在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Beta-ureidopropionase (UPB1)

  • 中文名稱:
    人UPB1重組蛋白
  • 貨號:
    CSB-YP890662HU
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人UPB1重組蛋白
  • 貨號:
    CSB-EP890662HU
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人UPB1重組蛋白
  • 貨號:
    CSB-EP890662HU-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人UPB1重組蛋白
  • 貨號:
    CSB-BP890662HU
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人UPB1重組蛋白
  • 貨號:
    CSB-MP890662HU
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    UPB1
  • Uniprot No.:
  • 別名:
    UPB1; BUP1; Beta-ureidopropionase; EC 3.5.1.6; BUP-1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-384
  • 氨基酸序列
    MAGAEWKSLE ECLEKHLPLP DLQEVKRVLY GKELRKLDLP REAFEAASRE DFELQGYAFE AAEEQLRRPR IVHVGLVQNR IPLPANAPVA EQVSALHRRI KAIVEVAAMC GVNIICFQEA WTMPFAFCTR EKLPWTEFAE SAEDGPTTRF CQKLAKNHDM VVVSPILERD SEHGDVLWNT AVVISNSGAV LGKTRKNHIP RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL NWLMYSINGA EIIFNPSATI GALSESLWPI EARNAAIANH CFTCAINRVG TEHFPNEFTS GDGKKAHQDF GYFYGSSYVA APDSSRTPGL SRSRDGLLVA KLDLNLCQQV NDVWNFKMTG RYEMYARELA EAVKSNYSPT IVKE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide.
  • 基因功能參考文獻:
    1. The c.977G>A (p.R326Q) is the most common mutation of the UPB1 gene in Chinese. The predicted incidence indicates that beta-ureidopropionase deficiency is significantly underdiagnosed in the Chinese population. PMID: 25236466
    2. High prevalence of p.R326Q in the normal Japanese population indicates that betaUP deficiency is not as rare as generally considered PMID: 24526388
    3. This study reports the clinical, biochemical, and molecular analysis of a newly identified patient with beta-ureidopropionase deficiency and the effect of the first synonymous mutation in UBP1 affecting pre-mRNA splicing, using the minigene approach. PMID: 24328561
    4. analysis of UPB1 variants on 5-FU-related toxicity in the population of all analyzed patients revealed an association between the c.-80C>G (rs2070474) variant and gastrointestinal toxicity PMID: 23238479
    5. biochemical and molecular findings of 11 newly identified ss-ureidopropionase deficient patients as well as the analysis of the mutations in a three-dimensional framework were reported. PMID: 22525402
    6. An altered homeostasis of beta-aminoisobutyric acid and/or increased oxidative stress might contribute to some of the clinical abnormalities encountered in patients with a beta-ureidopropionase deficiency. PMID: 15385443
    7. analysis of the beta-ureidopropionase gene (UPB1) of the first 4 patients presenting with a complete enzyme deficiency, revealed the presence of 2 splice-site mutations (IVS1-2A>G and IVS8-1G>A) and one missense mutation (A85E) PMID: 17065070

    顯示更多

    收起更多

  • 相關疾病:
    Beta-ureidopropionase deficiency (UPB1D)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Carbon-nitrogen hydrolase superfamily, BUP family
  • 組織特異性:
    Detected in liver (at protein level).
  • 數據庫鏈接:

    HGNC: 16297

    OMIM: 606673

    KEGG: hsa:51733

    STRING: 9606.ENSP00000324343

    UniGene: Hs.731656



主站蜘蛛池模板: 中文字幕乱码中文乱码777| 国产乱码二卡3卡四卡| 少妇无码太爽了不卡视频在线看 | 国产熟人av一二三区| 少妇人妻av毛片在线看| 香蕉精品亚洲二区在线观看| 亚洲成av人片在线观看橙子| 国产又黄又大又粗视频| 丰满人妻熟妇乱又伦精品软件| 99精品视频在线观看婷婷| 午夜香蕉成视频人网站| 国产精品喷浆| 成人欧美一区二区三区1314| 亚洲精品日本一区二区三区| 最新亚洲一卡二卡三卡四卡| 国产精品久久久久久av| 国产婷婷色一区二区三区在线| 国产精品青青在线观看爽| 欧洲美女熟乱av| 国产sm调教视频在线观看| 亚洲性色av一区二区三区| 婷婷综合久久狠狠色99h| 欧美日韩中文国产一区发布| 伊人久久大香线蕉av一区| 成人影院yy111111在线| 亚洲欧美日韩综合av| 无码熟妇人妻av在线影片| 永久免费的av在线电影网| 国产在线观看www污污污| 丁香婷婷综合激情五月色| 一出一进一爽一粗一大视频| 极品人妻被黑人中出种子| 国内自拍久久久久影院| 福利cosplayh裸体の福利| 伊人成年网站综合网| 丰满又黄又爽少妇毛片| 欧美丰满熟妇xxxx性| 国产亚洲成av人片在线观看| 免费看国产成年无码av| 国产精品免费大片| 好紧好爽好湿别拔出来视频男男|