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  4. Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

  • 中文名稱：
    Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring(ALDH3A1)
  • 貨號：
    CSB-YP001572HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring(ALDH3A1)
  • 貨號：
    CSB-EP001572HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring(ALDH3A1)
  • 貨號：
    CSB-EP001572HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring(ALDH3A1)
  • 貨號：
    CSB-BP001572HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Aldehyde dehydrogenase, dimeric NADP-preferring(ALDH3A1)
  • 貨號：
    CSB-MP001572HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ALDH3A1
  • Uniprot No.：
  • 別名：
    Acetaldehyde dehydrogenase 3; AHD 4; AHD C; AHD4; AHDC; AL3A1_HUMAN; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase 3 family member A1 ; Aldehyde dehydrogenase 3A1; Aldehyde dehydrogenase; Aldehyde dehydrogenase class 3; Aldehyde dehydrogenase dimeric NADP preferring; Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase family 3 subfamily A1; Aldehyde dehydrogenase family 3, subfamily A, member 1; Aldehyde dehydrogenase isozyme 3; Aldehyde dehydrogenase type III; ALDH 3; ALDH 3A1; ALDH III; ALDH, stomach type; ALDH3 A1; ALDH3; ALDH3A 1; Aldh3a1; ALDHIII; dimeric NADP-preferring; MGC10406; Stomach aldehyde dehydrogenase; Tumor associated aldehyde dehydrogenase tumor ALDH
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-453
  • 氨基酸序列
    SKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNSVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
  • 基因功能參考文獻：
    1. ALDH3A1 appears to play an essential role in protecting cellular proteins against aggregation under stress conditions PMID: 28526614
    2. ALDH3A1 confers a multi-modality resistance phenotype in MCF-7 cells PMID: 27276244
    3. Molecular docking analysis depicted that Sulforaphane fits into the active site of ALDH3A1, and facilitates the catalytic mechanism of the enzyme. PMID: 27997560
    4. ALDH-3A1 expression correlates well with gastric cancer dysplasia and grades, differentiation, lymph node metastasis and cancer stage. PMID: 27279633
    5. Down-regulation of ALDH3 activity in trophoblast stem cells initiates trophoblast differentiation during placental development. PMID: 26124079
    6. ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms PMID: 26751691
    7. Reported increased expression of ALDH3A1, PDIA3, and PRDX2 in pterygia using a proteomic approach. These proteins are presumed to have a protective role against oxidative stress-induced apoptosis. PMID: 25221425
    8. SiRNA-mediated suppression of ALDH3A1 blocked ALDH enzymatic activity and augmented cytotoxicity in CSE-exposed cells. PMID: 24316006
    9. While ALDH3A1 was not found in prostate glands, it was present in prostatic intraepithelial neoplasia, further increased in carcinomas, and upregulated in lymphatic metastases. ALDH3A1 increased in DU145-cell-derived lung metastasis vs. local xenografts. PMID: 24762960
    10. No correlation between ALDH3A1 expression and patient survival or tumour recurrence was observed.In conclusion, ALDH3A1 is a marker of activation of the Wnt/ss-catenin pathway in hepatocellular carcinoma PMID: 24276407
    11. ALDH3A1 provides exceptional protection from the adverse effects of pathophysiological concentrations of 4-HNE such as may occur during periods of oxidative stress PMID: 22406320
    12. through modulation of PPARgamma or ALDH3A1, it may be possible to reduce cell proliferation in tumor cells or stimulate cell proliferation in normal cells during tissue regeneration. PMID: 21251908
    13. the UV-induced inactivation of ALDH3A1 is a result of non-native aggregation and associated structural changes rather than specific damage to the active site Cys PMID: 21203538
    14. Antihypertensives, nonopioid analgesics and hormonal contraceptives significantly affect the salivary ALDH3A1 activity. PMID: 21229876
    15. These findings suggest that a high level of expression of ALDH3 in cancerous liver tissues resulted from the expression or activation of at least two nuclear proteins reacting to the ALDH3 promoter region. PMID: 9855707
    16. ADH3*1 allele associated with high ADH activity and acetyaldehyde-DNA adducts in lung; may be a risk factor for lung cancer PMID: 12367788
    17. ALDH3A1 is a regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage PMID: 12706498
    18. Enzyme activity and localization of ALDH3A1 in the cornea. PMID: 12943535
    19. ALDH3A1 may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle PMID: 15905174
    20. In most cases, ALDH3A1 activity in tumor and bordering tissues was higher than in a control group PMID: 18536178
    21. the mechanism of salivary ALDH3A1 inactivation must be related to free radical activity, presumably in the salivary gland, but it is not simply correlated with antioxidatn capacity of saliva PMID: 19894643

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 組織特異性：
    High levels in stomach, esophagus and lung; low level in the liver and kidney.
  • 數據庫鏈接：

    HGNC: 405

    OMIM: 100660

    KEGG: hsa:218

    STRING: 9606.ENSP00000225740

    UniGene: Hs.531682



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