在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1), partial

Recombinant Human Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1), partial

  • 中文名稱：
    人NCR3LG1重組蛋白
  • 貨號：
    CSB-YP737873HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NCR3LG1重組蛋白
  • 貨號：
    CSB-EP737873HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NCR3LG1重組蛋白
  • 貨號：
    CSB-MP737873HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    NCR3LG1; B7H6; Natural cytotoxicity triggering receptor 3 ligand 1; B7 homolog 6; B7-H6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Triggers NCR3-dependent natural killer cell activation.
  • 基因功能參考文獻：
    1. B7-H6 was expressed in gliomas and correlated with glioma progression. Knockdown of B7-H6 inhibited glioma cell proliferation, colony formation, migration, and invasion via upregulation of E-cadherin and Bax, and downregulation of vimentin, N-cadherin, MMP-2, MMP-9 and survivin. PMID: 29679856
    2. these studies find that soluble B7H6 is constitutively expressed during pregnancy PMID: 29055565
    3. Data suggest that B7-H6 play an important role in the regulation of the biological behavior of glioma cells. PMID: 28415577
    4. Data indicate a sequence of events driven by tumour-derived prostaglandin D2 (PGD2) associated with engagement of the natural cytotoxicity triggering receptor 3 (NKp30)-B7H6 antigen (B7H6) pathway leading to significant group 2 innate lymphoid cells (ILC2s) activation and expansion. PMID: 28928446
    5. B7H6-derived peptides trigger TNF-alpha-dependent immunostimulatory activity of lymphocytic NK92-MI cells. PMID: 27216712
    6. Study confirms that B7-H6 is widely expressed in B-cell lymphomas and demonstrates its important role in the pathogenesis and chemosensitivity of lymphoma. PMID: 26891663
    7. our present data revealed that higher B7-H6 expression in ovarian cancer tissues was positively correlated with tumor metastasis and cancer progression PMID: 26464699
    8. NKp30-B7-H6 interaction is a novel cell contact mechanism that mediates activation of Group 2 innate lymphoid cells and identifies a potential target for the development of novel therapeutics for atopic dermatitis and other atopic diseases. PMID: 26582946
    9. study not only reveals the possibility that tumor therapeutics work as stress inducers to enhance tumor sensitivity to NK cell cytolysis but also suggests that B7-H6 could be a potential target for tumor therapy in the future PMID: 26472927
    10. Our results suggest that NKP30-B7-H6 interaction can aggravate hepatocyte damage, probably through up-regulation of IL-32 expression in hepatitis B virus-related acute-on-chronic liver failure PMID: 26241657
    11. the interaction between NKp30 and B7-H6 may contribute to the fate of neuroblastoma patients PMID: 25877893
    12. Study suggests that B7-H6 has a limited value as a prognostic marker in non-small cell lung cancer patients. PMID: 25400778
    13. this study identified ectodomain shedding of B7-H6 by the metalloproteases "a disintegrin and metalloproteases" (ADAM)-10 and ADAM-17 from the cell surface of tumor cells as a crucial mechanism of expression regulation of B7-H6. PMID: 24780758
    14. B7-H6-positive carcinomas were significantly associated with a higher differentiation. PMID: 24242703
    15. Allogeneic and xenogeneic anti-tumor effect of callithrix jacchus natural killer cells is dependent on NKp30 and B7-H6 interaction. PMID: 25001651
    16. Data indicate that the ectodomain of NKp30 forms functional homo-oligomers that mediate high affinity binding to its corresponding cellular ligand B7-H6. PMID: 24275655
    17. These findings reveal that B7-H6 is not only implicated in tumor immunosurveillance but also participates in the inflammatory response in infectious conditions. PMID: 23687088
    18. B7-H6:7D8 represents the first Ab-based molecule stimulating NKp30-mediated NK cell cytotoxicity for therapeutic purposes PMID: 23066150
    19. The NKp30-B7-H6 structure revealed that this NK cell activating complex is distinct from the CTLA4-B7 and PD-1-PD-L T cell inhibitory complexes in both overall organization and detailed atomic interactions that mediate binding and specificity. PMID: 21422170
    20. DKFZp686O24166 was designated the gene B7-H6; identification as a tumor cell surface molecule that binds NKp30, a receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion PMID: 19528259

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level).
  • 數據庫鏈接：

    HGNC: 42400

    OMIM: 613714

    KEGG: hsa:374383

    STRING: 9606.ENSP00000341637

    UniGene: Hs.146274



主站蜘蛛池模板： 精品无人乱码高清| 少妇高潮太爽了在线观看| 久久九九兔免费精品6| 亚洲深深色噜噜狠狠网站| 亚洲日韩一区精品射精| 国产精品9999久久久久仙踪林| 亚洲国产成人久久综合下载| av不卡国产在线观看| 中文无码天天av天天爽| 人妻久久久一区二区三区| 国产日韩欧美亚洲精品中字 | 大胸美女被吃奶爽死视频| 俄罗斯丰满熟妇hd| 亚洲精品久久久无码av片软件| 青娱国产区在线| 亚洲熟妇自偷自拍另类| 曰韩无码av片免费播放不卡| 欧美成aⅴ人高清怡红院| 337p日本欧洲亚洲大胆精筑| 人妻无码第一区二区三区| 国产成人亚洲精品狼色在线| 12裸体自慰免费观看网站| av无码天一区二区一三区| 国产精品亚洲αv天堂无码| 3p人妻少妇对白精彩视频| 欧美精品亚洲精品日韩专区| 中文字幕有码无码人妻av蜜桃| 亚洲一区二区观看播放| 午夜精品久久久久久久四虎| 欧美日韩亚洲国产在线制服| 午夜家庭影院| 国产一区二区野外| 亚洲国产aⅴ综合网| 亚洲熟妇av一区二区三区漫画| 国产suv精品一区二区6| 欧美日韩在手机线旡码可下载| 精品久久久无码中文字幕天天 | av国産精品毛片一区二区网站| 2021久久国自产拍精品| 日本三级在线观看免费| 野外少妇被弄到喷水在线观看 |