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  4. Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1), partial

Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1), partial

  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(ARAP1) ,partial
  • 貨號：
    CSB-YP856998HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(ARAP1) ,partial
  • 貨號：
    CSB-EP856998HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(ARAP1) ,partial
  • 貨號：
    CSB-EP856998HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(ARAP1) ,partial
  • 貨號：
    CSB-BP856998HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(ARAP1) ,partial
  • 貨號：
    CSB-MP856998HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    2410002L19Rik; ANK repeat and PH domain-containing protein 1; ARAP 1; Arap1; ARAP1_HUMAN; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1; Arf-GAP with Rho-GAP domain; CENT D2; Centaurin delta 2; Centaurin delta2; Centaurin-delta-2; CENTD 2; CENTD2; Cnt d2; Cnt-d2; Cntd2; KIAA0782; MGC176140; mKIAA0782
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.
  • 基因功能參考文獻：
    1. Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression. PMID: 28132686
    2. Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population. PMID: 25749274
    3. The proinsulin-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets. PMID: 24439111
    4. a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway. PMID: 22573888
    5. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. PMID: 22357923
    6. Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release. PMID: 21267535
    7. ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking PMID: 21275903
    8. PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells. PMID: 20554524
    9. ARAP1 acts primarily on Arf6 in vivo. PMID: 18003747
    10. ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death. PMID: 18165900
    11. ARAP1 controls the late steps of the endocytic trafficking of the EGF-R PMID: 18764928
    12. ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation PMID: 18939958
    13. Data suggest that ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P(3), the subsequent production of which triggers enzymatic activity. PMID: 19666464

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  • 亞細胞定位：
    Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
  • 組織特異性：
    Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.
  • 數據庫鏈接：

    HGNC: 16925

    OMIM: 606646

    KEGG: hsa:116985

    STRING: 9606.ENSP00000377233

    UniGene: Hs.503165



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