在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Alcohol dehydrogenase [NADP (+)] (AKR1A1)

  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-YP001538HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-EP001538HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-EP001538HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-BP001538HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase [NADP(+)](AKR1A1)
  • 貨號:
    CSB-MP001538HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AKR1A1
  • Uniprot No.:
  • 別名:
    AK1A1_HUMAN; Akr1a1; Alcohol dehydrogenase [NADP+]; Alcohol dehydrogenase; Aldehyde reductase; Aldo keto reductase family 1 member A1 (aldehyde reductase); Aldo-keto reductase family 1 member A1; ALDR1; ALR; ARM; DD3; MGC12529; MGC1380
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-325
  • 氨基酸序列
    AASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids.
  • 基因功能參考文獻:
    1. Data (including data from studies in knockout and transgenic mice) suggest that AKR1A1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. PMID: 29763686
    2. prostaglandin F synthase activity of human and bovine aldo-keto reductases PMID: 23747692
    3. AKR1A1 could be involved in the metabolism of 4-hydroxynonenal and play a role in the resistance to oxidative stress PMID: 23643085
    4. AKR1A1 has little effect on the production of gamma-hydroxybutyrate PMID: 21276435
    5. structure of Apo R268A human aldose reductase reveals hinges and latches that control the kinetic mechanism PMID: 15769597
    6. the binding site residues deviating between ALR1 and ALR2 influence ligand affinity in a complex interplay, presumably involving changes of dynamic properties and differences of the solvation/desolvation balance upon ligand binding PMID: 18495158

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Apical cell membrane.
  • 蛋白家族:
    Aldo/keto reductase family
  • 組織特異性:
    Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • 數據庫鏈接:

    HGNC: 380

    OMIM: 103830

    KEGG: hsa:10327

    STRING: 9606.ENSP00000312606

    UniGene: Hs.474584



主站蜘蛛池模板: 亚洲中文字幕无码一区二区三区| 性xxxx欧美老妇胖老太性多毛| 久久国产中文娱乐网| 高清无码午夜福利视频| 中文字幕久久久久人妻中出| 国产日韩综合av在线观看一区| 亚洲蜜桃v妇女| 精品欧洲av无码一区二区三区 | 日日噜噜夜夜狠狠va视频v| 好大好湿好硬顶到了好爽视频| 亚洲制服有码在线丝袜| 精品国产午夜理论片不卡精品| 国产亚洲精品久久久久四川人| 波多野42部无码喷潮| 久久久久久国产精品mv| 亚洲愉拍二区一区三区| 5566先锋影音夜色资源站在线观看 | 国产av福利久久| 开心五月激情综合婷婷色| 国产福利一区二区三区在线观看| 免费观看潮喷到高潮中文字幕| 亚洲r成人av久久人人爽| 亚洲综合久久一区二区| 美女裸体十八禁免费网站| 欧美成 人影片 aⅴ免费观看| 狠狠色噜噜狠狠狠狠777米奇小说| 成熟老妇女视频| 亚洲日韩av片在线观看| 国产百合互慰吃奶互揉视频| 久久精品国产精品亚洲毛片 | 香草乱码一二三四区别| 最新高清无码专区| 凹凸国产熟女精品视频| 亚洲最大激情中文字幕| 亚洲高清毛片一区二区| 国产无遮挡a片又黄又爽| 午夜福利不卡在线视频| 亚洲精品久久久久中文字幕二区| 中文字幕无码人妻aaa片| 永久免费无码国产| 亚洲老熟女与小伙bbwtv|