在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human C1GALT1-specific chaperone 1 (C1GALT1C1), partial

Recombinant Human C1GALT1-specific chaperone 1 (C1GALT1C1), partial

  • 中文名稱：
    Recombinant Human C1GALT1-specific chaperone 1(C1GALT1C1),partial
  • 貨號(hào)：
    CSB-YP003490HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human C1GALT1-specific chaperone 1(C1GALT1C1),partial
  • 貨號(hào)：
    CSB-EP003490HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human C1GALT1-specific chaperone 1(C1GALT1C1),partial
  • 貨號(hào)：
    CSB-EP003490HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human C1GALT1-specific chaperone 1(C1GALT1C1),partial
  • 貨號(hào)：
    CSB-BP003490HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human C1GALT1-specific chaperone 1(C1GALT1C1),partial
  • 貨號(hào)：
    CSB-MP003490HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    C1GALT1C1
  • Uniprot No.：
  • 別名：
    HSPC067; 3-galactosyltransferase 2; Beta 1,3 galactosyltransferase 2 ; Beta1,3 galactosyltransferase 2 ; C1Gal T2 ; C1Gal-T2; C1GALT1 specific chaperone 1 ; C1GALT1-specific chaperone 1; C1galt1c1; C1GalT2; C1GLC_HUMAN; C38H2 L1; C38H2 like protein 1; C38H2-L1; C38H2-like protein 1; C38H2L1; Core 1 beta1; Core 1 beta3 galactosyltransferase specific molecular chaperone; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone; Core 1 UDP galactose:N acetylgalactosamine alpha R beta 1,3 galactosyltransferase 2 ; COSMC ; MGC19947; MST143
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).
  • 基因功能參考文獻(xiàn)：
    1. In addition, we found that Tn-expressing colorectal cancers (CRC) cell lines had either loss-of-function mutations in Cosmc or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase activity PMID: 30115016
    2. elevated Tn levels in cancer and inflammation may be commonly regulated by the cytokine (TNFa and IL6)-Cosmc signaling axis PMID: 27542280
    3. The data suggest that hypermethylation of the Cosmc promoter may induce the expression of Tn antigen in activated T cells. PMID: 28708980
    4. results provide new structure-function insight to Cosmc, indicate that Cosmc behaves as a modular protein and suggests points of modulation or regulation of in vivo chaperone function PMID: 28665962
    5. Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1GALT1) and C1GALT1-specific chaperone 1 protein (C1GALT1C1) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells. PMID: 28187132
    6. The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1. TGFbeta1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGFbeta1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc. PMID: 28035353
    7. mutations c.393T>A and c.72A>G in the exon region of Cosmc gene in children with Henoch-Schonlein purpura (HSP) are not associated with the onset of Henoch-Schonlein purpura PMID: 27412546
    8. Data suggest that patients with IgA nephropathy exhibit higher microRNA-374b in B cells compared to controls; microRNA-374b appears to target PTEN (phosphatase and tensin homolog) and Cosmc (C1GALT1 specific chaperone 1) proteins. PMID: 26545495
    9. These results indicate that Tn antigens expression and T-synthase inactivity in HT-29-Tn+ cells can be related to the absence of the Cosmc gene coding sequence in Cosmc active alleles PMID: 26045765
    10. the impact of COSMC mediated Tn antigen expression in two human pancreatic ductal adenocarcinoma cell lines on cellular oncogenic properties, were investigated. PMID: 26021314
    11. hypermethylation of Cosmc promoter region could be a key mechanism for the reduction of Cosmc mRNA expression in IgAN lymphocytes with associated increase in aberrantly glycosylated IgA1 PMID: 25647400
    12. Cosmc and T-synthase are transcriptionally regulated at a basal level by the specificity protein/Kruppel-like transcription factor family of members. PMID: 26063800
    13. CBRT is a unique recognition motif for Cosmc to promote its regulation and formation of active T-synthase and represents the first sequence-specific chaperone recognition system in the ER/Golgi required for normal protein O-glycosylation PMID: 24616093
    14. Data indicate that cytotoxin associated gene A protein (CagA) promoted the underglycosylation of IgA1, which at least partly attributed to the downregulation of beta1,3-galactosyltransferase (C1GALT1) and its chaperone Cosmc. PMID: 24462875
    15. overexpression of Cosmc is associated with colorectal cancer. PMID: 23390052
    16. COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma PMID: 23424651
    17. The mRNA expression level of Cosmc gene in IgA nephropathy patients was significantly lower than that of controls. De-methylation modification up regulated the Cosmc gene expression significantly. PMID: 22332537
    18. Results show that soluble Cosmc directly interacts in a specific manner with denatured, but not native, T-synthase to form a noncovalent and reversible complex that results in the acquisition of T-synthase catalytic activity. PMID: 22416136
    19. Results indicate that Cosmc mediates the co-translational activation of C1GalT and that it may prevent the unfavorable aggregation of C1GalT. PMID: 21496458
    20. The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum PMID: 21262965
    21. Study results suggest that C1GALT1C1 may play a key role in the regulation of IgA1 O-glycosylation. PMID: 20144270
    22. Cosmc represents the first endoplasmic reticulum chaperone identified to be required for folding of a glycosyltransferase PMID: 19923218
    23. molecular cloning and characterization; C1Gal-T2 is the second candidate for core 1 synthase that plays an important role in synthesizing O-glycans in digestive organs PMID: 12361956
    24. Tn syndrome is associated with a somatic mutation in Cosmc, a gene on the X chromosome that encodes a molecular 'chaperone' that is required for the proper folding and hence full activity of T-synthase PMID: 16251947
    25. These results suggest that the intracellular dynamics of C1GalT is controlled by its specific molecular chaperon, Cosmc, in association with core 1 synthase activity. PMID: 18061573
    26. The tumor-specific antigen caused by mutant COSMC seems to be rare and is not potentially a therapeutic target candidate in breast and colon cancers. PMID: 18321367
    27. Colon cancer and melanoma-derived cells lines expressed Tn and STn antigen due to loss-of-function mutations in Cosmc. Cervical cancer specimens that showed expression of the Tn/STn antigens were also found to have mutations in Cosmc. PMID: 18339842
    28. a novel inactivating mutations (Glu152Lys, Ser193Pro and Met1Ile) in the coding sequence of C1GALT1C1 PMID: 18537974
    29. Cosmc is an endoplasmic reticulum (ER)-localized adenosine triphosphate binding chaperone that binds directly to human T-synthase. PMID: 18695044
    30. Although decreased C1GALT1 activity has been implicated in IgAN pathogenesis and cosmc chaperone mutations can cause autoimmune disease, our data provide no evidence for a role of cosmc gene mutations in European patients with sporadic or familial IgAN. PMID: 18840896
    31. The c.-347-190G>A polymorphism and the somatic mutation of encoding region of C1GALT1C1 gene were not significantly related to the genetic susceptibility to IgAN in Northern Chinese population PMID: 19778426

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Tn polyagglutination syndrome (TNPS)
  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 31 family, Beta3-Gal-T subfamily
  • 組織特異性：
    Ubiquitously expressed. Abundantly expressed in salivary gland, stomach, small intestine, kidney, and testis and at intermediate levels in whole brain, cerebellum, spinal cord, thymus, spleen, trachea, lung, pancreas, ovary, and uterus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24338

    OMIM: 300611

    KEGG: hsa:29071

    STRING: 9606.ENSP00000304364

    UniGene: Hs.643920



主站蜘蛛池模板： 狠狠综合久久久久尤物| 国产精品无码一区二区三区电影 | 无码h肉动漫在线观看| 中国女人内谢69xxxx视频| 国产亚洲精久久久久久无码77777| 欧美专区日韩视频人妻| 欧美精品中文字幕在线视| 午夜精品乱人伦小说区| 国产乱子影视频上线免费观看| 鲁鲁鲁爽爽爽在线视频观看| 成人综合婷婷国产精品久久| 国产精品久久综合免费| 亚洲欧美综合精品成人导航 | 亚洲人成网站18禁止人| 成人免费午夜无码视频在线播放| 丝袜高潮流白浆潮喷在线播放| 久久久久久久99精品免费观看| 非洲人与性动交ccoo| 欧美激情一区二区三区| 欧美亚洲国产手机在线有码| 国产av亚洲精品久久久久久小说 | 无码av中文字幕免费放| 亚洲2020天天堂在线观看| 97久久超碰国产精品旧版麻豆| 狠狠躁天天躁中文字幕| 日本japanese丰满白浆| 国产精品视频一区二区三区无码| 国语高潮无遮挡无码免费看| 朝鲜女子内射杂交bbw| 欧美成人片一区二区三区| 人人妻人人爽人人做夜欢视频| 亚洲免费人成视频观看| 欧美高清大屁股xxxxx| www国产无套内射com| 日韩精品无码一区二区| 狠狠色丁香五月综合缴情婷婷五月 | 中文字幕一精品亚洲无线一区 | 国产一区二区三区成人欧美日韩在线观看 | 国产香蕉尹人在线观看视频| 97人妻精品一区二区三区| 三级久久试看3分钟|