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Recombinant Human Alcohol dehydrogenase 1C (ADH1C)

  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase 1C(ADH1C)
  • 貨號:
    CSB-YP001355HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase 1C(ADH1C)
  • 貨號:
    CSB-EP001355HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase 1C(ADH1C)
  • 貨號:
    CSB-BP001355HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Alcohol dehydrogenase 1C(ADH1C)
  • 貨號:
    CSB-MP001355HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ADH1C
  • Uniprot No.:
  • 別名:
    ADH gamma subunit; ADH1C; ADH1G_HUMAN; Adh3; Alcohol dehydrogenase 1C (class I) gamma polypeptide; Alcohol dehydrogenase 1C; Alcohol dehydrogenase 1C gamma polypeptide; Alcohol dehydrogenase 3 (class I) gamma polypeptide; Alcohol dehydrogenase 3; Alcohol dehydrogenase subunit gamma; Aldehyde reductase; Class I alcohol dehydrogenase; OTTHUMP00000220209
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 表達(dá)區(qū)域:
    1-375aa
  • 氨基酸序列
    MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. The influence of ADH3 genetic polymorphisms on the status of liver function showed significant difference according to GGT measurement, but the same cannot be said on the other two values measuring SGOT and SGPT. PMID: 28239076
    2. Expression of xylanase under the regulation of ADH3, AOX1 and GAP was compared.The highest enzyme production was obtained with AOX1 culture at shake-flask level.The PADH3 cultures were more productive than AOX1 and GAP at fermentor scale PMID: 26835836
    3. The ADH1C *1/*2 polymorphism is likely associated with pancreatitis risk. PMID: 26634490
    4. the combination of genotypes ADH2 * 2, CYP2E1 * 1 combined with genotype homozygous ALDH2 * 1 found in this study could be leading to the population to a potential risk to alcoholism. The role of ADH3 was not indicated. PMID: 26848198
    5. Thus these findings suggest that the three variants of ADH1C, MnSOD and GSTM1 can be used to identify individuals who are at high risk to develop ALD and may be helpful in proper management of Indian alcoholics PMID: 26937962
    6. Results show that mutation of this protein confers associated protection against alcohol dependence. However these associations were not completely independent PMID: 24735490
    7. Among the Inuit in Greenland, ADH1C SNPs play a role in shaping their alcohol drinking patterns. PMID: 25311581
    8. findings suggest that ADH1C*2 is associated with alcohol dependence in the Turkish population displaying a dominant inheritance model. ADH1C*2 allele may contribute to the variance in heritability of alcohol dependence. PMID: 25372623
    9. Young male East Indians with at least one ADH1C*2 allele feel less effects of alcohol, including nausea. PMID: 25208201
    10. a positive association between inactive ADH1C G allele and alcohol consumption regarding gastric cancer risk was found, opposite to that found in previous studies PMID: 25524923
    11. Decreased expression of ADH1C gene is associated with disease progression. PMID: 24599561
    12. Alcohol dehydrogenase (ADH)1B and ADH1C are jointly associated with alcohol use disorders, but not consumption. PMID: 23895337
    13. additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence PMID: 23516558
    14. ADH1C polymorphism is not associated with childhood acute leukemia and maternal caffeinated beverage consumption during pregnancy. PMID: 23404349
    15. study failed to find any link between the ADH1C genotype and the cardioprotective effects of alcohol PMID: 23321361
    16. did not observe association of ADH1C polymorphism with esophageal cancer PMID: 22930414
    17. The frequency of ALDH2*2 and ADH3*1 alleles in risk drinkers was lower than that in safe drinkers in a male Tibetan population. PMID: 22279680
    18. No associations between alcohol dependence and polymorphisms in ADH1C were found in Mexican and Native Americans PMID: 22931071
    19. Findings suggest that a significantly higher presence of ADH1C*2 allele is associated with alcohol dependence in a Turkish population. PMID: 22414625
    20. This meta-analysis suggests that ADH1C polymorphism may not be associated with breast cancer development in Caucasians. PMID: 22353233
    21. ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians. PMID: 22675424
    22. findings support that ADH1C Ile may lower the risk of alcohol dependence and alcohol abuse as well as alcohol-related cirrhosis in pooled populations, with the strongest and most consistent effects in Asians PMID: 22476623
    23. in a study of alcohol metabolic genotypes in drunk drivers, the rs698 ADH1C and rs671 ALDH2 polymorphisms were not associated with MCV PMID: 21917409
    24. No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected. PMID: 22325912
    25. This study shows differences in the distribution of the frequency of allele ADH1C*1 between the Basque Country and Moroccan populations, and a new allele not described to date. PMID: 21303386
    26. This study suggested that the ADH1C Sspl polymorphism could play a significant role in the etiology of oral cancer. PMID: 21705789
    27. The presence of ADH3 in normal lung development (A549 cell line), & the capacity to convert retinol to retinoic acid, indicates that fetal human lung has the ability to regulate the supply of vitamin A from the pseudoglandular stage. PMID: 21482329
    28. the ADH1C*2/*2 genotype was associated with a 42% increase in risk of colorectal cancer when compared with the ADH1C*1/*1 genotype. PMID: 21163612
    29. Polymorphisms in ADH1C is associated with pancreatic cancer. PMID: 19068087
    30. The increased risk of oral clefts was evident only in mothers or children who carried the ADH1C haplotype associated with reduced alcohol metabolism. PMID: 20810466
    31. These findings suggest that a lower presence of ADH1C*1 allele is associated with squamous cell carcinoma of the head and neck PMID: 20448861
    32. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day. PMID: 20350778
    33. Results suggest that the ADH1C allele modifies the carcinogenic dose response for alcohol in the upper aerodigestive tract, giving rise to a gene-environment interaction. PMID: 20437850
    34. ADH1C polymorphisms were not significantly associated with pancreatic cancer risk. PMID: 19812523
    35. Besides the identification of new genetic factors related to alcohol biodisposition relevant to whites, this study provides unambiguous identification of diplotypes related to variability in alcohol biodisposition. PMID: 20101753
    36. ADH1C gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
    37. Report associations between genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors. PMID: 19447389
    38. A new coding variant has been identified at codon 351 of ADH1C, an allele found in most Native American populations studied, with allele frequencies of the new ADH1C*351Thr allele as high as 26%. PMID: 12500098
    39. Results suggest that alcohol dehydrogenase 3 catalysed S-nitrosoglutathione reduction is of physiological relevance in the metabolism of NO in humans. PMID: 12631283
    40. There is no significant interaction between alcohol consumption and ADH3 genotype. PMID: 12658118
    41. adh3 gene is implicated in alcoholism incidence among African Americans PMID: 12713190
    42. gastric ADH3 may highly effectively contribute to the first-pass metabolism at 0.5-3 M ethanol, an attainable range in the gastric lumen during alcohol consumption PMID: 12782305
    43. mutations in genes encoding ADH1C (G78Stop) as genetic risk factors for Parkinson disease . PMID: 15642852
    44. ADH1C polymorphisms in the cis-acting elements affect transcription. PMID: 15643610
    45. a slower alcohol clearance rate is associated with the ADH3 y2 allele [letter] PMID: 15842377
    46. mean corpuscular volume values were not associated with genotype polymorphisms of ADH1C PMID: 15897724
    47. No association has been revealed for the alcohol metabolism-related ADH3 genotype and Korean patients with alcoholism compared to Korean control subjects without alcoholism. PMID: 15902904
    48. Conversely, in both genders, no differences were found between ADH3 genotypes regarding all cardiovascular risk factors studied and carotid intima-media thickness. PMID: 15941567
    49. ADH1C genotype modifies the association between alcohol consumption and HDL levels among men and postmenopausal women not using postmenopausal hormones who drink moderately PMID: 16051248
    50. Alcohol dehydrogenase 3 null genotypes did not modify the risk of HCC due to alcohol intake. PMID: 16132793

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  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Zinc-containing alcohol dehydrogenase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 251

    OMIM: 103730

    KEGG: hsa:126

    UniGene: Hs.654537



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