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  4. Recombinant Human B-cell scaffold protein with ankyrin repeats (BANK1)

Recombinant Human B-cell scaffold protein with ankyrin repeats (BANK1)

  • 中文名稱：
    Recombinant Human B-cell scaffold protein with ankyrin repeats(BANK1)
  • 貨號：
    CSB-EP836722HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human B-cell scaffold protein with ankyrin repeats(BANK1)
  • 貨號：
    CSB-EP836722HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human B-cell scaffold protein with ankyrin repeats(BANK1)
  • 貨號：
    CSB-BP836722HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human B-cell scaffold protein with ankyrin repeats(BANK1)
  • 貨號：
    CSB-MP836722HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Name:BANK1
  • Uniprot No.：
  • 別名：
    BANK1B-cell scaffold protein with ankyrin repeats
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-785
  • 氨基酸序列
    MLPAAPGKGL GSPDPAPCGP APPGNTKDII MIYEEDAEEW ALYLTEVFLH VVKREAILLY RLENFSFRHL ELLNLTSYKC KLLILSNSLL RDLTPKKCQF LEKILHSPKS VVTLLCGVKS SDQLYELLNI SQSRWEISTE QEPEDYISVI QSIIFKDSED YFEVNIPTDL RAKHSGEISE RKEIEELSEA SRNTIPLAVV LPTEIPCENP GEIFIILRDE VIGDTVEVEF TSSNKRIRTR PALWNKKVWC MKALEFPAGS VHVNVYCDGI VKATTKIKYY PTAKAKECLF RMADSGESLC QNSIEELDGV LTSIFKHEIP YYEFQSLQTE ICSQNKYTHF KELPTLLHCA AKFGLKNLAI HLLQCSGATW ASKMKNMEGS DPAHIAERHG HKELKKIFED FSIQEIDINN EQENDYEEDI ASFSTYIPST QNPAFHHESR KTYGQSADGA EANEMEGEGK QNGSGMETKH SPLEVGSESS EDQYDDLYVF IPGADPENNS QEPLMSSRPP LPPPRPVANA FQLERPHFTL PGTMVEGQME RSQNWGHPGV RQETGDEPKG EKEKKEEEKE QEEEEDPYTF AEIDDSEYDM ILANLSIKKK TGSRSFIINR PPAPTPRPTS IPPKEETTPY IAQVFQQKTA RRQSDDDKFC GLPKKQDRAR IESPAFSTLR GCLTDGQEEL ILLQEKVKNG KMSMDEALEK FKHWQMGKSG LEMIQQEKLR QLRDCIIGKR PEEENVYNKL TIVHHPGGKE TAHNENKFYN VHFSNKLPAR PQVEKEFGFC CKKDH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.
  • 基因功能參考文獻：
    1. Our data defines a minimal set of risk associated eQTLs predicted to be involved in the expression of BANK1 modulated through epigenetic regulation and splicing. These findings allow us to suggest that the increased expression of BANK1 will have an impact on B-cell mediated disease pathways. PMID: 30096841
    2. our results indicated that the BLK rs13277113 polymorphism was involved in the genetic background of RA in Chinese population and the association of BANK1 rs3733197 polymorphism with RA was dependent on the genotype of BLK rs13277113 polymorphism, highlighting B-cell response implicated in the pathogenesis of RA. PMID: 28925718
    3. This meta-analysis demonstrates that BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms are associated with susceptibility to autoimmune diseases. PMID: 28466820
    4. Confirm the association of rs548234/ATG5, rs2736340/BLK and rs10516487/BANK1 with systemic lupus erythematosus in Chinese Han and reinforced our hypothesis of their epistasis effect in regulating B-cell signaling in SLE. PMID: 26420661
    5. The results of this study suggesting a mechanism for the involvement of BANK1 in the BOLD response to working memory PMID: 27671502
    6. Single-nucleotide polymorphism in BANK1 gene is associated with sclerotic graft-versus-host disease. PMID: 27313329
    7. The SLE susceptibility variants in the BANK1 gene may contribute to lupus by altering B cell signaling, increasing FOXO1 levels, and enhancing memory B cell development PMID: 27816669
    8. The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function. PMID: 26821283
    9. Data show that single-nucleotide polymorphism rs3733197 located in the coding region of BANK1 (B-cell scaffold protein with ankyrin repeats 1) was significantly associated with serum LDL cholesterols. PMID: 25608828
    10. Authors identified a novel balanced reciprocal translocation, t(4;14)(q24;q32.) Sequence analysis identified the partner gene as BANK1. PMID: 24879116
    11. Our study confirms evidence for epistasis between BLK and BANK1 in systemic lupus erythematosis from a Chinese population for the first time. PMID: 24085759
    12. Our findings suggest the existence of association between BANK1 gene and autoimmune thyroid diseases PMID: 24127308
    13. BANK1 and IL15 as new T1D genetic susceptibility factors. PMID: 24342660
    14. BANK1 and BLK have roles in B-cell signaling through phospholipase C gamma 2 PMID: 23555801
    15. SNPs of the FAM167A-BLK region, but not the BANK1 SNPs, were associated with the development of primary Sjogren's syndrome in Han Chinese. PMID: 23899688
    16. This study confirms BANK1 as an RA susceptibility gene and for the first time provides evidence for epistasis between BANK1 and BLK in RA. PMID: 23646104
    17. This study did not reveal a major role for BANK1 in humoral autoimmunity in chronic arthritis. PMID: 23065315
    18. short Delta2 isoform of BANK1 displays a homogeneous cytoplasmic distribution PMID: 21900951
    19. Polymorphism in BANK1 is associated with susceptibility to psoriasis in Southern Han Chinese. PMID: 21989138
    20. allelic variation in BANK1 does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
    21. This study implies that rs10516487 and rs17266594 polymorphisms might contribute to individual susceptibility to SLE PMID: 21078628
    22. This study shows a genetic interaction between BANK1 and BLK, and demonstrates that these molecules interact physically. PMID: 21978998
    23. This meta-analysis demonstrates a significant association between BANK1 and TNFAIP3 gene polymorphism and systemic lupus erythematosus in multiple ethnic populations. PMID: 21208380
    24. Results do not support a major implication of the BANK1 locus in susceptibility to giant cell arteritis. PMID: 20472928
    25. results suggest that the BANK1 gene confers susceptibility to systemic sclerosis in general, and specifically to the diffuse cutanenous systemic sclerosis and anti-topoisomerase I antibody subsets. PMID: 19815934
    26. Functional variants in the B-cell gene BANK1 are assoicated with systemic lupus erythematosus. PMID: 18204447
    27. These results suggest that BANK1 SNPs and haplotypes may contribute to rheumatoid arthritis susceptibility with a low risk. PMID: 19180476
    28. Study independently replicates and confirms the strong association of BANK1 variants rs17266594 and rs10516487 with the risk of systemic lupus erythematosus in the European-derived population. PMID: 19339986
    29. Study confirmed the associations of BANK1 (rs3733197)and TNFSF4 (rs844648) with systemic lupus erythematosus in Hong Kong Chinese. PMID: 19357697
    30. STAT4 and BLK displayed a strong genetic association with primary antiphospholipid syndrome, while a weak association with IRF5 and no association with BANK1 were observed. PMID: 19644876
    31. BANK1 is a new systemic sclerosis genetic susceptibility factor. BANK1, IRF5, and STAT4 act with additive effects. PMID: 19877059

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  • 相關疾病：
    Systemic lupus erythematosus (SLE)
  • 組織特異性：
    Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19(+) B-cells, with very low expression in other cell populations.
  • 數據庫鏈接：

    HGNC: 18233

    OMIM: 152700

    KEGG: hsa:55024

    STRING: 9606.ENSP00000320509

    UniGene: Hs.480400



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