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  4. Recombinant Human Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A), partial

Recombinant Human Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A), partial

  • 中文名稱：
    Recombinant Human Bromodomain adjacent to zinc finger domain protein 1A(BAZ1A) ,partial
  • 貨號：
    CSB-YP885707HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain adjacent to zinc finger domain protein 1A(BAZ1A) ,partial
  • 貨號：
    CSB-EP885707HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain adjacent to zinc finger domain protein 1A(BAZ1A) ,partial
  • 貨號：
    CSB-EP885707HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain adjacent to zinc finger domain protein 1A(BAZ1A) ,partial
  • 貨號：
    CSB-BP885707HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain adjacent to zinc finger domain protein 1A(BAZ1A) ,partial
  • 貨號：
    CSB-MP885707HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    BAZ1A
  • Uniprot No.：
  • 別名：
    Acf1; ACF1; drosophila; homolog of; ATP dependent chromatin remodelling protein; ATP utilizing chromatin assembly and remodeling factor 1; ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; B930060C03; Baz1a; BAZ1A_HUMAN; BC065123; Bromodomain adjacent to zinc finger domain 1A; Bromodomain adjacent to zinc finger domain protein 1A; cbp146; CHRAC subunit ACF1; DKFZp586E0518; FLJ14383; Gtl5; hACF1; hWALp1; WALp1; WCRF180; Williams syndrome transcription factor related chromatin remodeling factor 180; Williams syndrome transcription factor-related chromatin-remodeling factor 180
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

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靶點詳情

  • 功能：
    Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression.
  • 基因功能參考文獻：
    1. Results from the study on gene variability in early stage embryos identifies BAZ1A as a putative variability marker of the 8-cell embryo stage. PMID: 26288249
    2. Results from the study suggest that acute cocaine exposure increased Baz1a expression in nucleus accumbens while repeated cocaine exposure produced the opposite effect. Findings implicate BAZ1A in molecular and behavioral plasticity to cocaine and offer new insight into the pathophysiology of cocaine addiction. PMID: 28412501
    3. promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin PMID: 29021563
    4. Study reports de novo mutation in BAZ1A, in a patient with a syndromic form of intellectual disability (ID). This mutation affects the expression of genes involved in several biological pathways such as vitamin D regulation, Wnt signaling, and postsynaptic signaling. Data point to an important role for BAZ1A in neurodevelopment, and highlight a possible link for BAZ1A to ID. PMID: 27328812
    5. CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities. PMID: 25533843
    6. ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes. PMID: 21738833
    7. hACF1-containing factors are more generally involved in the DNA damage response. PMID: 21745822
    8. The ACF1 and its complexes play important roles in DNA double-strand breaks (DSBs) repair. PMID: 21172662
    9. The data support a model in which the human ACF anf yeast RSC remodeling enzymes move nucleosomes to new locations by a general sequence-independent mechanism. PMID: 19450608
    10. ACF1 alters the remodeling strategy of SNF2h PMID: 16877760
    11. Has a critical role in the transcriptional repression of specific nuclear hormone receptor-regulated genes. PMID: 17519354

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  • 亞細胞定位：
    Nucleus. Note=May target the CHRAC complex to heterochromatin.
  • 蛋白家族：
    WAL family
  • 組織特異性：
    Highly expressed in testis and at low or undetectable levels in other tissues analyzed.
  • 數據庫鏈接：

    HGNC: 960

    OMIM: 605680

    KEGG: hsa:11177

    STRING: 9606.ENSP00000353458

    UniGene: Hs.509140



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