在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Autophagy-related protein 2 homolog A (ATG2A), partial

  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog A(ATG2A) ,partial
  • 貨號:
    CSB-YP648779HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog A(ATG2A) ,partial
  • 貨號:
    CSB-EP648779HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog A(ATG2A) ,partial
  • 貨號:
    CSB-EP648779HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog A(ATG2A) ,partial
  • 貨號:
    CSB-BP648779HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog A(ATG2A) ,partial
  • 貨號:
    CSB-MP648779HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    1810013C15Rik; A830054M12; ATG2 autophagy related 2 homolog A (S. cerevisiae); ATG2A; ATG2A_HUMAN; Autophagy-related protein 2 homolog A; BC023754; KIAA0404; MGC117153; MGC67447; mKIAA0404
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell.
  • 基因功能參考文獻:
    1. Authors demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC). PMID: 28800131
    2. Among polymorphisms identified in the present study, rs76974938 [C/T (D67N)] of C21orf59 and rs188780113 [G/A (R478C)] of ATG2A may be novel determinants of estimated glomerular filtration rate and chronic kidney disease or of the serum concentration of uric acid, respectively. PMID: 28410202
    3. The N-terminal amino acids 1-198 and the C-terminal amino acids 1830-1938 are required for the localization to isolation membranes and lipid droplets, respectively. We also identified an amphipathic helix in ATG2A that is required for both its localization to organelles and autophagosome formation. PMID: 29113029
    4. Depletion of both Atg2A and Atg2B causes clustering of enlarged lipid droplets in an autophagy-independent manner. These data suggest that mammalian Atg2 proteins function both in autophagosome formation and regulation of lipid droplet morphology and dispersion. PMID: 22219374
    5. human hAtg2A can not function in autophagy in yeast, however, it is recruited to the preautophagosomal structure PMID: 21887408

    顯示更多

    收起更多

  • 亞細胞定位:
    Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族:
    ATG2 family
  • 數據庫鏈接:

    HGNC: 29028

    OMIM: 616225

    KEGG: hsa:23130

    STRING: 9606.ENSP00000366475

    UniGene: Hs.370671



主站蜘蛛池模板: 国产69精品久久久久久久| 亚洲国产精品国语在线| 久久久久无码精品国产不卡| 亚洲日韩中文无码久久| 欧美性欧美巨大黑白大战| 亚洲在av极品无码天堂手机版| 伊人久久大香线蕉综合5g| 校花高潮抽搐冒白浆| 粗大的内捧猛烈进出视频| 成人性生交大片免费看中文| 俺也来俺也去俺也射| 综合激情丁香久久狠狠| 爆乳护士一区二区三区在线播放 | 国产熟妇按摩3p高潮大叫 | 少妇放荡的呻吟干柴烈火免费视频| 国产成人无码18禁午夜福利p| 免费男人下部进女人下部视频| 久久亚洲中文字幕精品一区| 欲色影视天天一区二区色香欲| 国产亚洲精品久久久闺蜜| 精品久久久无码中文字幕| 中文字幕无线码一区2020青青| 中国熟妇牲交视频免费| 国产美女口爆吞精普通话| 欧美精品videosbestsex日本| 久久久久99精品成人片三人毛片 | 爽爽午夜影视窝窝看片| 国产精品55夜色66夜色| av小次郎收藏| 午夜精品国产精品大乳美女| 免费人成在线观看网站品善网| 国产欧美日韩综合在线成| 国产精品禁18久久久夂久| 丁香激情综合久久伊人久久| 欧美激情精品久久久久久| 亚洲经典国产精华液单品榜| 制服丝袜亚洲中文欧美在线| 天堂网www在线资源网| 尤物视频在线观看| 精品无码中文字幕在线| 国产女人抽搐喷浆视频|