在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Alkaline ceramidase 2 (ACER2), partial

Recombinant Human Alkaline ceramidase 2 (ACER2), partial

  • 中文名稱：
    Recombinant Human Alkaline ceramidase 2(ACER2),partial
  • 貨號：
    CSB-YP001152HU1
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Alkaline ceramidase 2(ACER2),partial
  • 貨號：
    CSB-EP001152HU1
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Alkaline ceramidase 2(ACER2),partial
  • 貨號：
    CSB-EP001152HU1-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Alkaline ceramidase 2(ACER2),partial
  • 貨號：
    CSB-BP001152HU1
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Alkaline ceramidase 2(ACER2),partial
  • 貨號：
    CSB-MP001152HU1
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ACER2
  • Uniprot No.：
  • 別名：
    ACER2; ASAH3L; PP11646; Alkaline ceramidase 2; AlkCDase 2; Alkaline CDase 2; haCER2; Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides. Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates. Also hydrolyzes dihydroceramides to produce dihydrosphingosine. It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells. Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate. As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage. Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins.
  • 基因功能參考文獻：
    1. Consistently, forced expression of p53 significantly stimulated ACER2 transcription. Notably, p53-mediated autophagy and apoptosis were markedly enhanced by ACER2. Depletion of the essential autophagy gene ATG5 revealed that ACER2-induced autophagy facilitates its effect on apoptosis. PMID: 28294157
    2. Results suggest that the ACER2/sphingosine pathway mediates programmed cell death in response to DNA damage through ROS production. PMID: 26943039
    3. c-Src-mediated signal positively regulates ACER activity in a Ca2+-independent manner. PMID: 24708996
    4. Results suggest that up-regulation of the ACER2/DHS pathway mediates the cytotoxicity of 4-HPR in tumor cells and that up-regulating or activating ACER2 may improve the anti-cancer activity of 4-HRR and other DHC-inducing agents. PMID: 20628055
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    6. ACER2 has broad substrate specificity and requires Ca(2+) for its activity; ACER2 has the cytosolic C terminus and luminal N terminus, which are essential for its activity, correct cellular localization, and regulation for protein glycosylation PMID: 20089856
    7. ACER2/sphingosine pathway plays an important role in regulating beta1 maturation and cell adhesion mediated by beta1 integrins PMID: 18945876

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Alkaline ceramidase family
  • 組織特異性：
    Highly expressed in placenta.
  • 數據庫鏈接：

    HGNC: 23675

    OMIM: 613492

    KEGG: hsa:340485

    STRING: 9606.ENSP00000342609

    UniGene: Hs.41379



主站蜘蛛池模板： 国产精品三级国产电影| 国产萌白酱喷水视频在线播放 | 国产又黄又刺激又高潮的网站| 桃花综合久久久久久久久久网| 久久视频这里只有精品在线观看| 精品999日本久久久影院| 成人免费播放视频777777| 嫖妓大龄熟妇正在播放| 亚洲午夜精品久久久久久人妖| 无码毛片aaa在线| 97人人模人人爽人人少妇| 欧美人与动欧交视频| 98视频精品全部国产| 日本三级欧美三级人妇视频 | 97在线观看永久免费视频| 99re6在线视频精品免费下载| 色妞精品av一区二区三区| 精品国产av最大网站| 亚洲妇女自偷自偷图片| 国产精品99精品久久免费| 18精品久久久无码午夜福利| 在线 | 麻豆国产传媒61国产免费 视频在线+欧美十亚洲曰本 | 日韩精品成人av在线观看| 久久人妻av中文字幕| 无码av天堂一区二区三区| 国产精品性夜天天拍拍2021| 国产午睡沙发被弄醒完整版| 囯产精品一区二区三区线| 欧美成人片在线观看| 给我免费的视频在线观看| 精品香蕉久久久午夜福利| 婷婷五月综合国产激情| 免费极品av一视觉盛宴| 57pao成人国产永久免费视频| 国产未发育呦交视频| 国产日产欧产精品精品app| 久久久久久人妻精品一区| 免费看少妇作爱视频| 国模裸体无码xxxx视频| 日韩国产网曝欧美第一页| 妺妺窝人体色www在线观看|