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  4. Recombinant Human C-type lectin domain family 1 member B (CLEC1B), partial

Recombinant Human C-type lectin domain family 1 member B (CLEC1B), partial

  • 中文名稱：
    Recombinant Human C-type lectin domain family 1 member B(CLEC1B),partial
  • 貨號：
    CSB-YP885789HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 1 member B(CLEC1B),partial
  • 貨號：
    CSB-EP885789HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 1 member B(CLEC1B),partial
  • 貨號：
    CSB-EP885789HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 1 member B(CLEC1B),partial
  • 貨號：
    CSB-BP885789HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 1 member B(CLEC1B),partial
  • 貨號：
    CSB-MP885789HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLEC1B
  • Uniprot No.：
  • 別名：
    1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1 member B; C-type lectin domain family 1; member B; C-type lectin-like receptor 2; C-type lectin-like receptor-2; CLC1B_HUMAN; CLEC 2; CLEC 2B; CLEC-2; CLEC1B; CLEC2; CLEC2B; PRO1384; QDED721
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2.; (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2.; (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
  • 基因功能參考文獻：
    1. CLEC-2 may have a role in unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma PMID: 27564117
    2. CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk. PMID: 28296036
    3. Data (including data from studies using cells from knockout mice) suggest that CLEC2/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 = C-type lectin CLEC2; CLEC2R = CLEC2 receptor; GNAQ = guanine nucleotide-binding protein G[q] subunit alpha) PMID: 28705934
    4. CLEC2 prevents expression of PI3K subunits, in a SYK-dependent manner, to suppress the invasive activities of gastric cancer cells. PMID: 26855187
    5. CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion. PMID: 25858425
    6. Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of CD36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2). PMID: 25849538
    7. PI3K and Tec family kinases play a crucial role in the regulation of platelet activation and Syk phosphorylation downstream of the CLEC-2 receptor PMID: 25767114
    8. fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway PMID: 23341451
    9. Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade PMID: 23264619
    10. A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation. PMID: 23053573
    11. The glycosylation sites (N120 and N134) are necessary for the surface expression of CLEC-2. PMID: 22740230
    12. Shedding of CLEC-2 from the cell surface may reflect increased expression of this membrane protein and serve as a marker of disease activity. PMID: 22736279
    13. CLEC-2 is the first member of the C-type lectin family of receptors identified to stimulate platelet aggregation through a tyrosine kinase-dependent pathway. (Review) PMID: 21714702
    14. Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac1. PMID: 20154214
    15. CLEC-2 activates Syk through dimerization. PMID: 20154219
    16. X-ray diffraction analysis of human CLEC-2 PMID: 16511244
    17. Framework for understanding the effects of rhodocytin venom binding on CLEC-2 and for understanding the nature of endogenous ligands which will provide a basis for rational design of drugs to block ligand binding. PMID: 17132623
    18. Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC2, is reported. PMID: 18583525
    19. It is the novel platelet activation receptor. (review) PMID: 19483399
    20. CLEC-2 exists as a non-disulfide-linked homodimer which could allow each Syk molecule to interact with two YXXL motifs, one from each CLEC-2 monomer. PMID: 19824697

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  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
  • 數據庫鏈接：

    HGNC: 24356

    OMIM: 606783

    KEGG: hsa:51266

    STRING: 9606.ENSP00000298527

    UniGene: Hs.409794



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