1.0 MDa yeast CCR4-NOT complex identifies two novel components, CAF40 and CAF130: yeast CAF40 binds human NOT1 PMID: 11733989
    17. CNOT1 interacts in a ligand-dependent manner with RXR and represses transcription mediated by several RXR heterodimers. PMID: 16778766
    18. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT1 binds CNOT4 in yeast two-hybrid assays. PMID: 19558367

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, P-body. Nucleus.
  • 蛋白家族：
    CNOT1 family
  • 組織特異性：
    Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7877

    OMIM: 604917

    KEGG: hsa:23019

    STRING: 9606.ENSP00000320949

    UniGene: Hs.460923



主站蜘蛛池模板： 人妻av无码中文专区久久| 日本中文字幕一区二区有码在线| 亚洲精品午夜无码电影网| 亚洲综合色视频在线观看| 久久综合亚洲色hezyo社区| 欧美成人秋霞久久aa片| 国产一区二区三区四区精华| 人人狠狠综合久久亚洲爱咲 | 国产无遮挡又爽又黄的视频| 蜜臀av性久久久久蜜臀aⅴ麻豆| 夜鲁鲁鲁夜夜综合视频欧美| 伊人久久大香线蕉综合直播| 麻豆国产原创视频在线播放 | 免费人成在线观看网站品爱网| 男女高潮激烈免费观看| 欧美黑人添添高潮a片www| 加勒比无码人妻东京热| 国内免费视频成人精品| 国产在线视频www色| 四虎国产成人永久精品免费| а√天堂www在线а√天堂视频| 久久亚洲色www成人不卡| 亚洲丰满熟女一区二区v| 久久99精品国产麻豆婷婷| 蜜桃日本免费观看mv| 色av专区无码影音先锋| 日韩国产成人无码av毛片| 亚洲中文字幕精品久久久久久动漫| 国产片a国产片免费看视频| 国产精品永久久久久久久久久| 成 人 色 网 站免费观看| 日日做夜狠狠爱欧美黑人| 丰满少妇夜夜爽爽高潮水| 欧美内射深喉中文字幕| 亚洲国产精品久久网午夜| 日韩人妻潮喷中文在线视频| 欧美天天拍在线视频| 一日本道a高清免费播放| 成年女人午夜毛片免费视频| 少妇人妻挤奶水中文视频毛片| 影音先锋男人av鲁色资源网|