在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Alcohol dehydrogenase [NADP (+)] (AKR1A1)

  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-YP001538HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-EP001538HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-EP001538HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-BP001538HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-MP001538HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AKR1A1
  • Uniprot No.:
  • 別名:
    AK1A1_HUMAN; Akr1a1; Alcohol dehydrogenase [NADP+]; Alcohol dehydrogenase; Aldehyde reductase; Aldo keto reductase family 1 member A1 (aldehyde reductase); Aldo-keto reductase family 1 member A1; ALDR1; ALR; ARM; DD3; MGC12529; MGC1380
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-325
  • 氨基酸序列
    AASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids.
  • 基因功能參考文獻:
    1. Data (including data from studies in knockout and transgenic mice) suggest that AKR1A1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. PMID: 29763686
    2. prostaglandin F synthase activity of human and bovine aldo-keto reductases PMID: 23747692
    3. AKR1A1 could be involved in the metabolism of 4-hydroxynonenal and play a role in the resistance to oxidative stress PMID: 23643085
    4. AKR1A1 has little effect on the production of gamma-hydroxybutyrate PMID: 21276435
    5. structure of Apo R268A human aldose reductase reveals hinges and latches that control the kinetic mechanism PMID: 15769597
    6. the binding site residues deviating between ALR1 and ALR2 influence ligand affinity in a complex interplay, presumably involving changes of dynamic properties and differences of the solvation/desolvation balance upon ligand binding PMID: 18495158

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Apical cell membrane.
  • 蛋白家族:
    Aldo/keto reductase family
  • 組織特異性:
    Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • 數據庫鏈接:

    HGNC: 380

    OMIM: 103830

    KEGG: hsa:10327

    STRING: 9606.ENSP00000312606

    UniGene: Hs.474584



主站蜘蛛池模板: 国产精品久久久久7777按摩| 天天弄天天模| 人与禽性视频77777| 国产成人无码免费视频麻豆| 把腿张开老子臊烂你多p视频| 热99re久久精品这里都是精品| 亚洲精品一区二区三区蜜臀| 亚洲香蕉aⅴ视频在线播放| 国产未成女一区二区| 国产三级精品三级| 无码日韩人妻精品久久| 麻豆精品人妻一区二区三区蜜桃| 欧美天天拍在线视频| 免费啪视频在线观看视频网页| 96国产xxxx免费视频| 九九热在线视频观看这里只有精品 | 日本极品少妇xxxx| 99尹人香蕉国产免费天天| 国产精品天干在线观看| 久久综合九色综合久99| 欧美日韩精品人妻狠狠躁免费视频| 欧亚精品一区三区免费| av无码人妻波多野结衣| 老熟女高潮喷水了| 自慰小少妇毛又多又黑流白浆| 日韩经典精品无码一区| 久久青青草免费线频观| 亚洲日韩乱码一区二区三区四区 | 亚洲 熟女 久久 国产| 97色偷偷色噜噜狠狠爱网站 | 香蕉欧美成人精品a∨在线观看| 亚洲国产成人精品无码区蜜柚| 国产欧美成人一区二区a片| 国产超碰人人爽人人做| 国产白嫩护士在线播放| 久久99精品国产99久久6男男 | 日韩人妻无码精品系列| 亚洲精品鲁一鲁一区二区三区| 日产一区日产2区| 久久精品国产亚洲欧美| 884aa四虎影成人精品|