在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human BRISC complex subunit Abro1 (FAM175B)

  • 中文名稱:
    Recombinant Human BRISC complex subunit Abro1(FAM175B)
  • 品名簡稱:
    Recombinant Human FAM175B protein
  • 貨號:
    CSB-EP619958HU
  • 說明書:
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    ABRAXAS2
  • Uniprot No.:
  • 別名:
    ABRAXAS2; ABRO1; FAM175B; KIAA0157BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    73.9kDa
  • 表達區域:
    1-415aa
  • 氨基酸序列
    MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPNNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage.
  • 基因功能參考文獻:
    1. In late S/G2 phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1/BRCC36-containing deubiquitinase complex. PMID: 27993934
    2. KIAA0157 allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity. PMID: 26344097
    3. ABRO1 is a novel p53 regulator that plays an important role in tumor suppression and the DNA damage response PMID: 25283148
    4. Study identified Abro1 as a specific interactor of THAP5, a zinc finger transcription factor that is involved in G2/M control and apoptosis. PMID: 21195082
  • 亞細胞定位:
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    FAM175 family, Abro1 subfamily
  • 組織特異性:
    Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain.
  • 數據庫鏈接:

    HGNC: 28975

    KEGG: hsa:23172

    STRING: 9606.ENSP00000298492

    UniGene: Hs.280695



主站蜘蛛池模板: 欧美精品黑人粗大破除| 奇米影视777四色狠狠| 亚洲成av人综合在线观看| 久久久无码精品午夜| 天天躁日日躁aaaxxⅹ| 中文无码日韩欧免费视频| 国产成人精品无码免费看夜聊软件| 高潮毛片无遮挡高清视频播放| 欧美成人看片一区二三区图文| 2021亚洲国产成a在线| 亚洲中文无码av在线| 久久无码av中文出轨人妻| 亚洲国产精品一区二区手机| 日韩免费无码专区精品观看| 情侣做性视频在线播放| 亚洲欧美丝袜精品久久| 国产av国内精品jk制服| 成人爽a毛片在线视频淮北| 国产欧美日韩va另类在线播放| 久久国产精品福利一区二区三区 | 奇米影视第4色| 狠狠色噜噜狠狠色综合久| 亚洲日韩a∨无码久| 亚洲欧美成aⅴ人在线观看| 蜜桃无码一区二区三区| 亚洲伊人成综合人影院青青青| 亚洲国产码专区| 精品久久人人爽天天玩人人妻| 亚洲另类无码专区国内精品| 丰满少妇aaaaaa爰片毛片| 亚洲熟妇丰满多毛xxxx| 美女av一区二区三区| 亚洲中文字幕不卡无码| 中文字幕一区在线观看视频| 久久久久无码精品国产不卡| 亚洲日韩性欧美中文字幕| 日本 精品 高清不卡| 69精品丰满人妻无码视频a片| 伊人大香人妻在线播放| av第一福利网站| 久久99精品久久只有精品|