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  4. Recombinant Human BPI fold-containing family B member 1 (BPIFB1)

Recombinant Human BPI fold-containing family B member 1 (BPIFB1)

  • 中文名稱：
    Recombinant Human BPI fold-containing family B member 1(BPIFB1)
  • 貨號：
    CSB-YP840572HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human BPI fold-containing family B member 1(BPIFB1)
  • 貨號：
    CSB-EP840572HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human BPI fold-containing family B member 1(BPIFB1)
  • 貨號：
    CSB-EP840572HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human BPI fold-containing family B member 1(BPIFB1)
  • 貨號：
    CSB-BP840572HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human BPI fold-containing family B member 1(BPIFB1)
  • 貨號：
    CSB-MP840572HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    BPIFB1
  • Uniprot No.：
  • 別名：
    BPIFB1; C20orf114; LPLUNC1; UNQ706/PRO1357BPI fold-containing family B member 1; Long palate; lung and nasal epithelium carcinoma-associated protein 1; von Ebner minor salivary gland protein; VEMSGP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    22-484
  • 氨基酸序列
    TLSPTAVLI LGPKVIKEKL TQELKDHNAT SILQQLPLLS AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK PSANDQELLV KIPLDMVAGF NTPLVKTIVE FHMTTEAQAT IRMDTSASGP TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL AKQVMNLLVP SLPNLVKNQL CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK GDTIQLYLGA KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI DQGHAKVAQL IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN NISSDRIQLM NSGIGWFQPD VLKNIITEII HSILLPNQNG KLRSGVPVSL VKALGFEAAE SSLTKDALVL TPASLWKPSS PVSQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.
  • 基因功能參考文獻：
    1. BPIFA1 and BPIFB1 expressions are correlated with goblet cell metaplasia and inversely correlated with lung function parameters of airway obstruction (FEV1 and FEV1/FVC) in COPD patients. PMID: 29296079
    2. The G allele of rs1078761 may be detrimental to lung function in cystic fibrosis owing to decreased levels of BPIFA1 and BPIFB1. PMID: 25574903
    3. higher sputum concentrations of BPIFB1 were associated with changes of lung function over time, especially in current smokers with chronic obstructive pulmonary disease. BPIFB1 may be involved in the pathogenesis of smoking-related lung diseases. PMID: 25979078
    4. Autoimmunity targeting the lung-specific antigen BPIFB1 may contribute to the pathogenesis of interstitial lung disease. PMID: 24107778
    5. Results suggest that LPLUNC1 can inhibit inflammation and nasopharyngeal carcinoma (NPC) growth by downregulating the Stat3 pathway. PMID: 23708661
    6. LPLUNC1 delays nasopharyngeal carcinoma cell growth by inhibiting the MAP Kinase and cyclin D1/E2F pathways. PMID: 23650533
    7. It was shown that there was a significant increase in LPLUNC1 in the airways of patients with cystic fibrosis, but it is unclear if this increase influences the development of lung disease. PMID: 22767025
    8. These results demonstrate that LPLUNC1 is expressed in Paneth cells and likely plays a role in modulating host inflammatory responses to Vibrio cholerae infection. PMID: 21900486
    9. LPLUNC1 is an abundant, secreted product of goblet cells and minor mucosal glands of the respiratory tract and oral cavity and suggest that the protein functions in the complex milieu that protects the mucosal surfaces in these locations. PMID: 20237794
    10. LPLUNC1 is found to be down-expressed in 33 of 48 nasopharyngeal carcinoma biopsies. PMID: 12874788
    11. We found a significant association of cholera with a marker in the promoter region of LPLUNC1 (rs11906665), a member of a family of evolutionarily conserved innate immunity proteins PMID: 19212328

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    BPI/LBP/Plunc superfamily, Plunc family
  • 組織特異性：
    Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung.
  • 數據庫鏈接：

    HGNC: 16108

    KEGG: hsa:92747

    STRING: 9606.ENSP00000253354

    UniGene: Hs.65551



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