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  4. Recombinant Human CASP8-associated protein 2 (CASP8AP2), partial

Recombinant Human CASP8-associated protein 2 (CASP8AP2), partial

  • 中文名稱：
    Recombinant Human CASP8-associated protein 2(CASP8AP2) ,partial
  • 貨號：
    CSB-YP890737HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human CASP8-associated protein 2(CASP8AP2) ,partial
  • 貨號：
    CSB-EP890737HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human CASP8-associated protein 2(CASP8AP2) ,partial
  • 貨號：
    CSB-EP890737HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human CASP8-associated protein 2(CASP8AP2) ,partial
  • 貨號：
    CSB-BP890737HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human CASP8-associated protein 2(CASP8AP2) ,partial
  • 貨號：
    CSB-MP890737HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CASP8AP2
  • Uniprot No.：
  • 別名：
    AA387232; C8AP2_HUMAN; CASP 8 associated protein 2; CASP8 associated protein 2; CASP8-associated protein 2; CASP8AP2; Caspase 8 associated protein 2; CED 4; CED4; D4Ertd659e; FLASH homolog; FLASH homolog RIP 25; FLASH homolog RIP25; FLICE associated huge; FLICE associated huge protein; FLICE-associated huge protein; FLJ11208; KIAA1315; mKIAA1315; OTTMUSP00000005125; RIP 25; RIP25; RP23-69G24.1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
  • 基因功能參考文獻：
    1. FLASH plays two roles in 3' end processing of histone pre-mRNAs: It interacts with Lsm11 to form a docking platform for the polyadenylation factors, and it cooperates with SLBP to recruit U7 snRNP to histone pre-mRNA. PMID: 28289156
    2. FLASH is required for embryogenesis, but not for cell proliferation or differentiation in embryonic stem cells. PMID: 25238250
    3. Our results indicate that the APAF1, BAX, and FLASH genes not only harbor frameshift mutations but also demonstrate mutational ITH, which together might play a role in the tumorigenesis of CRC with MSI-H by affecting the apoptosis of cancer cells. PMID: 25599959
    4. High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. PMID: 24941917
    5. the predictive values regarding low expressions of H2AFZ and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse. PMID: 24397596
    6. ARS2 and CASP8AP2 expressions can precisely predict high-risk of relapse and ALL prognosis. PMID: 25530566
    7. The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies. PMID: 25339177
    8. Data suggest that SUMO targets FLASH for proteasome-dependent degradation, which is associated with recruitment of FLASH to PML bodies. PMID: 23673342
    9. Hypermethylation of two CpG sites upstream of CASP8AP2 promoter influences gene expression and treatment outcome in childhood acute lymphoblastic leukemia. PMID: 23953914
    10. FLASH/Lsm11 complex bind a unique combination of polyadenylation factors PMID: 23071092
    11. These data demonstrate that methylation within the Casp8AP2 promoter correlates with the development of drug resistance and might serve as a biomarker and treatment target for drug resistance in cancer cells. PMID: 22595458
    12. FLASH knockdown in HT1080 mutant cells defective in p53 did not significantly accelerate Fas mediated apoptosis indicating that the effect was dependent on functional p53. PMID: 22427918
    13. This study further defines the role CASP8AP2/FLASH plays in the regulating expression of the replication-dependent histones and shows that its LOF results in broad and reproducible effects on the transcriptome of colorectal cancer cells PMID: 22216762
    14. Data show that show that the transcription factor p73 binds to Flice-Associated Huge Protein (FLASH) and is part of the complex that regulates histone gene transcription. PMID: 21725362
    15. CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia. PMID: 21696825
    16. PIAS1 is a common partner for two cancer-related nuclear factors, c-Myb and FLASH. PMID: 21338522
    17. Critical residues in human FLASH and Lsm11 that are involved in the interaction between these two proteins, are identified. PMID: 21245389
    18. investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan PMID: 20109966
    19. endogenous caspase-8 mediates tumor necrosis factor-alpha-induced activation of NF-kappaB via FLASH PMID: 15592525
    20. FLASH differentially suppresses steroid hormone receptor-induced transcriptional activity by interfering with their association with steroid hormone receptor coactivator 2 (SRC2)/N-CoA2 and SRC3/N-CoA3 PMID: 15698540
    21. High levels of CASP8AP2 expression were associated with a greater propensity of leukemic lymphoblasts to undergo apoptosis PMID: 16627760
    22. These results identify FLASH as an important component of the machinery required for histone precursor mRNA expression and cell-cycle progression. PMID: 17003125
    23. FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. PMID: 17003126
    24. CD95 signals are mediated by nucleo-cytoplasmic translocation of FLASH. PMID: 17245429
    25. increased expression of FLASH in malignant gastric epithelial cells compared to the normal cells suggests that FLASH expression may play a role in gastric tumorigenesis; data suggest that somatic mutation of FLASH is a rare event in gastric carcinomas PMID: 17696945
    26. Frameshift mutation in the polyadenine tracts in both FLASH and PTPN13 genes is rare in colorectal carcinomas. Both FLASH and PTPN13 mutations in the polyadenine tracts may not have a crucial role in the pathogenesis of colorectal carcinomas. PMID: 18038312
    27. c-Myb cooperates with FLASH in foci associated with active RNA polymerase II, leading to enhancement of Myb-dependent gene activation. PMID: 18408764
    28. Only the number of FLASH/NPAT histone gene locus bodies correlates with ploidy and only these organelles appear to be regulated during the cell cycle. PMID: 18677100
    29. a deletion at 6q15-16.1 in 9 of 73 (12%) of the childhood T-ALL patients predicts poor early treatment response. This deletion includes the CASP8AP2 gene, whose expression is shown to be down-regulated. PMID: 19406988
    30. Results suggest that FLASH functions in S phase progression through interaction with ARS2. PMID: 19546234
    31. these results point to a complex involvement of sumoylation in modulating the function of FLASH. PMID: 19615980
    32. Human FLASH interacts with Lsm11 in vitro and stimulates 3' end processing of histone pre-mRNA in mammalian nuclear extracts. PMID: 19854135

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
  • 數據庫鏈接：

    HGNC: 1510

    OMIM: 606880

    KEGG: hsa:9994

    UniGene: Hs.558218



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