在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Arrestin domain-containing protein 3 (ARRDC3)

Recombinant Human Arrestin domain-containing protein 3 (ARRDC3)

  • 中文名稱(chēng)：
    Recombinant Human Arrestin domain-containing protein 3(ARRDC3)
  • 貨號(hào)：
    CSB-YP839293HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Human Arrestin domain-containing protein 3(ARRDC3)
  • 貨號(hào)：
    CSB-EP839293HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Human Arrestin domain-containing protein 3(ARRDC3)
  • 貨號(hào)：
    CSB-EP839293HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    Recombinant Human Arrestin domain-containing protein 3(ARRDC3)
  • 貨號(hào)：
    CSB-BP839293HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Human Arrestin domain-containing protein 3(ARRDC3)
  • 貨號(hào)：
    CSB-MP839293HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARRDC3
  • Uniprot No.：
  • 別名：
    ARRDC3; KIAA1376; Arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; TLIMP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-414
  • 氨基酸序列
    MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFHTIHSGRH EYAFSFELPQ TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT LCCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLSLSLP ERPEAPPSYA EVVTEEQRRN NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQSADDRPS CPSR
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.
  • 基因功能參考文獻(xiàn)：
    1. correlation analysis indicated that the expression of ARRDC3 was negatively correlated with ITGbeta4 in clinical prostate cancer (PCa) tissues and cell lines. Our data revealed that ARRDC3 can serve as a tumor suppressor to inhibit PCa progression and an independent marker to predict the risk of biochemical recurrence and metastasis after radical resection of PCa. PMID: 28782483
    2. For the in vivo experiment, miR-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR-182-5p may be a key androgen receptor-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer. PMID: 27109471
    3. ARRDC3 functions as a switch to modulate the endosomal residence time and subsequent intracellular signaling of the beta2AR PMID: 27226565
    4. We found that ARRDC3 is required for ALIX ubiquitination induced by activation of PAR1 PMID: 26490116
    5. Promoter hypermethylation is an important mechanism of the transcriptional inactivation of ARRDC3 in invasive ductal breast carcinoma. PMID: 25148870
    6. The ARRDC3 is one of six known human alpha-arrestins, and has been implicated in the downregulation of the beta2-adrenergic receptor (beta2AR). PMID: 25220262
    7. High affinity binding of full-length ARRDC3 and Nedd4 is driven by the avid interaction of both PPXY motifs with either the WW2-WW3 or WW3-WW4 combinations. PMID: 24379409
    8. Beta 2 adrenergic receptor endocytosis requires beta-arrestin2 but not ARRDC3. PMID: 23208550
    9. single-nucleotide polymorphisms in ARRDC3, FLT1, and SKAP1 were significant predictors for survival androgen-deprivation therapy in prostate cancer patients. PMID: 21652578
    10. The obesity risk locus contains a single gene, arrestin domain-containing 3 (ARRDC3), which interacts directly with beta-adrenergic receptors and is gender-specific. PMID: 21982743
    11. Data show that ARRDC3 interacts with NEDD4 through two conserved PPXY motifs and recruits NEDD4 to the activated beta2-adrenergic receptor. PMID: 20559325
    12. ARRDC3 directly binds to a phosphorylated form of ITGbeta4 leading to its internalization, ubiquitination and ultimate degradation, and suppress breast cancer progression. PMID: 20603614
    13. [Thioredoxin-binding protein-2-like inducible membrane protein, TLIMP] TLIMP, a novel VD3- or PPARgamma ligand-inducible membrane-associated protein, plays a regulatory role in cell proliferation and PPARgamma activation. PMID: 16269462
    14. Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins PMID: 19605364

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Endosome. Early endosome.
  • 蛋白家族：
    Arrestin family
  • 組織特異性：
    Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentia
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29263

    OMIM: 612464

    KEGG: hsa:57561

    STRING: 9606.ENSP00000265138

    UniGene: Hs.24684



主站蜘蛛池模板： 久久久久人妻一区精品性色av| 精品国产一区二区三区国产区| 国产午夜无码福利在线看网站| av东京热无码专区| 中国丰满人妻videoshd| 一本大道av伊人久久综合| 少妇挑战黑人高潮惨叫| 麻婆豆传媒一区二区三区| 亚洲精品久久久久中文字幕m男 | 人妻综合专区第一页| 亚洲国产日韩a在线播放| 白嫩少妇激情无码| 亚洲午夜福利在线观看| √最新版天堂资源在线| 亚洲国产剧情中文视频在线| 日产精品卡2卡三卡乱码网址 | 精品无码国产av一区二区| 亚洲精品久久久久中文第一幕| 亚洲欧洲无码av电影在线观看| 亚洲人成电影免费观看在线看| 亚欧av无码乱码在线观看性色| 狠狠躁天天躁夜夜躁婷婷| 久久人人爽人人爽人人片av麻烦 | 七七久久成人影院网站| 亚洲欧美偷拍另类a∨| 久9热视频这里只精品18| 无码人妻精品一区二区三区9厂| 婷婷开心激情综合五月天| 色先锋影音岛国av资源| 中文字幕精品一二三四五六七八| 精品午夜福利1000在线观看| 天堂网在线最新版www中文网| 两性色午夜视频免费老司机| 中文国产成人精品久久app | 夜夜爱夜鲁夜鲁很鲁| 少妇激情一区二区三区视频小说| 国产乱子经典视频在线观看| 国产69精品久久久久乱码| 亚洲乱码伦小说区| 精品少妇人妻av一区二区三区| 欧美极品video粗暴|