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  4. Recombinant Human Anoctamin-10 (ANO10), partial

Recombinant Human Anoctamin-10 (ANO10), partial

  • 中文名稱：
    Recombinant Human Anoctamin-10(ANO10),partial
  • 貨號：
    CSB-YP873667HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-10(ANO10),partial
  • 貨號：
    CSB-EP873667HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-10(ANO10),partial
  • 貨號：
    CSB-EP873667HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-10(ANO10),partial
  • 貨號：
    CSB-BP873667HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Anoctamin-10(ANO10),partial
  • 貨號：
    CSB-MP873667HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ANO10
  • Uniprot No.：
  • 別名：
    ANO10; TMEM16KAnoctamin-10; Transmembrane protein 16K
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
  • 基因功能參考文獻(xiàn)：
    1. This study describe 2 Romani families from Serbia presenting with seemingly dominant (multiple affected individuals in successive generations) cerebellar ataxia, both harboring the same homozygous (recessive) mutation in ANO10, identified by whole-exome sequencing. PMID: 27787937
    2. mutations in ANO10 cause cellular defects and genetic disorders through deranged local Ca(2+) signaling. PMID: 27838374
    3. results suggest that executive and attentional disorders are impaired in ANO10 mutation PMID: 27045840
    4. ANO10 has a central role in innate immune defense against Borrelia infection. PMID: 25730773
    5. The detection of mutations in ANO10 indicate that ANO10 defects cause secondary low coenzyme Q10. PMID: 25182700
    6. An ANO10 mutation is responsible for autosomal recessive cerebellar ataxia that is mainly characterized by cerebellar atrophy and lack of peripheral neuropathy. PMID: 25089919
    7. Whole-exome and targeted sequencing have defined the genetic basis of dizziness including new genes causing ataxia: GBA2, TGM6, ANO10 and SYT14 PMID: 24275721
    8. This study report Gypsy family with autosomal recessive ataxia caused by the same truncating ANO10 defect. PMID: 22008874
    9. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing ANO10 genes causing ataxia. PMID: 22527681

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  • 相關(guān)疾病：
    Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
  • 蛋白家族：
    Anoctamin family
  • 組織特異性：
    Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lo
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25519

    OMIM: 613726

    KEGG: hsa:55129

    STRING: 9606.ENSP00000292246

    UniGene: Hs.656657



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