在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Arylacetamide deacetylase (AADAC), partial

In Stock
  • 中文名稱:
    Recombinant Human Arylacetamide deacetylase(AADAC),partial
  • 貨號:
    CSB-EP001014HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP001014HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AADAC.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP001014HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AADAC.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    AADAC
  • Uniprot No.:
  • 別名:
    AAAD_HUMAN; Aada; Aadac; Arylacetamide deacetylase (esterase); Arylacetamide deacetylase; CES5A1; DAC
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    partial
  • 來源:
    E.coli
  • 分子量:
    63.1kDa
  • 表達區域:
    24-399aa
  • 氨基酸序列
    PDNVEEPWRMMWINAHLKTIQNLATFVELLGLHHFMDSFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKSEALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLFLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFVNWSSLLPERFIKGHVYNNPNYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述:

    E.coli expressed Recombinant Human Arylacetamide deacetylase(AADAC) is a partial-length protein containing 376 amino acids. It carries a 10xHis-SUMO-tag at the N-terminus and a Myc-tag at the C-terminus. Its expression region is the 24-399aa of the human AADAC protein. The LC-MS/MS Analysis validated its identity and SDS-PAGE determined its purity. Its purity is greater than 90%. This protein is in-stock so that it will reach your lab bench faster. In addition to serving as an immunogen for antibody synthesis, the recombinant AADAC protein may also be used to investigate whether it is involved in the breakdown of certain drugs.

    AADAC is a serine hydrolase that widely catalyzes the hydrolysis of some clinically used drugs. AADAC is primarily expressed in the human intestine and liver and is responsible for the hydrolysis of flutamide, phenacetin, and rifampicin. It is closely related to kidney failure and hepatotoxicity in some patients after taking flutamide or phenacetin.

  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
  • 基因功能參考文獻:
    1. that the AADAC gene c.361+1G>A variant may be a potential candidate factor for Tourette syndrome development PMID: 29253601
    2. Data suggest that AADAC in hepatocyte microsomes hydrolyzes ketoconazole, a synthetic imidazole antifungal agent, to N-deacetyl ketoconazole and thus triggers hepatocellular toxicity. PMID: 27422753
    3. AADAC deletion is a candidate susceptibility factor for Gilles de la Tourette Syndrome PMID: 26444075
    4. Translational N-glycosylation of AADAC plays a crucial role in regulating AADAC enzyme activity. PMID: 24125761
    5. Lipolysis of cellular TG and VLDL production were impaired in HCV infected cells during the early peak of viral infection. This was partially explained by an apparent deficiency of a putative TG lipase, arylacetamide deacetylase (AADAC). PMID: 23542347
    6. An AADAC*3 allele yields decreased enzyme activity in liver microsomes. PMID: 22415931
    7. human AADAC was the enzyme responsible for the deacetylation of rifamycins and would affect the induction rate of drug-metabolizing enzymes by rifamycins and their induced hepatotoxicity. PMID: 21856291
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    9. two intrinsic endoplasmic reticulum (ER) proteins, 11beta-hydroxysteroid dehydrogenase, isozyme 1 (11beta-HSD) and the 50-kDa esterase (E3), sharing some amino acid sequence motifs in their N-terminal transmembrane (TM) domains. PMID: 10318829

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    'GDXG' lipolytic enzyme family
  • 組織特異性:
    Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.
  • 數據庫鏈接:

    HGNC: 17

    OMIM: 600338

    KEGG: hsa:13

    STRING: 9606.ENSP00000232892

    UniGene: Hs.506908



主站蜘蛛池模板: 乱人伦中文无码视频| 国产午夜aaaaa片在线影院| 人妻无码vs中文字幕久久av爆| 久久国产福利国产秒拍飘飘网| 国产无套中出学生姝| 四虎永久在线精品免费网站 | 久久天天躁狠狠躁夜夜av浪潮| 国产精品 中文字幕 亚洲 欧美| 天堂а在线中文在线新版| 久久婷婷五月综合色一区二区| 亚洲综合色婷婷七月丁香| 琪琪午夜理论片福利在线观看| 精品人妻系列无码一区二区三区| 中文字幕乱码人妻二区三区| 饥渴少妇做私密保健视频| 最大胆裸体人体牲交免费| 成人片黄网站色大片免费毛片| 韩国精品一区二区三区四区 | 狠狠亚洲色一日本高清色| 日韩精品久久久久久免费| 久久精品午夜福利| 99麻豆久久久国产精品免费| 亚洲欧洲免费三级网站| 97国产色伦在色在线播放| 国产乱色国产精品播放视频| 成熟丰满熟妇高潮xxxxx视频| 欧美制服丝袜人妻另类| 天天狠天天添日日拍| 中出内射颜射骚妇| 中文字幕日本最新乱码视频| 国产成 人 综合 亚洲网站| 131mm少妇做爰视频| 好爽…又高潮了毛片免费看| 国自产拍偷拍精品啪啪模特| 最新国产精品精品视频| 国产乱码二卡3卡四卡| 少妇特黄a一区二区三区| 中文在线а天堂| 亚洲日本乱码一区二区产线一∨ | 国产精品毛片va一区二区三区| 免费看成人午夜福利专区|