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  4. Recombinant Human Anoctamin-6 (ANO6), partial

Recombinant Human Anoctamin-6 (ANO6), partial

  • 中文名稱：
    Recombinant Human Anoctamin-6(ANO6) ,partial
  • 貨號：
    CSB-YP679761HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-6(ANO6) ,partial
  • 貨號：
    CSB-EP679761HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-6(ANO6) ,partial
  • 貨號：
    CSB-EP679761HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-6(ANO6) ,partial
  • 貨號：
    CSB-BP679761HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-6(ANO6) ,partial
  • 貨號：
    CSB-MP679761HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    2900059G15Rik; AA407480; Ano6; ANO6_HUMAN; Anoctamin 6; Anoctamin-6; AW554778; BDPLT7; F730003B03Rik; MGC104751; SCTS; TMEM16F; Transmembrane protein 16F
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
  • 基因功能參考文獻：
    1. ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6. PMID: 28125837
    2. TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT signaling pathways. PMID: 27287741
    3. Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms PMID: 26108457
    4. deficiency in Ano6 resulted in reduced viability with increased bleeding time PMID: 26481309
    5. ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. PMID: 26448322
    6. Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets. PMID: 26057829
    7. Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. PMID: 25651887
    8. using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID: 25589784
    9. Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor), but not during mitochondrial apoptosis. PMID: 23618909
    10. a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population PMID: 23308121
    11. TMEM16F is an essential component of a divalent calcium ion-activated Cl- channel with a divalent calcium ion sensitivity that is distinct from that of TMEM16A/B and not related to volume-sensitive outwardly rectifying Cl- channel (VSOR) activity. PMID: 23426967
    12. It scrambles phospholipids in cell membrane and its mutation leads to Scott syndrome. (review) PMID: 22256604
    13. Study identified 2 novel mutations in the TMEM16F gene in 2 patients with Scott syndrome. PMID: 21511967
    14. Wild-type TMEM16F was localized on the plasma membrane and conferred Ca(2+)-dependent scrambling of phospholipids PMID: 21107324

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  • 相關(guān)疾病：
    Scott syndrome (SCTS)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693.
  • 蛋白家族：
    Anoctamin family
  • 組織特異性：
    Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25240

    OMIM: 262890

    KEGG: hsa:196527

    STRING: 9606.ENSP00000409126

    UniGene: Hs.505339



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