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  4. Recombinant Human C4b-binding protein beta chain (C4BPB)

Recombinant Human C4b-binding protein beta chain (C4BPB)

  • 中文名稱：
    Recombinant Human C4b-binding protein beta chain(C4BPB)
  • 貨號：
    CSB-YP003954HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human C4b-binding protein beta chain(C4BPB)
  • 貨號：
    CSB-EP003954HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human C4b-binding protein beta chain(C4BPB)
  • 貨號：
    CSB-EP003954HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human C4b-binding protein beta chain(C4BPB)
  • 貨號：
    CSB-BP003954HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human C4b-binding protein beta chain(C4BPB)
  • 貨號：
    CSB-MP003954HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    C4b binding protein beta chain; C4b-binding protein beta chain; C4BP; C4BPB; C4BPB_HUMAN; Complement component 4 binding protein beta; Complement component 4 binding protein beta chain; Complement component 4-binding protein beta; OTTHUMP00000034288; OTTHUMP00000034289; OTTHUMP00000034375; OTTHUMP0000003474; Proline rich protein; PRP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    18-252
  • 氨基酸序列
    SDA EHCPELPPVD NSIFVAKEVE GQILGTYVCI KGYHLVGKKT LFCNASKEWD NTTTECRLGH CPDPVLVNGE FSSSGPVNVS DKITFMCNDH YILKGSNRSQ CLEDHTWAPP FPICKSRDCD PPGNPVHGYF EGNNFTLGST ISYYCEDRYY LVGVQEQQCV DGEWSSALPV CKLIQEAPKP ECEKALLAFQ ESKNLCEAME NFMQQLKESG MTMEELKYSL ELKKAELKAK LL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
  • 基因功能參考文獻：
    1. SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB PMID: 28278182
    2. Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells. PMID: 24064215
    3. crystallographic data on the structure of CD11c/CD18 and prediction of the secondary structure of the C4BP oligomerization domain, we show that epitopes bound by KIM185 in these proteins are unlikely to share any major structural similarity. PMID: 21856004
    4. C4BP alpha7beta0 subunit [C4BP alpha7beta0 isoform lacking the beta-chain] induces a semimature, tolerogenic state on human monocyte-derived dendritic cells activated by a proinflammatory stimulus. PMID: 23390292
    5. Since FI requires cofactors for its activity we also investigated the binding of purified cofactors C4BP and FH and found acquisition of both proteins, which retained their activity in FI mediated degradation of C3b and C4b. PMID: 22514678
    6. Results demonstrate that successful secretion of complement regulatory protein C4b-binding protein beta-chains depends on intracellular complex formation with vitamin K-dependent protein S, but not on the alpha-chains. PMID: 20693287
    7. Localized via protein S to the surface of apoptotic cells, C4BP is able to interact with complement protein C4b, thus retaining its physiological role in regulation of complement on the apoptotic cell surface. PMID: 12193728
    8. C4BP is composed of seven alpha-chains and a unique beta-chain, each chain comprising repeating complement control protein (CCP) modules, the results suggest that the role of CCP2 in protein S binding is to orient and stabilize CCP1 PMID: 12492479
    9. C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation. PMID: 15967823
    10. analysis of structural basis for C4b-binding protein interaction with streptococcal M protein PMID: 16330538
    11. review of multiple functional roles of the complex of protein S and cd4-binding protein beta chain, such as binding to apoptotoic cells, phagocytosis PMID: 17597997
    12. C4BP levels are increased in patients suffering from primary Sjogren's syndrome PMID: 19284503

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  • 亞細胞定位：
    Secreted.
  • 數據庫鏈接：

    HGNC: 1328

    OMIM: 120831

    KEGG: hsa:725

    STRING: 9606.ENSP00000243611

    UniGene: Hs.99886



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